hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04909
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SRSF10 | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | UniProt NCBI |
| SRRM2 | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | UniProt NCBI |
| TRA2B | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | UniProt NCBI |
| SRSF7 | Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7) | UniProt NCBI |
| TRA2A | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 1.31062068202e-06 | 0.8 | SRSF7 SRSF10 TRA2A TRA2B | Spliceosome |
| REAC:R-HSA-72163 | 1.46281017899e-05 | 0.8 | SRSF7 SRSF10 SRRM2 TRA2B | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.74585874891e-05 | 0.8 | SRSF7 SRSF10 SRRM2 TRA2B | mRNA Splicing |
| REAC:R-HSA-72203 | 4.46711337611e-05 | 0.8 | SRSF7 SRSF10 SRRM2 TRA2B | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:1261 | 6.7059790554e-05 | 0.4 | TRA2B SRRM2 | SRm160/300 complex |
| GO:0000377 | 0.000195429782732 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000195429782732 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000205071070663 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | RNA splicing, via transesterification reactions |
| WP:WP411 | 0.000211141596217 | 0.6 | SRSF7 SRSF10 TRA2B | mRNA Processing |
| GO:0048024 | 0.000234344694802 | 0.8 | SRSF7 SRSF10 TRA2A TRA2B | regulation of mRNA splicing, via spliceosome |
| GO:0008380 | 0.000460710313953 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | RNA splicing |
| CORUM:351 | 0.000596572408668 | 0.6 | TRA2B SRRM2 SRSF7 | Spliceosome |
| GO:0006397 | 0.00066476318296 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | mRNA processing |
| HPA:021010_03 | 0.00085259574109 | 0.8 | SRSF10 SRRM2 TRA2A TRA2B | heart muscle; myocytes[Uncertain,High] |
| GO:0043484 | 0.000995750426332 | 0.8 | SRSF7 SRSF10 TRA2A TRA2B | regulation of RNA splicing |
| GO:0050684 | 0.00102973750092 | 0.8 | SRSF7 SRSF10 TRA2A TRA2B | regulation of mRNA processing |
| REAC:R-HSA-8953854 | 0.00262978456954 | 0.8 | SRSF7 SRSF10 SRRM2 TRA2B | Metabolism of RNA |
| HPA:013010_03 | 0.00495058343732 | 0.6 | SRSF10 SRRM2 TRA2B | endometrium 1; cells in endometrial stroma[Uncertain,High] |
| HPA:032010_03 | 0.0057419029171 | 0.8 | SRSF10 SRRM2 TRA2A TRA2B | pancreas; exocrine glandular cells[Uncertain,High] |
| HPA:046010_03 | 0.0113397278716 | 0.6 | TRA2B TRA2A SRRM2 | smooth muscle; smooth muscle cells[Uncertain,High] |
| GO:0016071 | 0.0124036237668 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | mRNA metabolic process |
| GO:0006396 | 0.0184779947673 | 1.0 | SRSF7 SRSF10 SRRM2 TRA2A TRA2B | RNA processing |
| HPA:008020_03 | 0.0197707775352 | 0.6 | SRSF10 SRRM2 TRA2B | cerebral cortex; glial cells[Uncertain,High] |
| HPA:007020_03 | 0.0254943343705 | 0.6 | SRSF10 SRRM2 TRA2B | cerebellum; cells in granular layer[Uncertain,High] |
| HPA:043030_03 | 0.0268762439476 | 0.6 | SRSF10 SRRM2 TRA2B | skin 1; keratinocytes[Uncertain,High] |
| HPA:041010_03 | 0.0285148157715 | 0.6 | SRSF10 SRRM2 TRA2B | skeletal muscle; myocytes[Uncertain,High] |
| GO:0000381 | 0.0293579111372 | 0.6 | SRSF7 SRSF10 TRA2B | regulation of alternative mRNA splicing, via spliceosome |
| HPA:043040_03 | 0.0293581469203 | 0.6 | SRSF10 SRRM2 TRA2B | skin 1; melanocytes[Uncertain,High] |
| GO:1903311 | 0.0327910140884 | 0.8 | SRSF7 SRSF10 TRA2A TRA2B | regulation of mRNA metabolic process |
| HPA:046010_02 | 0.0381079541693 | 0.8 | SRSF10 SRRM2 TRA2A TRA2B | smooth muscle; smooth muscle cells[Uncertain,Medium] |
| HPA:006020_03 | 0.0384529972986 | 0.6 | SRSF10 SRRM2 TRA2B | caudate; neuronal cells[Uncertain,High] |
| HPA:007030_03 | 0.0384529972986 | 0.6 | SRSF10 SRRM2 TRA2B | cerebellum; cells in molecular layer[Uncertain,High] |
| HPA:009020_03 | 0.0397374089383 | 0.6 | SRSF10 SRRM2 TRA2B | cervix, uterine; squamous epithelial cells[Uncertain,High] |
| GO:0000380 | 0.0432266328844 | 0.6 | SRSF7 SRSF10 TRA2B | alternative mRNA splicing, via spliceosome |
| CORUM:2833 | 0.0499494897235 | 0.2 | SRRM2 | SRm160-SRm300 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TRA2B | SRSF7 | 1.0 | 0.949 | bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| TRA2B | TRA2A | 0.999 | 0.949 | bioplex (TRA2A) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SRRM2 | SRSF7 | 0.992 | 0.912 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SRRM2 | TRA2B | 0.988 | 0.901 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| TRA2B | SRSF10 | 0.777 | 0.752 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SRSF7 | TRA2A | 0.72 | 0.732 | bioplex (TRA2A) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SRSF7 | SRSF10 | 0.618 | 0.674 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| TRA2A | SRSF10 | 0.484 | 0.614 | bioplex (TRA2A) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SRRM2 | TRA2A | 0.05 | 0.296 | bioplex (TRA2A) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SRRM2 | SRSF10 | 0.013 | 0.147 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_04909 has an average edge precision of 0.693 which is ranked 1406 out of all 6965 complexes.
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