hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04946
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein) | UniProt NCBI |
| RGS14 | Regulator of G-protein signaling 14 (RGS14) | UniProt NCBI |
| RGS12 | Regulator of G-protein signaling 12 (RGS12) | UniProt NCBI |
| GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418594 | 1.71348623322e-05 | 1.0 | RGS14 GNAT3 GNAI1 RGS12 | G alpha (i) signalling events |
| REAC:R-HSA-388396 | 0.000313056285005 | 1.0 | RGS14 GNAT3 GNAI1 RGS12 | GPCR downstream signalling |
| REAC:R-HSA-372790 | 0.000435038620452 | 1.0 | RGS14 GNAT3 GNAI1 RGS12 | Signaling by GPCR |
| REAC:R-HSA-170670 | 0.000914071346391 | 0.5 | GNAI1 GNAT3 | Adenylate cyclase inhibitory pathway |
| REAC:R-HSA-392170 | 0.0019074750117 | 0.5 | GNAI1 GNAT3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-202040 | 0.00326103241616 | 0.5 | GNAI1 GNAT3 | G-protein activation |
| GO:0003924 | 0.00363242675247 | 1.0 | RGS14 GNAT3 GNAI1 RGS12 | GTPase activity |
| REAC:R-HSA-392518 | 0.00407268683926 | 0.5 | GNAI1 GNAT3 | Signal amplification |
| REAC:R-HSA-991365 | 0.00497416142364 | 0.5 | GNAI1 GNAT3 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 0.00497416142364 | 0.5 | GNAI1 GNAT3 | GABA B receptor activation |
| REAC:R-HSA-6814122 | 0.00742649434549 | 0.5 | GNAI1 GNAT3 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-418597 | 0.00947680746611 | 0.5 | GNAI1 GNAT3 | G alpha (z) signalling events |
| REAC:R-HSA-977443 | 0.0103665290697 | 0.5 | GNAI1 GNAT3 | GABA receptor activation |
| WP:WP536 | 0.0118694610121 | 0.5 | RGS14 GNAI1 | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-112043 | 0.012764635731 | 0.5 | GNAI1 GNAT3 | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.013274030298 | 0.5 | GNAI1 GNAT3 | G-protein mediated events |
| REAC:R-HSA-9009391 | 0.0214457367555 | 0.5 | GNAI1 GNAT3 | Extra-nuclear estrogen signaling |
| KEGG:04015 | 0.0293559966201 | 0.5 | RGS14 GNAI1 | Rap1 signaling pathway |
| REAC:R-HSA-111885 | 0.0364771667023 | 0.5 | GNAI1 GNAT3 | Opioid Signalling |
| REAC:R-HSA-390466 | 0.0399558314157 | 0.5 | GNAI1 GNAT3 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 0.0454682616856 | 0.5 | GNAI1 GNAT3 | Protein folding |
| CORUM:7086 | 0.0499140284799 | 0.25 | GNAI1 | GNAI1-GNB1-GNG12 complex |
| CORUM:6209 | 0.0499140284799 | 0.25 | GNAI1 | MT1-G(i)-RGS20 complex |
| CORUM:7014 | 0.0499140284799 | 0.25 | GNAI1 | GNAI1-GNGT1-GNB1 complex |
| CORUM:7015 | 0.0499140284799 | 0.25 | GNAI1 | GNAI1-GNB2-GNGT1 complex |
| CORUM:7016 | 0.0499140284799 | 0.25 | GNAI1 | GNAI1-GNB3-GNGT1 complex |
| CORUM:7017 | 0.0499140284799 | 0.25 | GNAI1 | GNAI1-GNB4-GNGT1 complex |
| CORUM:7018 | 0.0499140284799 | 0.25 | GNAI1 | GNAI1-GNB5-GNGT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAI1 | RGS12 | 0.994 | 0.919 | bioplex (GNAI1) bioplex_WMM |
| GNAI1 | RGS14 | 0.956 | 0.862 | bioplex (GNAI1) bioplex_WMM |
| GNAI1 | GNAT3 | 0.593 | 0.665 | bioplex (GNAI1) bioplex_WMM |
| RGS14 | RGS12 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| RGS14 | GNAT3 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| RGS12 | GNAT3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04946 has an average edge precision of 0.465 which is ranked 2765 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNAI1 | HuMAP2_00508 HuMAP2_01804 HuMAP2_04946 HuMAP2_05902 |
| RGS14 | HuMAP2_00508 HuMAP2_04946 HuMAP2_05902 |
| RGS12 | HuMAP2_00508 HuMAP2_01804 HuMAP2_03251 HuMAP2_03298 HuMAP2_03506 HuMAP2_04946 HuMAP2_05902 |
| GNAT3 | HuMAP2_00508 HuMAP2_04626 HuMAP2_04946 HuMAP2_05570 |