hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04952
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GSR | Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) | UniProt NCBI |
| PSAP | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] | UniProt NCBI |
| ECI1 | Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) | UniProt NCBI |
| ISCU | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein) | UniProt NCBI |
| HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003819 | 0.011725460578 | 0.4 | HMGCL PSAP | Death in childhood |
| WP:WP3925 | 0.0126363339816 | 0.4 | GSR HMGCL | Amino Acid metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSR | HMGCL | 0.075 | 0.357 | bioplex_WMM fraction |
| GSR | ISCU | 0.07 | 0.349 | bioplex_WMM fraction |
| GSR | PSAP | 0.054 | 0.299 | bioplex_WMM fraction |
| GSR | ECI1 | 0.042 | 0.27 | bioplex_WMM fraction |
| ECI1 | PSAP | 0.008 | 0.044 | bioplex_WMM WMM_only |
| PSAP | HMGCL | 0.005 | 0.012 | fraction |
| ECI1 | HMGCL | 0.0 | 0.009 | fraction |
Images
Click to enlarge
Complex HuMAP2_04952 has an average edge precision of 0.191 which is ranked 6290 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GSR | HuMAP2_00363 HuMAP2_01741 HuMAP2_02667 HuMAP2_04952 HuMAP2_06138 |
| PSAP | HuMAP2_00363 HuMAP2_00814 HuMAP2_04952 HuMAP2_06552 |
| ECI1 | HuMAP2_00363 HuMAP2_00952 HuMAP2_04952 HuMAP2_05948 |
| ISCU | HuMAP2_00363 HuMAP2_03941 HuMAP2_04952 HuMAP2_06543 |
| HMGCL | HuMAP2_01321 HuMAP2_01746 HuMAP2_04952 |