hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05017
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EVA1C | Protein eva-1 homolog C (Protein FAM176C) (SUE21) | UniProt NCBI |
| COPZ1 | Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) | UniProt NCBI |
| COPB1 | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | UniProt NCBI |
| MAPRE2 | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | UniProt NCBI |
| SACM1L | Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein) | UniProt NCBI |
| ARCN1 | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | UniProt NCBI |
| COPG1 | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | UniProt NCBI |
| COPA | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | UniProt NCBI |
| COPB2 | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | UniProt NCBI |
| COPG2 | Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) | UniProt NCBI |
| COPE | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | UniProt NCBI |
| LETM1 | Mitochondrial proton/calcium exchanger protein (Leucine zipper-EF-hand-containing transmembrane protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030126 | 2.65242879445e-18 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | COPI vesicle coat |
| GO:0030663 | 3.1124213163e-17 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | COPI-coated vesicle membrane |
| GO:0030137 | 1.31584965069e-16 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | COPI-coated vesicle |
| GO:0030120 | 1.28627256089e-13 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | vesicle coat |
| REAC:R-HSA-6811434 | 2.58967700223e-13 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 2.82177938107e-13 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | COPI-mediated anterograde transport |
| GO:0006891 | 2.48574226982e-12 | 0.583333333333 | COPG1 COPA COPZ1 COPE COPG2 COPB1 COPB2 | intra-Golgi vesicle-mediated transport |
| REAC:R-HSA-8856688 | 3.14618100245e-12 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Golgi-to-ER retrograde transport |
| GO:0030117 | 5.46428886871e-12 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | membrane coat |
| GO:0048475 | 5.46428886871e-12 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | coated membrane |
| REAC:R-HSA-199977 | 7.26297992822e-12 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | ER to Golgi Anterograde Transport |
| GO:0006890 | 1.95066198144e-11 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| GO:0030660 | 2.15021388721e-11 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Golgi-associated vesicle membrane |
| REAC:R-HSA-948021 | 2.67671088342e-11 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6811442 | 9.28582267343e-11 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0030662 | 6.9345096521e-10 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | coated vesicle membrane |
| GO:0005798 | 9.4228091442e-10 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Golgi-associated vesicle |
| REAC:R-HSA-446203 | 1.82421159824e-09 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Asparagine N-linked glycosylation |
| GO:0006888 | 1.05751574195e-08 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0030135 | 3.10174582421e-08 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | coated vesicle |
| GO:0000139 | 8.32653424528e-08 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | Golgi membrane |
| GO:0030133 | 9.79745230445e-08 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | transport vesicle |
| REAC:R-HSA-199991 | 5.32445859995e-07 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 8.13235200545e-07 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Vesicle-mediated transport |
| GO:0048193 | 1.25338094023e-06 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Golgi vesicle transport |
| GO:0044431 | 2.6009134995e-06 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | Golgi apparatus part |
| GO:0005789 | 7.06708862427e-06 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | endoplasmic reticulum membrane |
| GO:0042175 | 8.17097673586e-06 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0030659 | 2.95295883051e-05 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | cytoplasmic vesicle membrane |
| GO:0012506 | 3.68924057085e-05 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | vesicle membrane |
| GO:0098796 | 6.84856435195e-05 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | membrane protein complex |
| GO:0044432 | 0.000114876014188 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | endoplasmic reticulum part |
| REAC:R-HSA-597592 | 0.00022396924712 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Post-translational protein modification |
| GO:0005794 | 0.000410031458353 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | Golgi apparatus |
| GO:0005783 | 0.00269698568838 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | endoplasmic reticulum |
| GO:0098588 | 0.00324498337892 | 0.75 | COPG1 COPB2 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | bounding membrane of organelle |
| REAC:R-HSA-392499 | 0.00354745382445 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | Metabolism of proteins |
| GO:0044433 | 0.0107389784918 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | cytoplasmic vesicle part |
| GO:0098805 | 0.0162298421097 | 0.666666666667 | COPG1 COPA COPZ1 COPE COPG2 COPB1 ARCN1 COPB2 | whole membrane |
| GO:0031090 | 0.0185226245312 | 0.833333333333 | COPG1 COPB2 LETM1 COPE COPZ1 COPG2 COPB1 SACM1L ARCN1 COPA | organelle membrane |
| GO:0051641 | 0.0186793423626 | 0.833333333333 | COPG1 COPB2 LETM1 COPE COPZ1 COPG2 MAPRE2 COPB1 ARCN1 COPA | cellular localization |
| GO:0051649 | 0.0335301337567 | 0.75 | COPG1 COPA COPZ1 LETM1 COPE COPG2 COPB1 ARCN1 COPB2 | establishment of localization in cell |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COPA | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM boldt youn_WMM hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | COPA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPA | ARCN1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| ARCN1 | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPA | COPB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (COPA) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB2 | COPG1 | 1.0 | 0.949 | hein_WMM bioplex (COPG1) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | ARCN1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPA | COPE | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (COPA) gupta_WMM fraction boldt_WMM |
| COPE | COPG1 | 0.992 | 0.911 | hein_WMM bioplex (COPG1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPB1 | COPB2 | 0.953 | 0.86 | hein_WMM bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB1 | COPE | 0.877 | 0.811 | hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| COPB2 | ARCN1 | 0.875 | 0.808 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPE | ARCN1 | 0.775 | 0.752 | hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| COPB2 | COPE | 0.596 | 0.666 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAPRE2 | COPA | 0.407 | 0.566 | youn_WMM gupta_WMM fraction |
| COPZ1 | COPA | 0.395 | 0.555 | hein_WMM bioplex_WMM boldt youn_WMM hein (COPA) gupta_WMM fraction boldt_WMM |
| MAPRE2 | COPG1 | 0.13 | 0.399 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SACM1L | COPG1 | 0.115 | 0.384 | hein_WMM bioplex (COPG1) bioplex_WMM hein (SACM1L) |
| SACM1L | ARCN1 | 0.084 | 0.349 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPZ1 | LETM1 | 0.073 | 0.355 | bioplex_WMM boldt fraction boldt_WMM |
| COPB2 | SACM1L | 0.068 | 0.348 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| SACM1L | COPE | 0.058 | 0.325 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPA | SACM1L | 0.045 | 0.283 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPG2 | SACM1L | 0.044 | 0.279 | hein_WMM bioplex_WMM hein (SACM1L) |
| MAPRE2 | ARCN1 | 0.043 | 0.27 | gupta_WMM fraction |
| COPZ1 | SACM1L | 0.037 | 0.265 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| EVA1C | SACM1L | 0.033 | 0.253 | bioplex (EVA1C) bioplex_WMM |
| COPB2 | COPG2 | 0.025 | 0.218 | hein_WMM bioplex_WMM boldt boldt_WMM treiber_WMM |
| COPB1 | SACM1L | 0.024 | 0.214 | hein_WMM bioplex_WMM hein (SACM1L) gupta_WMM |
| COPZ1 | COPG1 | 0.023 | 0.206 | hein_WMM bioplex (COPG1) bioplex_WMM youn_WMM gupta_WMM fraction |
| MAPRE2 | COPB1 | 0.023 | 0.209 | gupta_WMM fraction |
| COPZ1 | ARCN1 | 0.022 | 0.205 | hein_WMM bioplex_WMM gupta_WMM fraction treiber_WMM |
| COPZ1 | COPE | 0.015 | 0.14 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| COPB1 | COPG2 | 0.014 | 0.143 | hein_WMM bioplex_WMM boldt boldt_WMM treiber_WMM |
| MAPRE2 | COPB2 | 0.008 | 0.093 | youn_WMM gupta_WMM fraction |
| MAPRE2 | COPG2 | 0.007 | 0.005 | WMM_only |
| MAPRE2 | LETM1 | 0.007 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| LETM1 | COPA | 0.007 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| LETM1 | COPB2 | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only boldt_WMM |
| LETM1 | COPE | 0.007 | 0.0 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| LETM1 | COPG2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| MAPRE2 | SACM1L | 0.007 | 0.002 | gupta_WMM WMM_only |
| COPG2 | COPG1 | 0.007 | 0.005 | hein_WMM bioplex (COPG1) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| LETM1 | COPG1 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| LETM1 | ARCN1 | 0.007 | 0.004 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| LETM1 | COPB1 | 0.007 | 0.006 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| LETM1 | SACM1L | 0.007 | 0.004 | bioplex_WMM WMM_only |
| EVA1C | COPB1 | 0.005 | 0.008 | bioplex (EVA1C) bioplex_WMM |
| EVA1C | ARCN1 | 0.005 | 0.008 | bioplex (EVA1C) bioplex_WMM |
| MAPRE2 | COPE | 0.004 | 0.016 | bioplex_WMM youn_WMM gupta_WMM fraction |
| MAPRE2 | COPZ1 | 0.004 | 0.016 | bioplex_WMM youn_WMM gupta_WMM fraction |
| EVA1C | COPE | 0.004 | 0.009 | bioplex (EVA1C) bioplex_WMM |
| EVA1C | COPB2 | 0.004 | 0.014 | bioplex (EVA1C) |
| EVA1C | COPG2 | 0.004 | 0.009 | bioplex (EVA1C) bioplex_WMM |
| EVA1C | COPG1 | 0.003 | 0.01 | bioplex (EVA1C) bioplex_WMM |
| COPA | COPG2 | 0.0 | 0.014 | hein_WMM bioplex_WMM boldt hein (COPA) fraction boldt_WMM treiber_WMM |
| COPZ1 | COPB2 | 0.0 | 0.008 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| COPZ1 | COPG2 | 0.0 | 0.002 | hein_WMM bioplex_WMM fraction |
| EVA1C | COPA | 0.0 | 0.002 | bioplex (EVA1C) bioplex_WMM |
| COPG2 | COPE | 0.0 | 0.005 | hein_WMM bioplex_WMM boldt fraction boldt_WMM |
| COPZ1 | COPB1 | 0.0 | 0.0 | hein_WMM bioplex_WMM gupta_WMM fraction |
| COPG2 | ARCN1 | 0.0 | 0.001 | hein_WMM bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05017 has an average edge precision of 0.311 which is ranked 4446 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EVA1C | HuMAP2_00524 HuMAP2_05017 HuMAP2_06362 |
| COPZ1 | HuMAP2_01805 HuMAP2_05008 HuMAP2_05017 |
| COPB1 | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| MAPRE2 | HuMAP2_00486 HuMAP2_01478 HuMAP2_03288 HuMAP2_05017 |
| SACM1L | HuMAP2_03288 HuMAP2_05017 |
| ARCN1 | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| COPG1 | HuMAP2_03288 HuMAP2_04381 HuMAP2_05017 HuMAP2_06726 |
| COPA | HuMAP2_03288 HuMAP2_04381 HuMAP2_05017 HuMAP2_06726 |
| COPB2 | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| COPG2 | HuMAP2_03288 HuMAP2_05017 |
| COPE | HuMAP2_03288 HuMAP2_05017 HuMAP2_06726 |
| LETM1 | HuMAP2_01805 HuMAP2_05008 HuMAP2_05017 |