hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04999
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACACA | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] | UniProt NCBI |
| PRKG1 | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | UniProt NCBI |
| GIMAP8 | GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT) | UniProt NCBI |
| PTK2 | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | UniProt NCBI |
| OAS2 | 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3888 | 0.00113645450729 | 0.6 | PRKG1 ACACA PTK2 | VEGFA-VEGFR2 Signaling Pathway |
| WP:WP2034 | 0.00893290103597 | 0.4 | ACACA PTK2 | Leptin signaling pathway |
| WP:WP2355 | 0.0115135837289 | 0.4 | ACACA PTK2 | Corticotropin-releasing hormone signaling pathway |
| CORUM:5712 | 0.0499494897235 | 0.2 | PTK2 | FAK-beta5 integrin complex, VEGF induced |
| CORUM:7116 | 0.0499494897235 | 0.2 | PTK2 | GRB7-PTK2 complex |
| CORUM:7416 | 0.0499494897235 | 0.2 | PTK2 | GJB2-PTK2-NANOG complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OAS2 | ACACA | 0.189 | 0.441 | bioplex (OAS2) bioplex_WMM |
| OAS2 | GIMAP8 | 0.082 | 0.35 | bioplex (GIMAP8) bioplex_WMM |
| PTK2 | PRKG1 | 0.034 | 0.262 | bioplex (PRKG1) bioplex_WMM |
| OAS2 | PRKG1 | 0.028 | 0.232 | bioplex (OAS2) bioplex_WMM |
| ACACA | PRKG1 | 0.007 | 0.011 | bioplex_WMM WMM_only |
| PTK2 | ACACA | 0.007 | 0.002 | WMM_only |
Images
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Complex HuMAP2_04999 has an average edge precision of 0.216 which is ranked 5921 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ACACA | HuMAP2_03522 HuMAP2_04999 |
| PRKG1 | HuMAP2_04999 |
| GIMAP8 | HuMAP2_03522 HuMAP2_04999 |
| PTK2 | HuMAP2_01133 HuMAP2_04587 HuMAP2_04999 |
| OAS2 | HuMAP2_03522 HuMAP2_04999 |