hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04962
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IMMT | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | UniProt NCBI |
| CHCHD6 | MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | UniProt NCBI |
| CHCHD3 | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | UniProt NCBI |
| CD244 | Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) | UniProt NCBI |
| CARD19 | Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) | UniProt NCBI |
| MTX3 | Metaxin-3 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 1.06951346208e-13 | 0.625 | CHCHD3 IMMT SAMM50 CHCHD6 MTX2 | MIB complex |
| REAC:R-HSA-8949613 | 2.30852101102e-10 | 0.625 | CHCHD3 IMMT SAMM50 CHCHD6 MTX2 | Cristae formation |
| REAC:R-HSA-1592230 | 6.28457933562e-08 | 0.625 | CHCHD3 IMMT SAMM50 CHCHD6 MTX2 | Mitochondrial biogenesis |
| CORUM:6255 | 9.41110885571e-08 | 0.375 | CHCHD3 IMMT CHCHD6 | MICOS complex |
| REAC:R-HSA-1852241 | 2.11050693283e-05 | 0.625 | CHCHD3 IMMT SAMM50 CHCHD6 MTX2 | Organelle biogenesis and maintenance |
| CORUM:6132 | 3.50546248845e-05 | 0.25 | IMMT CHCHD3 | MINOS complex |
| GO:0042407 | 4.65382761126e-05 | 0.5 | CHCHD3 IMMT SAMM50 CHCHD6 | cristae formation |
| GO:0061617 | 0.000177825159425 | 0.375 | CHCHD3 IMMT CHCHD6 | MICOS complex |
| GO:0007007 | 0.000189585536071 | 0.5 | CHCHD3 IMMT SAMM50 CHCHD6 | inner mitochondrial membrane organization |
| REAC:R-HSA-1268020 | 0.000608348414674 | 0.375 | MTX2 SAMM50 CHCHD3 | Mitochondrial protein import |
| REAC:R-HSA-9609507 | 0.00883818351303 | 0.375 | MTX2 SAMM50 CHCHD3 | Protein localization |
| GO:0007006 | 0.00928778966369 | 0.5 | CHCHD3 IMMT SAMM50 CHCHD6 | mitochondrial membrane organization |
| GO:0031305 | 0.0301968453576 | 0.375 | CHCHD3 IMMT CHCHD6 | integral component of mitochondrial inner membrane |
| GO:0031304 | 0.0330194726961 | 0.375 | CHCHD3 IMMT CHCHD6 | intrinsic component of mitochondrial inner membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MTX2 | IMMT | 1.0 | 0.949 | hein_WMM bioplex (MTX2) bioplex_WMM Guru boldt hein (MTX2) fraction boldt_WMM |
| MTX2 | SAMM50 | 1.0 | 0.949 | hein_WMM bioplex (MTX2) bioplex_WMM boldt youn_WMM hein (MTX2) boldt_WMM |
| MTX2 | CHCHD6 | 1.0 | 0.949 | hein_WMM bioplex (MTX2) bioplex_WMM boldt hein (MTX2) boldt_WMM |
| MTX2 | CHCHD3 | 0.997 | 0.93 | hein_WMM bioplex (MTX2) bioplex_WMM boldt hein (MTX2) boldt_WMM |
| MTX2 | MTX3 | 0.996 | 0.926 | hein_WMM bioplex (MTX2) bioplex_WMM hein (MTX2) |
| CARD19 | MTX2 | 0.972 | 0.885 | hein_WMM bioplex (MTX2) bioplex_WMM hein (MTX2) |
| SAMM50 | CHCHD3 | 0.73 | 0.735 | hein_WMM bioplex_WMM boldt hein (SAMM50) boldt_WMM |
| CARD19 | CD244 | 0.319 | 0.511 | bioplex (CD244) bioplex_WMM |
| IMMT | CD244 | 0.124 | 0.395 | bioplex (CD244) bioplex_WMM |
| IMMT | CHCHD3 | 0.064 | 0.349 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MTX2 | CD244 | 0.052 | 0.301 | bioplex (CD244) bioplex_WMM |
| IMMT | CHCHD6 | 0.04 | 0.269 | hein_WMM bioplex_WMM boldt boldt_WMM |
| SAMM50 | CHCHD6 | 0.031 | 0.238 | hein_WMM bioplex_WMM boldt boldt_WMM |
| IMMT | SAMM50 | 0.022 | 0.199 | hein_WMM bioplex_WMM boldt boldt_WMM |
| CHCHD6 | CHCHD3 | 0.021 | 0.192 | hein_WMM bioplex_WMM boldt boldt_WMM |
| CARD19 | CHCHD3 | 0.01 | 0.139 | hein_WMM bioplex_WMM WMM_only |
| CARD19 | IMMT | 0.01 | 0.139 | hein_WMM bioplex_WMM WMM_only |
| CARD19 | SAMM50 | 0.01 | 0.126 | hein_WMM bioplex_WMM WMM_only |
| CARD19 | MTX3 | 0.01 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | SAMM50 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| CARD19 | CHCHD6 | 0.009 | 0.114 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | IMMT | 0.009 | 0.111 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | CHCHD6 | 0.009 | 0.095 | hein_WMM bioplex_WMM WMM_only |
| MTX3 | CHCHD3 | 0.008 | 0.06 | hein_WMM bioplex_WMM WMM_only |
| SAMM50 | CD244 | 0.005 | 0.01 | bioplex (CD244) bioplex_WMM |
| CD244 | CHCHD3 | 0.004 | 0.015 | bioplex (CD244) bioplex_WMM |
| CD244 | CHCHD6 | 0.003 | 0.013 | bioplex (CD244) bioplex_WMM |
| MTX3 | CD244 | 0.0 | 0.008 | bioplex (CD244) bioplex_WMM |
Images
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Complex HuMAP2_04962 has an average edge precision of 0.35 which is ranked 3950 out of all 6965 complexes.
Related Complexes