hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05031
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MT-ND1 | NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (NADH dehydrogenase subunit 1) | UniProt NCBI |
| STOML2 | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) | UniProt NCBI |
| NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) | UniProt NCBI |
| SLC25A11 | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11) | UniProt NCBI |
| NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit) | UniProt NCBI |
| NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit) | UniProt NCBI |
| NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-75kD) (CI-75kD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:178 | 1.19951464071e-10 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP623 | 6.33093772667e-10 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Oxidative phosphorylation |
| REAC:R-HSA-6799198 | 1.48746221904e-09 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Complex I biogenesis |
| WP:WP111 | 9.41786626552e-09 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Electron Transport Chain (OXPHOS system in mitochondria) |
| HP:0008972 | 1.24027962999e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 1.34892461275e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal activity of mitochondrial respiratory chain |
| KEGG:00190 | 3.11525631116e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Oxidative phosphorylation |
| REAC:R-HSA-611105 | 3.12678615465e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Respiratory electron transport |
| HP:0002490 | 3.1272250379e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Increased CSF lactate |
| HP:0030085 | 3.1272250379e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal CSF lactate level |
| KEGG:05012 | 4.34451200597e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Parkinson disease |
| KEGG:04723 | 5.49880601833e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Retrograde endocannabinoid signaling |
| HP:0025454 | 7.68084311933e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal CSF metabolite level |
| GO:0006119 | 7.96669644135e-08 | 0.857142857143 | NDUFB10 STOML2 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | oxidative phosphorylation |
| GO:0003954 | 8.60306456055e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | NADH dehydrogenase activity |
| GO:0008137 | 8.60306456055e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 8.60306456055e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | NADH dehydrogenase (quinone) activity |
| REAC:R-HSA-163200 | 9.11375597162e-08 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| HP:0002415 | 1.14013300029e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Leukodystrophy |
| GO:0030964 | 1.86011759625e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | NADH dehydrogenase complex |
| GO:0045271 | 1.86011759625e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | respiratory chain complex I |
| GO:0005747 | 1.86011759625e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial respiratory chain complex I |
| GO:0006120 | 2.09239754992e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0005743 | 2.23154164542e-07 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | mitochondrial inner membrane |
| WP:WP4324 | 2.63891133987e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Mitochondrial complex I assembly model OXPHOS system |
| HP:0012748 | 2.84166929299e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Focal T2 hyperintense brainstem lesion |
| HP:0008316 | 3.26213078063e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal mitochondria in muscle tissue |
| HP:0003287 | 3.78287071564e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of mitochondrial metabolism |
| GO:0019866 | 3.86088683525e-07 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | organelle inner membrane |
| CORUM:2904 | 4.0521314599e-07 | 0.428571428571 | MT-ND1 NDUFA9 NDUFV2 | Respiratory chain complex I (intermediate VII/650kD), mitochondrial |
| GO:0016655 | 4.44751203492e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| HP:0012747 | 4.80569950279e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal brainstem MRI signal intensity |
| REAC:R-HSA-1428517 | 5.41747192787e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0025116 | 5.42491392778e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Fetal distress |
| HP:0011923 | 5.42491392778e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Decreased activity of mitochondrial complex I |
| HP:0007704 | 5.42491392778e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Paroxysmal involuntary eye movements |
| CORUM:2905 | 5.57055794781e-07 | 0.428571428571 | MT-ND1 NDUFA9 NDUFV2 | Respiratory chain complex I (intermediate), mitochondrial |
| CORUM:2948 | 5.57055794781e-07 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Respiratory chain complex I (incomplete intermediate), mitochondrial |
| KEGG:04714 | 5.5808938506e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Thermogenesis |
| HP:0007183 | 6.10204296663e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Focal T2 hyperintense basal ganglia lesion |
| HP:0000114 | 6.84058004163e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Proximal tubulopathy |
| HP:0012103 | 9.25666117448e-07 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of the mitochondrion |
| HP:0004366 | 9.46109255889e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormality of glycolysis |
| HP:0003542 | 9.46109255889e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Increased serum pyruvate |
| HP:0012751 | 9.46109255889e-07 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Abnormal basal ganglia MRI signal intensity |
| GO:0010257 | 1.01702929659e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | NADH dehydrogenase complex assembly |
| GO:0032981 | 1.01702929659e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial respiratory chain complex I assembly |
| HP:0011013 | 1.68772628932e-06 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal circulating carbohydrate concentration |
| GO:0098803 | 1.78064392213e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | respiratory chain complex |
| GO:0005746 | 1.91954109347e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial respirasome |
| GO:0031966 | 1.97210997129e-06 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | mitochondrial membrane |
| GO:0070469 | 2.56432453108e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | respirasome |
| HP:0003737 | 2.79723647694e-06 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Mitochondrial myopathy |
| HP:0001138 | 2.79723647694e-06 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Optic neuropathy |
| GO:0005740 | 3.12357485887e-06 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | mitochondrial envelope |
| HP:0011400 | 3.23786775142e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal CNS myelination |
| GO:0042775 | 3.60213544234e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 3.84509079134e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | ATP synthesis coupled electron transport |
| GO:0046034 | 5.26515058595e-06 | 0.857142857143 | NDUFB10 STOML2 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | ATP metabolic process |
| GO:0016651 | 5.93698811276e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | oxidoreductase activity, acting on NAD(P)H |
| HP:0000817 | 6.1437116088e-06 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Poor eye contact |
| GO:1990204 | 6.67695565395e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | oxidoreductase complex |
| HP:0003800 | 6.98075896938e-06 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Muscle abnormality related to mitochondrial dysfunction |
| GO:0033108 | 7.48884975909e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial respiratory chain complex assembly |
| GO:0022904 | 7.92335684701e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | respiratory electron transport chain |
| HP:0001639 | 8.02447980444e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Hypertrophic cardiomyopathy |
| GO:0022900 | 8.37777986794e-06 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | electron transport chain |
| KEGG:04932 | 1.09194334287e-05 | 0.571428571429 | NDUFV2 NDUFS1 NDUFB10 NDUFA9 | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP4396 | 1.24852319142e-05 | 0.571428571429 | NDUFV2 NDUFS1 NDUFB10 NDUFA9 | Nonalcoholic fatty liver disease |
| HP:0000124 | 1.79845204771e-05 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Renal tubular dysfunction |
| HP:0000735 | 1.88920718153e-05 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Impaired social interactions |
| KEGG:05010 | 1.96839529328e-05 | 0.571428571429 | NDUFV2 NDUFS1 NDUFB10 NDUFA9 | Alzheimer disease |
| GO:0098800 | 2.49474542921e-05 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | inner mitochondrial membrane protein complex |
| HP:0001941 | 3.07466800472e-05 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Acidosis |
| KEGG:05016 | 3.36258525756e-05 | 0.571428571429 | NDUFV2 NDUFS1 NDUFB10 NDUFA9 | Huntington disease |
| HP:0000543 | 4.35545443137e-05 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Optic disc pallor |
| HP:0004360 | 4.75749508224e-05 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of acid-base homeostasis |
| GO:0044429 | 5.86181680769e-05 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | mitochondrial part |
| CORUM:2901 | 6.04024714829e-05 | 0.285714285714 | NDUFA9 MT-ND1 | Respiratory chain complex I (intermediate IV/310kD), mitochondrial |
| GO:0031975 | 7.6116924814e-05 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | envelope |
| GO:0031967 | 7.6116924814e-05 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | organelle envelope |
| GO:0045333 | 8.14657191312e-05 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | cellular respiration |
| GO:0006091 | 8.39154540724e-05 | 0.857142857143 | NDUFB10 STOML2 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | generation of precursor metabolites and energy |
| HP:0012433 | 9.5807681002e-05 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal social behavior |
| CORUM:2903 | 0.000100648251269 | 0.285714285714 | NDUFA9 MT-ND1 | Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial |
| HP:0012447 | 0.000117866947779 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal myelination |
| HP:0002421 | 0.000127038286476 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Poor head control |
| HP:0001254 | 0.000127038286476 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Lethargy |
| HP:0002921 | 0.000149065977285 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of the cerebrospinal fluid |
| HP:0002352 | 0.000156150597247 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Leukoencephalopathy |
| HP:0000580 | 0.000160683660729 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Pigmentary retinopathy |
| HP:0001638 | 0.000169043704026 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Cardiomyopathy |
| HP:0011017 | 0.000171153135621 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal cellular physiology |
| GO:0007005 | 0.000180678367325 | 0.857142857143 | NDUFB10 STOML2 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | mitochondrion organization |
| HP:0002363 | 0.000189980237885 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormality of brainstem morphology |
| HP:0002928 | 0.000191148776641 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Decreased activity of the pyruvate dehydrogenase complex |
| HP:0025354 | 0.000193422870499 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal cellular phenotype |
| HP:0002151 | 0.000195225771701 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Increased serum lactate |
| HP:0003128 | 0.000206040598494 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Lactic acidosis |
| CORUM:2884 | 0.000211266711219 | 0.285714285714 | NDUFA9 MT-ND1 | Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial |
| HP:0001637 | 0.000215383114772 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal myocardium morphology |
| HP:0002093 | 0.000239283704274 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Respiratory insufficiency |
| GO:0044455 | 0.000244186543029 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial membrane part |
| HP:0002134 | 0.000280613034148 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Abnormality of the basal ganglia |
| HP:0001943 | 0.00036516835121 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Hypoglycemia |
| GO:0015980 | 0.00042674062621 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | energy derivation by oxidation of organic compounds |
| CORUM:2919 | 0.000452410410067 | 0.285714285714 | NDUFA9 MT-ND1 | Respiratory chain complex I (gamma subunit) mitochondrial |
| HP:0011015 | 0.000498688127605 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal blood glucose concentration |
| HP:0002013 | 0.000509446300841 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Vomiting |
| HP:0000508 | 0.000591866065929 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Ptosis |
| HP:0012795 | 0.000632771024819 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of the optic disc |
| HP:0002104 | 0.000678977567411 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Apnea |
| HP:0000602 | 0.000734326859864 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Ophthalmoplegia |
| HP:0001298 | 0.000887402135879 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Encephalopathy |
| GO:0005739 | 0.000929815577583 | 1.0 | NDUFB10 STOML2 SLC25A11 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | mitochondrion |
| GO:0098798 | 0.000938903144903 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | mitochondrial protein complex |
| HP:0000618 | 0.000989970856888 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Blindness |
| HP:0007020 | 0.00112194860564 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Progressive spastic paraplegia |
| HP:0000597 | 0.00114016622244 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Ophthalmoparesis |
| CORUM:2920 | 0.00120480805051 | 0.285714285714 | NDUFS1 NDUFV2 | Respiratory chain complex I (lambda subunit) mitochondrial |
| HP:0000587 | 0.00141171984203 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of the optic nerve |
| HP:0004372 | 0.00215959234857 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Reduced consciousness/confusion |
| HP:0007703 | 0.00222393478709 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Abnormality of retinal pigmentation |
| HP:0002073 | 0.00257978907368 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Progressive cerebellar ataxia |
| HP:0000486 | 0.00265691508201 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Strabismus |
| HP:0000759 | 0.00281031639935 | 0.714285714286 | NDUFS1 SLC25A11 MT-ND1 NDUFA9 NDUFV2 | Abnormal peripheral nervous system morphology |
| HP:0001251 | 0.00284974260248 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Ataxia |
| HP:0001508 | 0.00301185730348 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Failure to thrive |
| HP:0002793 | 0.00307082516316 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Abnormal pattern of respiration |
| HP:0000549 | 0.00313817455891 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal conjugate eye movement |
| HP:0000819 | 0.00369155749436 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Diabetes mellitus |
| HP:0000639 | 0.00396130042672 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Nystagmus |
| HP:0001952 | 0.00408562509103 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Glucose intolerance |
| REAC:R-HSA-1430728 | 0.00415508232387 | 0.857142857143 | NDUFB10 NDUFS1 NDUFV2 MT-ND1 NDUFA9 SLC25A11 | Metabolism |
| HP:0012547 | 0.00422537949598 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal involuntary eye movements |
| KEGG:01100 | 0.00448611596597 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Metabolic pathways |
| HP:0002017 | 0.00490773389222 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Nausea and vomiting |
| HP:0011443 | 0.00497769634148 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of coordination |
| HP:0001332 | 0.00632800254594 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Dystonia |
| HP:0000729 | 0.00668926489507 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Autistic behavior |
| HP:0000712 | 0.00671844197849 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Emotional lability |
| HP:0010549 | 0.0068379729891 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Weakness due to upper motor neuron dysfunction |
| HP:0007663 | 0.00698912141419 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Reduced visual acuity |
| HP:0001511 | 0.0090950639533 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Intrauterine growth retardation |
| HP:0001258 | 0.00985419548449 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Spastic paraplegia |
| HP:0001098 | 0.0111076263652 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal fundus morphology |
| HP:0004329 | 0.0112833663238 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal posterior eye segment morphology |
| HP:0001260 | 0.0115278360327 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Dysarthria |
| HP:0001713 | 0.0115278360327 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Abnormal cardiac ventricle morphology |
| HP:0002795 | 0.0115811451167 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Functional respiratory abnormality |
| HP:0002240 | 0.0118626841802 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Hepatomegaly |
| GO:0098796 | 0.0126459869113 | 0.857142857143 | NDUFB10 STOML2 NDUFS1 NDUFV2 NDUFA9 MT-ND1 | membrane protein complex |
| HP:0000818 | 0.014264559781 | 0.714285714286 | NDUFS1 SLC25A11 MT-ND1 NDUFB10 NDUFV2 | Abnormality of the endocrine system |
| HP:0001626 | 0.0146817810963 | 0.857142857143 | NDUFB10 NDUFS1 NDUFV2 MT-ND1 NDUFA9 SLC25A11 | Abnormality of the cardiovascular system |
| HP:0001627 | 0.0149144426874 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal heart morphology |
| HP:0004325 | 0.01498807129 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Decreased body weight |
| HP:0031466 | 0.015621085794 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Impairment in personality functioning |
| HP:0010550 | 0.016876355253 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Paraplegia |
| HP:0011014 | 0.0176481559987 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal glucose homeostasis |
| HP:0011362 | 0.019050094925 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Abnormal hair quantity |
| HP:0000648 | 0.0192107975457 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Optic atrophy |
| HP:0012337 | 0.0212894272781 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal homeostasis |
| HP:0009830 | 0.0222785089839 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Peripheral neuropathy |
| HP:0000365 | 0.0223814807552 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Hearing impairment |
| HP:0031704 | 0.0238347752281 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormal ear physiology |
| HP:0000364 | 0.0238347752281 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Hearing abnormality |
| HP:0002061 | 0.0251576746332 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Lower limb spasticity |
| GO:0055114 | 0.0254241642855 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | oxidation-reduction process |
| HP:0000998 | 0.0256301546178 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Hypertrichosis |
| HP:0012211 | 0.026503020773 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormal renal physiology |
| HP:0003271 | 0.0271218216878 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Visceromegaly |
| HP:0012444 | 0.0324640689024 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Brain atrophy |
| HP:0012639 | 0.0357220456637 | 0.857142857143 | NDUFB10 NDUFS1 NDUFV2 MT-ND1 NDUFA9 SLC25A11 | Abnormality of nervous system morphology |
| HP:0010551 | 0.0363454816548 | 0.428571428571 | NDUFS1 NDUFA9 NDUFV2 | Paraplegia/paraparesis |
| HP:0000496 | 0.0371139930584 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of eye movement |
| HP:0001347 | 0.0382769804708 | 0.571428571429 | NDUFS1 MT-ND1 NDUFA9 NDUFV2 | Hyperreflexia |
| HP:0004323 | 0.0389592501743 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of body weight |
| HP:0001438 | 0.0393612957794 | 0.571428571429 | NDUFS1 MT-ND1 NDUFB10 NDUFV2 | Abnormality of abdomen morphology |
| HP:0030680 | 0.040876002412 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Abnormality of cardiovascular system morphology |
| HP:0000708 | 0.0416962216179 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Behavioral abnormality |
| HP:0002977 | 0.049298215699 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Aplasia/Hypoplasia involving the central nervous system |
| HP:0001252 | 0.0494871222508 | 0.714285714286 | NDUFV2 NDUFS1 MT-ND1 NDUFB10 NDUFA9 | Muscular hypotonia |
| CORUM:2943 | 0.0499886427319 | 0.142857142857 | MT-ND1 | Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFS1 | NDUFV2 | 0.896 | 0.821 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFS1 | STOML2 | 0.617 | 0.674 | hein_WMM bioplex (NDUFS1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFA9 | NDUFB10 | 0.334 | 0.527 | bioplex_WMM boldt fraction boldt_WMM |
| NDUFV2 | NDUFB10 | 0.239 | 0.469 | bioplex_WMM Guru fraction boldt_WMM |
| NDUFS1 | NDUFA9 | 0.224 | 0.466 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFS1 | NDUFB10 | 0.158 | 0.416 | bioplex_WMM Guru boldt fraction boldt_WMM |
| NDUFA9 | MT-ND1 | 0.093 | 0.355 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NDUFS1 | MT-ND1 | 0.085 | 0.349 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NDUFA9 | STOML2 | 0.07 | 0.349 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFA9 | NDUFV2 | 0.046 | 0.293 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFS1 | SLC25A11 | 0.04 | 0.268 | bioplex (NDUFS1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MT-ND1 | NDUFB10 | 0.039 | 0.266 | bioplex_WMM fraction |
| MT-ND1 | STOML2 | 0.039 | 0.266 | bioplex_WMM youn_WMM gupta_WMM fraction |
| MT-ND1 | NDUFV2 | 0.02 | 0.185 | bioplex_WMM gupta_WMM fraction |
| NDUFB10 | SLC25A11 | 0.02 | 0.187 | bioplex_WMM boldt fraction boldt_WMM |
| STOML2 | SLC25A11 | 0.013 | 0.149 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| MT-ND1 | SLC25A11 | 0.011 | 0.142 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NDUFB10 | STOML2 | 0.01 | 0.1 | bioplex_WMM boldt fraction boldt_WMM |
| NDUFV2 | SLC25A11 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| NDUFA9 | SLC25A11 | 0.006 | 0.006 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NDUFV2 | STOML2 | 0.0 | 0.017 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_05031 has an average edge precision of 0.3 which is ranked 4586 out of all 6965 complexes.
Related Complexes