hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04995
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPL3 | 60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B) (Large ribosomal subunit protein uL3) | UniProt NCBI |
| RPL4 | 60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4) | UniProt NCBI |
| RPL6 | 60S ribosomal protein L6 (Large ribosomal subunit protein eL6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) | UniProt NCBI |
| RPL10L | 60S ribosomal protein L10-like (Large ribosomal subunit protein uL16-like) | UniProt NCBI |
| RPL21 | 60S ribosomal protein L21 (Large ribosomal subunit protein eL21) | UniProt NCBI |
| RPL27 | 60S ribosomal protein L27 (Large ribosomal subunit protein eL27) | UniProt NCBI |
| RPS9 | 40S ribosomal protein S9 (Small ribosomal subunit protein uS4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156902 | 3.29550769899e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Peptide chain elongation |
| REAC:R-HSA-192823 | 3.29550769899e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Viral mRNA Translation |
| REAC:R-HSA-156842 | 4.5477220123e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Eukaryotic Translation Elongation |
| REAC:R-HSA-72764 | 4.5477220123e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Eukaryotic Translation Termination |
| REAC:R-HSA-2408557 | 4.5477220123e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Selenocysteine synthesis |
| REAC:R-HSA-975956 | 5.31357736321e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-72689 | 8.30974112849e-14 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Formation of a pool of free 40S subunits |
| REAC:R-HSA-156827 | 1.65191241802e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | L13a-mediated translational silencing of Ceruloplasmin expression |
| KEGG:03010 | 1.71871397454e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Ribosome |
| REAC:R-HSA-1799339 | 1.76309883077e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-72706 | 1.76309883077e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-927802 | 2.00483187801e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-975957 | 2.00483187801e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-2408522 | 2.13598910367e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Selenoamino acid metabolism |
| REAC:R-HSA-72613 | 2.73688666872e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 2.73688666872e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Cap-dependent Translation Initiation |
| REAC:R-HSA-168273 | 5.48378973816e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-168255 | 8.41074563742e-13 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Influenza Life Cycle |
| REAC:R-HSA-168254 | 1.38713452157e-12 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Influenza Infection |
| REAC:R-HSA-9010553 | 3.42764669136e-12 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-6791226 | 5.82880993523e-12 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Major pathway of rRNA processing in the nucleolus and cytosol |
| CORUM:306 | 6.80455022623e-12 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | Ribosome, cytoplasmic |
| REAC:R-HSA-8868773 | 8.54603562385e-12 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 1.22838081983e-11 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | rRNA processing |
| WP:WP477 | 1.23562694719e-11 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | Cytoplasmic Ribosomal Proteins |
| REAC:R-HSA-376176 | 1.85450914367e-11 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Signaling by ROBO receptors |
| GO:0022626 | 2.3106897156e-11 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | cytosolic ribosome |
| CORUM:3055 | 3.29197923534e-11 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | Nop56p-associated pre-rRNA complex |
| REAC:R-HSA-72766 | 1.65170033308e-10 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Translation |
| CORUM:308 | 2.49713257939e-10 | 0.714285714286 | RPL27 RPL21 RPL6 RPL4 RPL3 | 60S ribosomal subunit, cytoplasmic |
| GO:0003735 | 2.78755182964e-10 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | structural constituent of ribosome |
| GO:0022625 | 4.69206908828e-10 | 0.857142857143 | RPL4 RPL10L RPL21 RPL6 RPL3 RPL27 | cytosolic large ribosomal subunit |
| REAC:R-HSA-71291 | 6.11383480836e-10 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Metabolism of amino acids and derivatives |
| REAC:R-HSA-5663205 | 7.31782505462e-10 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Infectious disease |
| GO:0044391 | 1.61025758638e-09 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | ribosomal subunit |
| GO:0044445 | 3.67285865129e-09 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | cytosolic part |
| GO:0005840 | 3.80470485929e-09 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | ribosome |
| REAC:R-HSA-422475 | 9.24271697019e-09 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Axon guidance |
| GO:0006614 | 1.43180479835e-08 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | SRP-dependent cotranslational protein targeting to membrane |
| GO:0006613 | 2.13116011423e-08 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | cotranslational protein targeting to membrane |
| GO:0045047 | 3.48664239809e-08 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | protein targeting to ER |
| GO:0072599 | 4.39595027341e-08 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | establishment of protein localization to endoplasmic reticulum |
| GO:0015934 | 4.65175563472e-08 | 0.857142857143 | RPL4 RPL10L RPL21 RPL6 RPL3 RPL27 | large ribosomal subunit |
| REAC:R-HSA-8953854 | 4.99493959204e-08 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Metabolism of RNA |
| GO:0000184 | 5.80251295541e-08 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| GO:0070972 | 1.43380219169e-07 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | protein localization to endoplasmic reticulum |
| GO:0006612 | 5.64102731202e-07 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | protein targeting to membrane |
| REAC:R-HSA-1266738 | 5.65878705755e-07 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Developmental Biology |
| GO:0006413 | 6.53156188555e-07 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | translational initiation |
| REAC:R-HSA-1643685 | 6.9833363268e-07 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Disease |
| GO:0019083 | 7.27373814613e-07 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | viral transcription |
| GO:0019080 | 1.29364697618e-06 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | viral gene expression |
| GO:0000956 | 1.71811582868e-06 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | nuclear-transcribed mRNA catabolic process |
| GO:0005198 | 1.73023429856e-06 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | structural molecule activity |
| GO:0090150 | 1.1322463778e-05 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | establishment of protein localization to membrane |
| GO:1990904 | 4.11074957841e-05 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | ribonucleoprotein complex |
| GO:0006402 | 4.40985303784e-05 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | mRNA catabolic process |
| REAC:R-HSA-392499 | 6.45437442595e-05 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Metabolism of proteins |
| GO:0006605 | 6.56328466887e-05 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | protein targeting |
| GO:0006401 | 7.37008656254e-05 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | RNA catabolic process |
| REAC:R-HSA-1430728 | 8.36020973003e-05 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | Metabolism |
| GO:0016032 | 0.000204867252814 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | viral process |
| GO:0034655 | 0.000282870023661 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | nucleobase-containing compound catabolic process |
| GO:0072594 | 0.000334520650493 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | establishment of protein localization to organelle |
| GO:0044403 | 0.000365432693166 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | symbiotic process |
| GO:0046700 | 0.000439730292192 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | heterocycle catabolic process |
| GO:0044270 | 0.000445099387973 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | cellular nitrogen compound catabolic process |
| GO:0072657 | 0.000445099387973 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | protein localization to membrane |
| GO:0044419 | 0.000507848315266 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | interspecies interaction between organisms |
| GO:0019439 | 0.000513899865657 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | aromatic compound catabolic process |
| GO:0006412 | 0.000545064820292 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | translation |
| GO:1901361 | 0.000648142238205 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | organic cyclic compound catabolic process |
| GO:0043043 | 0.000709429414576 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | peptide biosynthetic process |
| CORUM:5266 | 0.000914055366538 | 0.285714285714 | RPL4 RPL6 | TNF-alpha/NF-kappa B signaling complex 6 |
| GO:0042254 | 0.000959205344393 | 0.714285714286 | RPL6 RPL3 RPS9 RPL10L RPL27 | ribosome biogenesis |
| GO:0043604 | 0.00209516746076 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | amide biosynthetic process |
| GO:0006518 | 0.00215454474769 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | peptide metabolic process |
| CORUM:5380 | 0.00300595539129 | 0.285714285714 | RPL21 RPL27 | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) |
| GO:0016071 | 0.00396065506267 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | mRNA metabolic process |
| GO:0051704 | 0.00488132284224 | 1.0 | RPS9 RPL10L RPL21 RPL6 RPL3 RPL27 RPL4 | multi-organism process |
| GO:0033365 | 0.00607930828463 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | protein localization to organelle |
| GO:0005925 | 0.00744714769738 | 0.714285714286 | RPL6 RPL3 RPS9 RPL4 RPL27 | focal adhesion |
| GO:0005924 | 0.00765938747267 | 0.714285714286 | RPL6 RPL3 RPS9 RPL4 RPL27 | cell-substrate adherens junction |
| GO:0030055 | 0.00821112400814 | 0.714285714286 | RPL6 RPL3 RPS9 RPL4 RPL27 | cell-substrate junction |
| GO:0000027 | 0.00822626332948 | 0.428571428571 | RPL3 RPL10L RPL6 | ribosomal large subunit assembly |
| GO:0022613 | 0.00928376179311 | 0.714285714286 | RPL6 RPL3 RPS9 RPL10L RPL27 | ribonucleoprotein complex biogenesis |
| GO:0043603 | 0.0101741576841 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | cellular amide metabolic process |
| MIRNA:hsa-miR-652-3p | 0.0104106386262 | 0.428571428571 | RPL21 RPL4 RPL27 | hsa-miR-652-3p |
| GO:0006886 | 0.0180209467821 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | intracellular protein transport |
| GO:0044265 | 0.024558499611 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | cellular macromolecule catabolic process |
| GO:0005912 | 0.0262720451942 | 0.714285714286 | RPL6 RPL3 RPS9 RPL4 RPL27 | adherens junction |
| GO:0070161 | 0.0295754593084 | 0.714285714286 | RPL6 RPL3 RPS9 RPL4 RPL27 | anchoring junction |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | RPS9 RPL21 RPL6 RPL3 RPL27 RPL4 | CORUM root |
| MIRNA:hsa-miR-16-5p | 0.0475131879423 | 0.714285714286 | RPL21 RPL6 RPL10L RPL4 RPL3 | hsa-miR-16-5p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPL4 | RPL6 | 1.0 | 0.949 | hein_WMM bioplex (RPL6) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL4 | RPL3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL21 | RPL3 | 1.0 | 0.949 | hein_WMM bioplex (RPL21) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL6 | RPL21 | 1.0 | 0.949 | hein_WMM bioplex (RPL21,RPL6) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPS9 | RPL27 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| RPL6 | RPS9 | 1.0 | 0.949 | hein_WMM bioplex (RPL6) bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| RPL4 | RPL21 | 1.0 | 0.949 | hein_WMM bioplex (RPL21) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL21 | RPL27 | 1.0 | 0.949 | hein_WMM bioplex (RPL21) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL4 | RPL27 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL3 | RPL27 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL6 | RPL27 | 1.0 | 0.949 | hein_WMM bioplex (RPL6) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL4 | RPS9 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| RPL3 | RPS9 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| RPL6 | RPL3 | 1.0 | 0.949 | hein_WMM bioplex (RPL6) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL21 | RPS9 | 1.0 | 0.949 | hein_WMM bioplex (RPL21) bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| RPL10L | RPS9 | 0.929 | 0.846 | fraction |
| RPL6 | RPL10L | 0.805 | 0.767 | gupta_WMM fraction |
| RPL10L | RPL21 | 0.798 | 0.764 | gupta_WMM fraction |
| RPL4 | RPL10L | 0.711 | 0.728 | gupta_WMM fraction |
| RPL10L | RPL3 | 0.437 | 0.582 | gupta_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_04995 has an average edge precision of 0.896 which is ranked 585 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPL3 | HuMAP2_02207 HuMAP2_04995 HuMAP2_05622 |
| RPL4 | HuMAP2_02207 HuMAP2_02743 HuMAP2_04995 HuMAP2_05622 |
| RPL6 | HuMAP2_01548 HuMAP2_04995 HuMAP2_06326 |
| RPL10L | HuMAP2_02207 HuMAP2_04995 |
| RPL21 | HuMAP2_02207 HuMAP2_04995 HuMAP2_05622 |
| RPL27 | HuMAP2_02207 HuMAP2_04995 HuMAP2_05249 |
| RPS9 | HuMAP2_02207 HuMAP2_04995 HuMAP2_05622 HuMAP2_05807 |