hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04974
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TLR1 | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) | UniProt NCBI |
| TLR6 | Toll-like receptor 6 (CD antigen CD286) | UniProt NCBI |
| IQUB | IQ and ubiquitin-like domain-containing protein | UniProt NCBI |
| ALDH16A1 | Aldehyde dehydrogenase family 16 member A1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3877 | 0.000176203894069 | 0.5 | TLR1 TLR6 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| REAC:R-HSA-5602498 | 0.000361772624521 | 0.5 | TLR1 TLR6 | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5603041 | 0.000452175281072 | 0.5 | TLR1 TLR6 | IRAK4 deficiency (TLR2/4) |
| WP:WP3858 | 0.000633595541779 | 0.5 | TLR1 TLR6 | Toll-like Receptor Signaling |
| REAC:R-HSA-5686938 | 0.00136571756437 | 0.5 | TLR1 TLR6 | Regulation of TLR by endogenous ligand |
| REAC:R-HSA-5602358 | 0.00253927088831 | 0.5 | TLR1 TLR6 | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.00253927088831 | 0.5 | TLR1 TLR6 | Diseases of Immune System |
| WP:WP75 | 0.0063819591539 | 0.5 | TLR1 TLR6 | Toll-like Receptor Signaling Pathway |
| KEGG:04620 | 0.00726841321698 | 0.5 | TLR1 TLR6 | Toll-like receptor signaling pathway |
| GO:0035663 | 0.00811409485621 | 0.5 | TLR1 TLR6 | Toll-like receptor 2 binding |
| GO:0070340 | 0.00811409485621 | 0.5 | TLR1 TLR6 | detection of bacterial lipopeptide |
| WP:WP1449 | 0.0114775392713 | 0.5 | TLR1 TLR6 | Regulation of toll-like receptor signaling pathway |
| GO:0042494 | 0.0162267366884 | 0.5 | TLR1 TLR6 | detection of bacterial lipoprotein |
| KEGG:05152 | 0.0220952935316 | 0.5 | TLR1 TLR6 | Tuberculosis |
| REAC:R-HSA-1236974 | 0.0331557329305 | 0.5 | TLR1 TLR6 | ER-Phagosome pathway |
| REAC:R-HSA-168188 | 0.0390714342086 | 0.5 | TLR1 TLR6 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.0390714342086 | 0.5 | TLR1 TLR6 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| GO:0070339 | 0.0405595771497 | 0.5 | TLR1 TLR6 | response to bacterial lipopeptide |
| GO:0071221 | 0.0405595771497 | 0.5 | TLR1 TLR6 | cellular response to bacterial lipopeptide |
| GO:0071220 | 0.0405595771497 | 0.5 | TLR1 TLR6 | cellular response to bacterial lipoprotein |
| REAC:R-HSA-168179 | 0.041754071825 | 0.5 | TLR1 TLR6 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.041754071825 | 0.5 | TLR1 TLR6 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-1236975 | 0.0435915557177 | 0.5 | TLR1 TLR6 | Antigen processing-Cross presentation |
| CORUM:7048 | 0.0499140284799 | 0.25 | TLR1 | TLR1-TLR2 complex |
| CORUM:7049 | 0.0499140284799 | 0.25 | TLR1 | TLR1-TLR2-lipoprotein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TLR1 | TLR6 | 0.977 | 0.893 | bioplex (TLR1) bioplex_WMM |
| TLR6 | IQUB | 0.058 | 0.325 | bioplex (IQUB) bioplex_WMM |
| TLR1 | ALDH16A1 | 0.024 | 0.214 | bioplex (TLR1) bioplex_WMM |
| TLR6 | ALDH16A1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04974 has an average edge precision of 0.36 which is ranked 3762 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TLR1 | HuMAP2_00141 HuMAP2_02098 HuMAP2_04974 |
| TLR6 | HuMAP2_00141 HuMAP2_02098 HuMAP2_04974 |
| IQUB | HuMAP2_02098 HuMAP2_04974 |
| ALDH16A1 | HuMAP2_02436 HuMAP2_03576 HuMAP2_04974 HuMAP2_06858 |