hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05012
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5229 | 2.25356268047e-10 | 1.0 | RPA1 RPA3 RPA2 | RPA complex |
| CORUM:2738 | 4.50712536095e-09 | 1.0 | RPA1 RPA3 RPA2 | BLM complex II |
| CORUM:2222 | 4.50712536095e-09 | 1.0 | RPA1 RPA3 RPA2 | BLM complex II |
| CORUM:248 | 1.8929926516e-08 | 1.0 | RPA1 RPA3 RPA2 | BRAFT complex |
| CORUM:244 | 3.71837842278e-08 | 1.0 | RPA1 RPA3 RPA2 | BRAFT complex |
| KEGG:03430 | 5.3258178191e-08 | 1.0 | RPA1 RPA3 RPA2 | Mismatch repair |
| REAC:R-HSA-174437 | 5.39516293207e-08 | 1.0 | RPA1 RPA3 RPA2 | Removal of the Flap Intermediate from the C-strand |
| CORUM:1005 | 6.44518926616e-08 | 1.0 | RPA1 RPA3 RPA2 | RC complex during G2/M-phase of cell cycle |
| CORUM:1004 | 6.44518926616e-08 | 1.0 | RPA1 RPA3 RPA2 | RC complex during S-phase of cell cycle |
| REAC:R-HSA-174414 | 7.41834903159e-08 | 1.0 | RPA1 RPA3 RPA2 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-3371511 | 9.89113204212e-08 | 1.0 | RPA1 RPA3 RPA2 | HSF1 activation |
| REAC:R-HSA-69166 | 1.63653275606e-07 | 1.0 | RPA1 RPA3 RPA2 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358606 | 1.63653275606e-07 | 1.0 | RPA1 RPA3 RPA2 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 1.63653275606e-07 | 1.0 | RPA1 RPA3 RPA2 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358508 | 2.04566594508e-07 | 1.0 | RPA1 RPA3 RPA2 | Mismatch Repair |
| REAC:R-HSA-69183 | 2.04566594508e-07 | 1.0 | RPA1 RPA3 RPA2 | Processive synthesis on the lagging strand |
| KEGG:03030 | 2.14716765829e-07 | 1.0 | RPA1 RPA3 RPA2 | DNA replication |
| REAC:R-HSA-110312 | 2.51774270163e-07 | 1.0 | RPA1 RPA3 RPA2 | Translesion synthesis by REV1 |
| KEGG:03440 | 2.97115076526e-07 | 1.0 | RPA1 RPA3 RPA2 | Homologous recombination |
| REAC:R-HSA-5656121 | 3.05725899484e-07 | 1.0 | RPA1 RPA3 RPA2 | Translesion synthesis by POLI |
| REAC:R-HSA-5655862 | 3.05725899484e-07 | 1.0 | RPA1 RPA3 RPA2 | Translesion synthesis by POLK |
| KEGG:03420 | 3.9827854995e-07 | 1.0 | RPA1 RPA3 RPA2 | Nucleotide excision repair |
| REAC:R-HSA-110320 | 4.35659406764e-07 | 1.0 | RPA1 RPA3 RPA2 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 5.12540478546e-07 | 1.0 | RPA1 RPA3 RPA2 | Lagging Strand Synthesis |
| KEGG:03460 | 5.54053458493e-07 | 1.0 | RPA1 RPA3 RPA2 | Fanconi anemia pathway |
| REAC:R-HSA-5651801 | 5.97963891637e-07 | 1.0 | RPA1 RPA3 RPA2 | PCNA-Dependent Long Patch Base Excision Repair |
| WP:WP466 | 7.39430675706e-07 | 1.0 | RPA1 RPA3 RPA2 | DNA Replication |
| REAC:R-HSA-174417 | 9.09984147875e-07 | 1.0 | RPA1 RPA3 RPA2 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-5696397 | 1.03407289531e-06 | 1.0 | RPA1 RPA3 RPA2 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 1.03407289531e-06 | 1.0 | RPA1 RPA3 RPA2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-110314 | 1.82536345868e-06 | 1.0 | RPA1 RPA3 RPA2 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 1.82536345868e-06 | 1.0 | RPA1 RPA3 RPA2 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 2.02093811497e-06 | 1.0 | RPA1 RPA3 RPA2 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 2.23000067859e-06 | 1.0 | RPA1 RPA3 RPA2 | DNA strand elongation |
| REAC:R-HSA-68962 | 2.45300074645e-06 | 1.0 | RPA1 RPA3 RPA2 | Activation of the pre-replicative complex |
| WP:WP45 | 2.55779891663e-06 | 1.0 | RPA1 RPA3 RPA2 | G1 to S cell cycle control |
| REAC:R-HSA-6783310 | 2.94261178253e-06 | 1.0 | RPA1 RPA3 RPA2 | Fanconi Anemia Pathway |
| REAC:R-HSA-73933 | 2.94261178253e-06 | 1.0 | RPA1 RPA3 RPA2 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5685938 | 3.21012194458e-06 | 1.0 | RPA1 RPA3 RPA2 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 3.49336799851e-06 | 1.0 | RPA1 RPA3 RPA2 | Activation of ATR in response to replication stress |
| REAC:R-HSA-110313 | 3.79279954124e-06 | 1.0 | RPA1 RPA3 RPA2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5693616 | 3.79279954124e-06 | 1.0 | RPA1 RPA3 RPA2 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 4.79270307132e-06 | 1.0 | RPA1 RPA3 RPA2 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5696400 | 4.79270307132e-06 | 1.0 | RPA1 RPA3 RPA2 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 5.54847547872e-06 | 1.0 | RPA1 RPA3 RPA2 | Formation of Incision Complex in GG-NER |
| WP:WP2446 | 6.82717373445e-06 | 1.0 | RPA1 RPA3 RPA2 | Retinoblastoma Gene in Cancer |
| REAC:R-HSA-73893 | 7.29021391195e-06 | 1.0 | RPA1 RPA3 RPA2 | DNA Damage Bypass |
| REAC:R-HSA-6782210 | 1.87320057001e-05 | 1.0 | RPA1 RPA3 RPA2 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 1.96383930727e-05 | 1.0 | RPA1 RPA3 RPA2 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-3371453 | 1.96383930727e-05 | 1.0 | RPA1 RPA3 RPA2 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-6782135 | 1.96383930727e-05 | 1.0 | RPA1 RPA3 RPA2 | Dual incision in TC-NER |
| CORUM:5231 | 3.35555483123e-05 | 0.666666666667 | RPA1 RPA2 | 53BP1-containing complex |
| REAC:R-HSA-6781827 | 3.42035346017e-05 | 1.0 | RPA1 RPA3 RPA2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 3.8359608447e-05 | 1.0 | RPA1 RPA3 RPA2 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 4.28393920683e-05 | 1.0 | RPA1 RPA3 RPA2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-3371556 | 4.44066869e-05 | 1.0 | RPA1 RPA3 RPA2 | Cellular response to heat stress |
| REAC:R-HSA-69002 | 4.44066869e-05 | 1.0 | RPA1 RPA3 RPA2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-912446 | 4.44066869e-05 | 1.0 | RPA1 RPA3 RPA2 | Meiotic recombination |
| REAC:R-HSA-73884 | 4.7655024582e-05 | 1.0 | RPA1 RPA3 RPA2 | Base Excision Repair |
| GO:0005662 | 5.08584025729e-05 | 1.0 | RPA1 RPA3 RPA2 | DNA replication factor A complex |
| REAC:R-HSA-6804756 | 5.46192807335e-05 | 1.0 | RPA1 RPA3 RPA2 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 6.02657683388e-05 | 1.0 | RPA1 RPA3 RPA2 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 6.62885685587e-05 | 1.0 | RPA1 RPA3 RPA2 | Processing of DNA double-strand break ends |
| REAC:R-HSA-73886 | 9.17879069632e-05 | 1.0 | RPA1 RPA3 RPA2 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 9.70320053332e-05 | 1.0 | RPA1 RPA3 RPA2 | Nucleotide Excision Repair |
| GO:0042276 | 0.000103533176666 | 1.0 | RPA1 RPA3 RPA2 | error-prone translesion synthesis |
| GO:0070987 | 0.000103533176666 | 1.0 | RPA1 RPA3 RPA2 | error-free translesion synthesis |
| REAC:R-HSA-1500620 | 0.000108111871608 | 1.0 | RPA1 RPA3 RPA2 | Meiosis |
| REAC:R-HSA-69239 | 0.000120004609098 | 1.0 | RPA1 RPA3 RPA2 | Synthesis of DNA |
| GO:0006293 | 0.000120788706111 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 0.000120788706111 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| REAC:R-HSA-69306 | 0.000146343794532 | 1.0 | RPA1 RPA3 RPA2 | DNA Replication |
| REAC:R-HSA-1474165 | 0.000149884370206 | 1.0 | RPA1 RPA3 RPA2 | Reproduction |
| GO:0006297 | 0.000160839698137 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair, DNA gap filling |
| REAC:R-HSA-5693567 | 0.000160847790881 | 1.0 | RPA1 RPA3 RPA2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-69206 | 0.000160847790881 | 1.0 | RPA1 RPA3 RPA2 | G1/S Transition |
| REAC:R-HSA-5693538 | 0.000184352717389 | 1.0 | RPA1 RPA3 RPA2 | Homology Directed Repair |
| GO:0043601 | 0.000208882724853 | 1.0 | RPA1 RPA3 RPA2 | nuclear replisome |
| REAC:R-HSA-453279 | 0.000233190181847 | 1.0 | RPA1 RPA3 RPA2 | Mitotic G1-G1/S phases |
| GO:0032201 | 0.000265644334868 | 1.0 | RPA1 RPA3 RPA2 | telomere maintenance via semi-conservative replication |
| GO:0030894 | 0.000265644334868 | 1.0 | RPA1 RPA3 RPA2 | replisome |
| REAC:R-HSA-5633007 | 0.000284464461562 | 1.0 | RPA1 RPA3 RPA2 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 0.000295546575822 | 1.0 | RPA1 RPA3 RPA2 | S Phase |
| REAC:R-HSA-5693532 | 0.000324502864875 | 1.0 | RPA1 RPA3 RPA2 | DNA Double-Strand Break Repair |
| GO:0006294 | 0.000331851076788 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair, preincision complex assembly |
| REAC:R-HSA-69481 | 0.00034275245309 | 1.0 | RPA1 RPA3 RPA2 | G2/M Checkpoints |
| GO:0006298 | 0.000408229499224 | 1.0 | RPA1 RPA3 RPA2 | mismatch repair |
| GO:0042769 | 0.000648444632805 | 1.0 | RPA1 RPA3 RPA2 | DNA damage response, detection of DNA damage |
| GO:0006296 | 0.0007056603357 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0006284 | 0.000766145507331 | 1.0 | RPA1 RPA3 RPA2 | base-excision repair |
| GO:0033683 | 0.000829990966275 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair, DNA incision |
| GO:0019985 | 0.000897287531108 | 1.0 | RPA1 RPA3 RPA2 | translesion synthesis |
| GO:0043596 | 0.000968126020406 | 1.0 | RPA1 RPA3 RPA2 | nuclear replication fork |
| GO:0000731 | 0.00137862598403 | 1.0 | RPA1 RPA3 RPA2 | DNA synthesis involved in DNA repair |
| GO:0036297 | 0.0015707980909 | 1.0 | RPA1 RPA3 RPA2 | interstrand cross-link repair |
| GO:0003684 | 0.00167324144465 | 1.0 | RPA1 RPA3 RPA2 | damaged DNA binding |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | RPA1 RPA3 RPA2 | Cell Cycle Checkpoints |
| GO:0006301 | 0.00178004409005 | 1.0 | RPA1 RPA3 RPA2 | postreplication repair |
| GO:0033260 | 0.00200709053011 | 1.0 | RPA1 RPA3 RPA2 | nuclear DNA replication |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | RPA1 RPA3 RPA2 | DNA Repair |
| GO:0044786 | 0.00251749092736 | 1.0 | RPA1 RPA3 RPA2 | cell cycle DNA replication |
| WP:WP4016 | 0.0028706736774 | 0.666666666667 | RPA1 RPA2 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | RPA1 RPA3 RPA2 | Transcriptional Regulation by TP53 |
| GO:0005657 | 0.00378386515143 | 1.0 | RPA1 RPA3 RPA2 | replication fork |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | RPA1 RPA3 RPA2 | Cellular responses to stress |
| GO:0090734 | 0.00564855215433 | 1.0 | RPA1 RPA3 RPA2 | site of DNA damage |
| GO:0006283 | 0.00564855215433 | 1.0 | RPA1 RPA3 RPA2 | transcription-coupled nucleotide-excision repair |
| GO:1900034 | 0.00638454589443 | 1.0 | RPA1 RPA3 RPA2 | regulation of cellular response to heat |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | RPA1 RPA3 RPA2 | Cellular responses to external stimuli |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | RPA1 RPA3 RPA2 | Cell Cycle, Mitotic |
| GO:0003697 | 0.0125706532002 | 1.0 | RPA1 RPA3 RPA2 | single-stranded DNA binding |
| GO:0034605 | 0.0160613559883 | 1.0 | RPA1 RPA3 RPA2 | cellular response to heat |
| GO:0006289 | 0.0170248502613 | 1.0 | RPA1 RPA3 RPA2 | nucleotide-excision repair |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | RPA1 RPA3 RPA2 | Cell Cycle |
| GO:0009408 | 0.0236246361809 | 1.0 | RPA1 RPA3 RPA2 | response to heat |
| GO:0000725 | 0.0268132763851 | 1.0 | RPA1 RPA3 RPA2 | recombinational repair |
| GO:0000724 | 0.0268132763851 | 1.0 | RPA1 RPA3 RPA2 | double-strand break repair via homologous recombination |
| GO:0006261 | 0.0302766427817 | 1.0 | RPA1 RPA3 RPA2 | DNA-dependent DNA replication |
| GO:0090305 | 0.0310032822085 | 1.0 | RPA1 RPA3 RPA2 | nucleic acid phosphodiester bond hydrolysis |
| GO:0032993 | 0.0380729634404 | 1.0 | RPA1 RPA3 RPA2 | protein-DNA complex |
| GO:0009266 | 0.0406485782564 | 1.0 | RPA1 RPA3 RPA2 | response to temperature stimulus |
| GO:0071897 | 0.043337807111 | 1.0 | RPA1 RPA3 RPA2 | DNA biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA3 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPA3 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_05012 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
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