hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05001
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GUCY1B1 | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) | UniProt NCBI |
| GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) | UniProt NCBI |
| GUCY1A2 | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | UniProt NCBI |
| MXRA7 | Matrix-remodeling-associated protein 7 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-392154 | 1.10114453861e-06 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Nitric oxide stimulates guanylate cyclase |
| WP:WP4222 | 2.58521566797e-06 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Phosphodiesterases in neuronal function |
| WP:WP4008 | 2.77896659511e-06 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | NO/cGMP/PKG mediated Neuroprotection |
| CORUM:408 | 5.02777038712e-06 | 0.5 | GUCY1B1 GUCY1A1 | Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) |
| CORUM:407 | 5.02777038712e-06 | 0.5 | GUCY1B1 GUCY1A2 | Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) |
| KEGG:04924 | 6.28787626438e-06 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Renin secretion |
| KEGG:04730 | 6.28787626438e-06 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Long-term depression |
| REAC:R-HSA-445355 | 7.35698811902e-06 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Smooth Muscle Contraction |
| GO:0004383 | 1.27120391093e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | guanylate cyclase activity |
| KEGG:04970 | 1.7381246657e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Salivary secretion |
| KEGG:04540 | 2.55355666749e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Gap junction |
| KEGG:04713 | 2.94026709165e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Circadian entrainment |
| KEGG:04270 | 4.20027475005e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Vascular smooth muscle contraction |
| KEGG:00230 | 5.93639809967e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Purine metabolism |
| KEGG:04611 | 5.93639809967e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Platelet activation |
| REAC:R-HSA-418346 | 9.84181176004e-05 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Platelet homeostasis |
| KEGG:04921 | 0.000107187194263 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Oxytocin signaling pathway |
| KEGG:04022 | 0.000122203178829 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | cGMP-PKG signaling pathway |
| GO:0016849 | 0.000296207880886 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | phosphorus-oxygen lyase activity |
| GO:0009975 | 0.000413778117181 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | cyclase activity |
| REAC:R-HSA-397014 | 0.00111581489513 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Muscle contraction |
| GO:0008074 | 0.00270494046827 | 0.5 | GUCY1B1 GUCY1A1 | guanylate cyclase complex, soluble |
| REAC:R-HSA-109582 | 0.033540764945 | 0.75 | GUCY1A2 GUCY1B1 GUCY1A1 | Hemostasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GUCY1B1 | GUCY1A1 | 0.999 | 0.949 | bioplex (GUCY1B1) bioplex_WMM |
| GUCY1B1 | GUCY1A2 | 0.993 | 0.918 | bioplex (GUCY1B1) bioplex_WMM |
| MXRA7 | GUCY1B1 | 0.826 | 0.774 | bioplex (GUCY1B1) bioplex_WMM |
| MXRA7 | GUCY1A2 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| MXRA7 | GUCY1A1 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| GUCY1A1 | GUCY1A2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05001 has an average edge precision of 0.487 which is ranked 2579 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GUCY1B1 | HuMAP2_02077 HuMAP2_05001 HuMAP2_05081 |
| GUCY1A1 | HuMAP2_02077 HuMAP2_05001 HuMAP2_05081 |
| GUCY1A2 | HuMAP2_02077 HuMAP2_05001 |
| MXRA7 | HuMAP2_02077 HuMAP2_05001 |