hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04988
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | UniProt NCBI |
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | UniProt NCBI |
| RPS6KA5 | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | UniProt NCBI |
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | UniProt NCBI |
| MAPKAPK2 | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2637 | 1.15711528028e-11 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | Structural Pathway of Interleukin 1 (IL-1) |
| WP:WP400 | 3.69152214444e-09 | 0.8 | MAPKAPK2 MKNK1 MAPK14 RPS6KA5 | p38 MAPK Signaling Pathway |
| WP:WP382 | 2.43289665485e-08 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | MAPK Signaling Pathway |
| KEGG:04010 | 6.87306579932e-08 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | MAPK signaling pathway |
| REAC:R-HSA-198725 | 6.24012216224e-06 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Nuclear Events (kinase and transcription factor activation) |
| WP:WP3888 | 8.32729603862e-06 | 0.8 | MAPKAPK2 MKNK1 MAPK14 RPS6KA5 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-450282 | 1.21879917622e-05 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | MAPK targets/ Nuclear events mediated by MAP kinases |
| GO:0009931 | 3.17736949706e-05 | 0.6 | MAPKAPK2 MKNK2 MKNK1 | calcium-dependent protein serine/threonine kinase activity |
| GO:0010857 | 3.17736949706e-05 | 0.6 | MAPKAPK2 MKNK2 MKNK1 | calcium-dependent protein kinase activity |
| GO:0018105 | 4.11426271691e-05 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | peptidyl-serine phosphorylation |
| GO:0018209 | 5.9036082881e-05 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | peptidyl-serine modification |
| REAC:R-HSA-450294 | 0.000107327354708 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.000141520021869 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Interleukin-17 signaling |
| REAC:R-HSA-187037 | 0.000167928044622 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Signaling by NTRK1 (TRKA) |
| KEGG:04722 | 0.000169883843985 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Neurotrophin signaling pathway |
| REAC:R-HSA-975871 | 0.000238892911782 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.000238892911782 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.000238892911782 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.00025697910325 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.000266353842167 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.000266353842167 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-199920 | 0.000283261545489 | 0.4 | MAPKAPK2 RPS6KA5 | CREB phosphorylation |
| REAC:R-HSA-168188 | 0.000306125075711 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 0.000306125075711 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 0.000306125075711 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 0.000316649083447 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.000327410819085 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.000338412904811 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.000338412904811 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-166166 | 0.000349657961729 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.000349657961729 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | TRIF(TICAM1)-mediated TLR4 signaling |
| WP:WP734 | 0.000399978956636 | 0.4 | MAPKAPK2 RPS6KA5 | Serotonin Receptor 4/6/7 and NR3C Signaling |
| REAC:R-HSA-9006934 | 0.000402506828977 | 0.8 | MAPKAPK2 MKNK1 MAPK14 RPS6KA5 | Signaling by Receptor Tyrosine Kinases |
| GO:0004674 | 0.000442234784145 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | protein serine/threonine kinase activity |
| WP:WP3879 | 0.000509836133129 | 0.4 | MKNK1 MKNK2 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| REAC:R-HSA-166016 | 0.000717394603045 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-171007 | 0.000889652787086 | 0.4 | MAPKAPK2 MAPK14 | p38MAPK events |
| REAC:R-HSA-168898 | 0.00120028939708 | 0.6 | MAPKAPK2 MAPK14 RPS6KA5 | Toll-like Receptor Cascades |
| REAC:R-HSA-167044 | 0.00183199274719 | 0.4 | MAPKAPK2 MAPK14 | Signalling to RAS |
| GO:0004672 | 0.00204929477256 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | protein kinase activity |
| GO:0004683 | 0.00208420080219 | 0.6 | MAPKAPK2 MKNK2 MKNK1 | calmodulin-dependent protein kinase activity |
| REAC:R-HSA-198753 | 0.0031096034254 | 0.4 | RPS6KA5 MAPK14 | ERK/MAPK targets |
| REAC:R-HSA-450302 | 0.00340529843133 | 0.4 | MAPKAPK2 MAPK14 | activated TAK1 mediates p38 MAPK activation |
| WP:WP4566 | 0.00343593293187 | 0.4 | RPS6KA5 MAPK14 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP195 | 0.00422982513182 | 0.4 | MAPKAPK2 MAPK14 | IL-1 signaling pathway |
| WP:WP585 | 0.00474544100801 | 0.4 | RPS6KA5 MAPK14 | Interferon type I signaling pathways |
| GO:0016773 | 0.00479827601007 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | phosphotransferase activity, alcohol group as acceptor |
| REAC:R-HSA-187687 | 0.00546022370076 | 0.4 | MAPKAPK2 MAPK14 | Signalling to ERKs |
| KEGG:04370 | 0.00633066651578 | 0.4 | MAPKAPK2 MAPK14 | VEGF signaling pathway |
| GO:0016301 | 0.00732992354676 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | kinase activity |
| KEGG:04625 | 0.0162467151192 | 0.4 | MAPKAPK2 MAPK14 | C-type lectin receptor signaling pathway |
| KEGG:04668 | 0.018144370474 | 0.4 | RPS6KA5 MAPK14 | TNF signaling pathway |
| GO:0016772 | 0.0188407727751 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | transferase activity, transferring phosphorus-containing groups |
| KEGG:04066 | 0.020974746694 | 0.4 | MKNK1 MKNK2 | HIF-1 signaling pathway |
| WP:WP3915 | 0.0250517914711 | 0.4 | RPS6KA5 MAPK14 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP2380 | 0.0301079862712 | 0.4 | RPS6KA5 MAPK14 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| KEGG:04910 | 0.0327287628992 | 0.4 | MKNK1 MKNK2 | Insulin signaling pathway |
| GO:0018193 | 0.0346157101499 | 1.0 | MAPKAPK2 RPS6KA5 MKNK1 MKNK2 MAPK14 | peptidyl-amino acid modification |
| KEGG:04261 | 0.0348468299156 | 0.4 | RPS6KA5 MAPK14 | Adrenergic signaling in cardiomyocytes |
| WP:WP481 | 0.0385448371419 | 0.4 | RPS6KA5 MAPK14 | Insulin Signaling |
| WP:WP437 | 0.0415833403121 | 0.4 | RPS6KA5 MAPK14 | EGF/EGFR Signaling Pathway |
| KEGG:04218 | 0.0439700127241 | 0.4 | MAPKAPK2 MAPK14 | Cellular senescence |
| REAC:R-HSA-450531 | 0.0465369402216 | 0.4 | MAPKAPK2 MAPK14 | Regulation of mRNA stability by proteins that bind AU-rich elements |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPKAPK2 | MAPK14 | 1.0 | 0.949 | hein_WMM bioplex (MAPK14) bioplex_WMM hein (MAPK14) |
| MAPK14 | MKNK1 | 0.991 | 0.91 | bioplex (MAPK14) bioplex_WMM |
| MKNK2 | MAPK14 | 0.99 | 0.909 | bioplex (MAPK14) bioplex_WMM |
| MAPK14 | RPS6KA5 | 0.965 | 0.874 | bioplex (MAPK14) bioplex_WMM |
| MKNK2 | MKNK1 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| MAPKAPK2 | MKNK1 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| MAPKAPK2 | MKNK2 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| RPS6KA5 | MKNK1 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| MAPKAPK2 | RPS6KA5 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| MKNK2 | RPS6KA5 | 0.009 | 0.104 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04988 has an average edge precision of 0.427 which is ranked 3054 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK14 | HuMAP2_01116 HuMAP2_01822 HuMAP2_04988 |
| MKNK2 | HuMAP2_01116 HuMAP2_04988 |
| RPS6KA5 | HuMAP2_01116 HuMAP2_04988 |
| MKNK1 | HuMAP2_01116 HuMAP2_04988 HuMAP2_05648 |
| MAPKAPK2 | HuMAP2_00140 HuMAP2_04988 HuMAP2_05232 HuMAP2_05959 HuMAP2_06862 |