hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04993
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WARS | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | UniProt NCBI |
| EZR | Ezrin (Cytovillin) (Villin-2) (p81) | UniProt NCBI |
| MSN | Moesin (Membrane-organizing extension spike protein) | UniProt NCBI |
| RDX | Radixin | UniProt NCBI |
| ACAA2 | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-) (EC 3.1.2.1) (EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1905668 | 1.81582264982e-05 | 0.6 | RDX MSN EZR | positive regulation of protein localization to endosome |
| GO:1902966 | 1.81582264982e-05 | 0.6 | RDX MSN EZR | positive regulation of protein localization to early endosome |
| GO:1902965 | 1.81582264982e-05 | 0.6 | RDX MSN EZR | regulation of protein localization to early endosome |
| GO:1905666 | 3.17736949706e-05 | 0.6 | RDX MSN EZR | regulation of protein localization to endosome |
| REAC:R-HSA-437239 | 3.84212387398e-05 | 0.6 | RDX MSN EZR | Recycling pathway of L1 |
| GO:2000643 | 5.0832789986e-05 | 0.6 | RDX MSN EZR | positive regulation of early endosome to late endosome transport |
| GO:1902946 | 7.62415024416e-05 | 0.6 | RDX MSN EZR | protein localization to early endosome |
| GO:1903651 | 0.000199619769136 | 0.6 | RDX MSN EZR | positive regulation of cytoplasmic transport |
| WP:WP51 | 0.00024878117453 | 0.6 | RDX MSN EZR | Regulation of Actin Cytoskeleton |
| KEGG:04530 | 0.000424294655338 | 0.6 | RDX MSN EZR | Tight junction |
| REAC:R-HSA-373760 | 0.000596598643168 | 0.6 | RDX MSN EZR | L1CAM interactions |
| GO:2000641 | 0.000739960245213 | 0.6 | RDX MSN EZR | regulation of early endosome to late endosome transport |
| GO:0036010 | 0.000878614215261 | 0.6 | RDX MSN EZR | protein localization to endosome |
| KEGG:04810 | 0.000910491071115 | 0.6 | RDX MSN EZR | Regulation of actin cytoskeleton |
| KEGG:05205 | 0.000925161775741 | 0.6 | RDX MSN EZR | Proteoglycans in cancer |
| GO:1903649 | 0.00160515829483 | 0.6 | RDX MSN EZR | regulation of cytoplasmic transport |
| GO:0061028 | 0.00541762673764 | 0.6 | RDX MSN EZR | establishment of endothelial barrier |
| WP:WP2324 | 0.00688743357746 | 0.4 | EZR MSN | AGE/RAGE pathway |
| GO:0001885 | 0.00703245670927 | 0.6 | RDX MSN EZR | endothelial cell development |
| GO:0045022 | 0.00703245670927 | 0.6 | RDX MSN EZR | early endosome to late endosome transport |
| GO:0098927 | 0.00826983957236 | 0.6 | RDX MSN EZR | vesicle-mediated transport between endosomal compartments |
| GO:0005902 | 0.00826983957236 | 0.6 | RDX MSN EZR | microvillus |
| KEGG:04670 | 0.0162467151192 | 0.4 | EZR MSN | Leukocyte transendothelial migration |
| GO:0030175 | 0.0278679504637 | 0.6 | RDX MSN EZR | filopodium |
| GO:0045446 | 0.0432266328844 | 0.6 | RDX MSN EZR | endothelial cell differentiation |
| GO:0022614 | 0.0450641792523 | 0.4 | EZR MSN | membrane to membrane docking |
| MIRNA:hsa-miR-1251-3p | 0.0482780268961 | 0.4 | RDX WARS | hsa-miR-1251-3p |
| CORUM:6784 | 0.0499494897235 | 0.2 | EZR | SCHIP1-EZR-NHERF2 complex |
| CORUM:6791 | 0.0499494897235 | 0.2 | EZR | NHERF1-NPT2A-EZR complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EZR | RDX | 0.989 | 0.906 | hein_WMM bioplex_WMM youn_WMM hein (EZR) gupta_WMM treiber_WMM |
| MSN | EZR | 0.965 | 0.874 | hein_WMM bioplex_WMM hein (EZR,MSN) gupta_WMM treiber_WMM |
| MSN | RDX | 0.89 | 0.818 | hein_WMM bioplex_WMM hein (MSN) treiber_WMM |
| WARS | EZR | 0.852 | 0.791 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| EZR | ACAA2 | 0.748 | 0.742 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| ACAA2 | RDX | 0.744 | 0.74 | bioplex_WMM Guru gupta_WMM fraction |
| MSN | ACAA2 | 0.468 | 0.604 | bioplex_WMM Guru fraction |
| WARS | MSN | 0.009 | 0.093 | bioplex_WMM gupta_WMM fraction |
| WARS | RDX | 0.0 | 0.008 | bioplex_WMM youn_WMM gupta_WMM fraction |
| WARS | ACAA2 | 0.0 | 0.001 | bioplex_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_04993 has an average edge precision of 0.558 which is ranked 2148 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WARS | HuMAP2_01312 HuMAP2_01572 HuMAP2_04993 |
| EZR | HuMAP2_02855 HuMAP2_02912 HuMAP2_04993 HuMAP2_06912 |
| MSN | HuMAP2_02855 HuMAP2_02912 HuMAP2_04350 HuMAP2_04993 |
| RDX | HuMAP2_02855 HuMAP2_02912 HuMAP2_04993 HuMAP2_06912 |
| ACAA2 | HuMAP2_02855 HuMAP2_02912 HuMAP2_04993 HuMAP2_05019 HuMAP2_06912 |