hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05034
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| CLIC1 | Chloride intracellular channel protein 1 (Chloride channel ABP) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) | UniProt NCBI |
| NT5C3B | 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase) | UniProt NCBI |
| RPAIN | RPA-interacting protein (hRIP) | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | UniProt NCBI |
| TP53BP1 | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | UniProt NCBI |
| RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03420 | 2.13226551282e-09 | 0.5 | RPA2 RPA4 XPC RPA3 RPA1 | Nucleotide excision repair |
| CORUM:1005 | 5.43508641591e-09 | 0.4 | RPA2 PARP1 RPA3 RPA1 | RC complex during G2/M-phase of cell cycle |
| CORUM:1004 | 5.43508641591e-09 | 0.4 | RPA2 PARP1 RPA3 RPA1 | RC complex during S-phase of cell cycle |
| REAC:R-HSA-5696395 | 8.22641159017e-09 | 0.5 | RPA2 XPC PARP1 RPA3 RPA1 | Formation of Incision Complex in GG-NER |
| CORUM:5229 | 1.62176028613e-08 | 0.3 | RPA2 RPA3 RPA1 | RPA complex |
| KEGG:03430 | 4.33534708005e-08 | 0.4 | RPA2 RPA4 RPA3 RPA1 | Mismatch repair |
| GO:0090734 | 1.16202296463e-07 | 0.6 | RPA4 PARP1 TP53BP1 RPA2 RPA1 RPA3 | site of DNA damage |
| CORUM:5231 | 1.62061692851e-07 | 0.3 | RPA2 TP53BP1 RPA1 | 53BP1-containing complex |
| GO:0006294 | 2.43511577028e-07 | 0.5 | RPA2 XPC PARP1 RPA3 RPA1 | nucleotide-excision repair, preincision complex assembly |
| REAC:R-HSA-5696399 | 2.60814902534e-07 | 0.5 | RPA2 XPC PARP1 RPA3 RPA1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-110373 | 2.69327680603e-07 | 0.4 | RPA2 PARP1 RPA3 RPA1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 2.8718729628e-07 | 0.4 | RPA2 RPA4 RPA3 RPA1 | DNA replication |
| CORUM:2738 | 3.24009105225e-07 | 0.3 | RPA2 RPA3 RPA1 | BLM complex II |
| CORUM:2222 | 3.24009105225e-07 | 0.3 | RPA2 RPA3 RPA1 | BLM complex II |
| KEGG:03440 | 4.44990612757e-07 | 0.4 | RPA2 RPA4 RPA3 RPA1 | Homologous recombination |
| GO:0006310 | 4.89491670175e-07 | 0.7 | RPAIN PARP1 TP53BP1 RPA2 RPA1 RPA4 RPA3 | DNA recombination |
| WP:WP466 | 7.07162165532e-07 | 0.4 | RPA2 RPA4 RPA3 RPA1 | DNA Replication |
| REAC:R-HSA-68962 | 8.68969903058e-07 | 0.4 | RPA2 RPA4 RPA3 RPA1 | Activation of the pre-replicative complex |
| REAC:R-HSA-5696398 | 1.0264645659e-06 | 0.5 | RPA2 XPC PARP1 RPA3 RPA1 | Nucleotide Excision Repair |
| KEGG:03460 | 1.0286593557e-06 | 0.4 | RPA2 RPA4 RPA3 RPA1 | Fanconi anemia pathway |
| GO:0006289 | 1.09046376469e-06 | 0.6 | XPC RPA4 PARP1 RPA2 RPA1 RPA3 | nucleotide-excision repair |
| REAC:R-HSA-73933 | 1.11119006331e-06 | 0.4 | RPA2 PARP1 RPA3 RPA1 | Resolution of Abasic Sites (AP sites) |
| CORUM:248 | 1.35939923621e-06 | 0.3 | RPA2 RPA3 RPA1 | BRAFT complex |
| GO:0006281 | 1.52275413109e-06 | 0.8 | RPAIN PARP1 TP53BP1 RPA2 RPA1 RPA4 RPA3 XPC | DNA repair |
| REAC:R-HSA-5696400 | 2.14500437559e-06 | 0.4 | RPA2 PARP1 RPA3 RPA1 | Dual Incision in GG-NER |
| CORUM:244 | 2.66836560606e-06 | 0.3 | RPA2 RPA3 RPA1 | BRAFT complex |
| GO:0000724 | 2.72810322694e-06 | 0.6 | RPA4 PARP1 TP53BP1 RPA2 RPA1 RPA3 | double-strand break repair via homologous recombination |
| GO:0000725 | 2.72810322694e-06 | 0.6 | RPA4 PARP1 TP53BP1 RPA2 RPA1 RPA3 | recombinational repair |
| REAC:R-HSA-5693538 | 2.99664664154e-06 | 0.5 | RPA2 RPA1 PARP1 RPA3 TP53BP1 | Homology Directed Repair |
| REAC:R-HSA-73894 | 3.90842726551e-06 | 0.6 | XPC PARP1 TP53BP1 RPA2 RPA1 RPA3 | DNA Repair |
| REAC:R-HSA-174437 | 5.45842293653e-06 | 0.3 | RPA2 RPA3 RPA1 | Removal of the Flap Intermediate from the C-strand |
| GO:0035861 | 7.08151496511e-06 | 0.5 | RPA2 RPA4 PARP1 RPA3 TP53BP1 | site of double-strand break |
| REAC:R-HSA-174414 | 7.50268488399e-06 | 0.3 | RPA2 RPA3 RPA1 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-5693532 | 7.67886065968e-06 | 0.5 | RPA2 RPA1 PARP1 RPA3 TP53BP1 | DNA Double-Strand Break Repair |
| WP:WP4016 | 8.90776388583e-06 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | DNA IR-damage and cellular response via ATR |
| GO:0005662 | 9.28797042186e-06 | 0.4 | RPA2 RPA4 RPA3 RPA1 | DNA replication factor A complex |
| REAC:R-HSA-3371511 | 1.00000521116e-05 | 0.3 | RPA2 RPA3 RPA1 | HSF1 activation |
| REAC:R-HSA-69166 | 1.65338728209e-05 | 0.3 | RPA2 RPA3 RPA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358606 | 1.65338728209e-05 | 0.3 | RPA2 RPA3 RPA1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 1.65338728209e-05 | 0.3 | RPA2 RPA3 RPA1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358508 | 2.06600520876e-05 | 0.3 | RPA2 RPA3 RPA1 | Mismatch Repair |
| REAC:R-HSA-69183 | 2.06600520876e-05 | 0.3 | RPA2 RPA3 RPA1 | Processive synthesis on the lagging strand |
| REAC:R-HSA-110312 | 2.54187883076e-05 | 0.3 | RPA2 RPA3 RPA1 | Translesion synthesis by REV1 |
| GO:0006293 | 3.0493905917e-05 | 0.4 | RPA2 PARP1 RPA3 RPA1 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 3.0493905917e-05 | 0.4 | RPA2 PARP1 RPA3 RPA1 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| REAC:R-HSA-5655862 | 3.08547851834e-05 | 0.3 | RPA2 RPA3 RPA1 | Translesion synthesis by POLK |
| REAC:R-HSA-5656121 | 3.08547851834e-05 | 0.3 | RPA2 RPA3 RPA1 | Translesion synthesis by POLI |
| REAC:R-HSA-69002 | 4.22814532204e-05 | 0.4 | RPA2 RPA4 RPA3 RPA1 | DNA Replication Pre-Initiation |
| REAC:R-HSA-110320 | 4.39370578466e-05 | 0.3 | RPA2 RPA3 RPA1 | Translesion Synthesis by POLH |
| REAC:R-HSA-73884 | 4.64509548135e-05 | 0.4 | RPA2 PARP1 RPA3 RPA1 | Base Excision Repair |
| REAC:R-HSA-69186 | 5.16724233278e-05 | 0.3 | RPA2 RPA3 RPA1 | Lagging Strand Synthesis |
| GO:0006259 | 5.36366470765e-05 | 0.8 | RPAIN PARP1 TP53BP1 RPA2 RPA1 RPA4 RPA3 XPC | DNA metabolic process |
| GO:0006974 | 5.42393960193e-05 | 0.8 | RPAIN PARP1 TP53BP1 RPA2 RPA1 RPA4 RPA3 XPC | cellular response to DNA damage stimulus |
| REAC:R-HSA-5651801 | 6.0263228955e-05 | 0.3 | RPA2 RPA3 RPA1 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-69473 | 6.34943374718e-05 | 0.4 | RPA2 RPA1 RPA3 TP53BP1 | G2/M DNA damage checkpoint |
| GO:0043601 | 6.43693156641e-05 | 0.4 | RPA2 RPA4 RPA3 RPA1 | nuclear replisome |
| REAC:R-HSA-5693607 | 7.20721870542e-05 | 0.4 | RPA2 RPA1 RPA3 TP53BP1 | Processing of DNA double-strand break ends |
| GO:0030894 | 8.9245265137e-05 | 0.4 | RPA2 RPA4 RPA3 RPA1 | replisome |
| REAC:R-HSA-174417 | 9.16118331264e-05 | 0.3 | RPA2 RPA3 RPA1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-5696397 | 0.000104067629324 | 0.3 | RPA2 RPA3 RPA1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| GO:0003697 | 0.00011662858759 | 0.5 | RPA2 RPA4 XPC RPA3 RPA1 | single-stranded DNA binding |
| GO:0006302 | 0.000123439304249 | 0.6 | RPA4 PARP1 TP53BP1 RPA2 RPA1 RPA3 | double-strand break repair |
| GO:0006298 | 0.000159799391611 | 0.4 | RPA2 XPC RPA3 RPA1 | mismatch repair |
| REAC:R-HSA-110314 | 0.000183378151501 | 0.3 | RPA2 RPA3 RPA1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 0.000183378151501 | 0.3 | RPA2 RPA3 RPA1 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 0.000202954173087 | 0.3 | RPA2 RPA3 RPA1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69306 | 0.000206253548648 | 0.4 | RPA2 RPA4 RPA3 RPA1 | DNA Replication |
| REAC:R-HSA-69190 | 0.000223870409604 | 0.3 | RPA2 RPA3 RPA1 | DNA strand elongation |
| REAC:R-HSA-5693567 | 0.000233764083353 | 0.4 | RPA2 RPA1 RPA3 TP53BP1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-69206 | 0.000233764083353 | 0.4 | RPA2 RPA4 RPA3 RPA1 | G1/S Transition |
| REAC:R-HSA-6783310 | 0.000295097020196 | 0.3 | RPA2 RPA3 RPA1 | Fanconi Anemia Pathway |
| REAC:R-HSA-5685938 | 0.000321810414277 | 0.3 | RPA2 RPA3 RPA1 | HDR through Single Strand Annealing (SSA) |
| GO:0006296 | 0.000334769693204 | 0.4 | RPA2 PARP1 RPA3 RPA1 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| REAC:R-HSA-176187 | 0.00035008185877 | 0.3 | RPA2 RPA3 RPA1 | Activation of ATR in response to replication stress |
| REAC:R-HSA-5693616 | 0.000379954732889 | 0.3 | RPA2 RPA3 RPA1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-110313 | 0.000379954732889 | 0.3 | RPA2 RPA3 RPA1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-453279 | 0.000382153388735 | 0.4 | RPA2 RPA4 RPA3 RPA1 | Mitotic G1-G1/S phases |
| GO:0033683 | 0.000416645725181 | 0.4 | RPA2 PARP1 RPA3 RPA1 | nucleotide-excision repair, DNA incision |
| REAC:R-HSA-5693579 | 0.000479614787766 | 0.3 | RPA2 RPA3 RPA1 | Homologous DNA Pairing and Strand Exchange |
| GO:0006261 | 0.000507156872981 | 0.5 | RPA2 RPA4 RPA3 RPAIN RPA1 | DNA-dependent DNA replication |
| GO:0043596 | 0.000512656045765 | 0.4 | RPA2 RPA4 RPA3 RPA1 | nuclear replication fork |
| WP:WP45 | 0.000528977866642 | 0.3 | RPA2 RPA3 RPA1 | G1 to S cell cycle control |
| REAC:R-HSA-3108232 | 0.000620558627955 | 0.4 | PARP1 XPC TP53BP1 RPA1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-69481 | 0.000635580689275 | 0.4 | RPA2 RPA1 RPA3 TP53BP1 | G2/M Checkpoints |
| REAC:R-HSA-2990846 | 0.000714781788826 | 0.4 | PARP1 XPC TP53BP1 RPA1 | SUMOylation |
| REAC:R-HSA-73893 | 0.000728001600925 | 0.3 | RPA2 RPA3 RPA1 | DNA Damage Bypass |
| GO:0032993 | 0.000743117903262 | 0.5 | RPA2 RPA4 PARP1 RPA3 RPA1 | protein-DNA complex |
| GO:0000781 | 0.000799374810829 | 0.5 | RPA2 RPA4 PARP1 TP53BP1 RPA1 | chromosome, telomeric region |
| GO:0003684 | 0.00106980572992 | 0.4 | RPA2 XPC RPA3 RPA1 | damaged DNA binding |
| WP:WP2446 | 0.00140000217968 | 0.3 | RPA2 RPA3 RPA1 | Retinoblastoma Gene in Cancer |
| HPA:014010_12 | 0.00147597688315 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
| REAC:R-HSA-6782210 | 0.00185938291086 | 0.3 | RPA2 RPA3 RPA1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-3371453 | 0.00194866452029 | 0.3 | RPA2 RPA3 RPA1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-6782135 | 0.00194866452029 | 0.3 | RPA2 RPA3 RPA1 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 0.00194866452029 | 0.3 | RPA2 RPA3 RPA1 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-3108214 | 0.00254441551168 | 0.3 | PARP1 RPA1 XPC | SUMOylation of DNA damage response and repair proteins |
| GO:0005657 | 0.00319263270444 | 0.4 | RPA2 RPA4 RPA3 RPA1 | replication fork |
| HPA:048040_11 | 0.00334009933273 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | soft tissue 2; peripheral nerve[Supported,Low] |
| REAC:R-HSA-6781827 | 0.00337836977087 | 0.3 | RPA2 RPA3 RPA1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HPA:046010_12 | 0.00352057130049 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | smooth muscle; smooth muscle cells[Supported,Medium] |
| GO:0065004 | 0.00373493901659 | 0.5 | RPA2 XPC PARP1 RPA3 RPA1 | protein-DNA complex assembly |
| REAC:R-HSA-157579 | 0.00378486051784 | 0.3 | RPA2 RPA3 RPA1 | Telomere Maintenance |
| HPA:004010_11 | 0.00400541864789 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | breast; adipocytes[Supported,Low] |
| HPA:035010_12 | 0.0041083899212 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | placenta; decidual cells[Supported,Medium] |
| REAC:R-HSA-912446 | 0.00437532228124 | 0.3 | RPA2 RPA3 RPA1 | Meiotic recombination |
| REAC:R-HSA-3371556 | 0.00437532228124 | 0.3 | RPA2 RPA3 RPA1 | Cellular response to heat stress |
| REAC:R-HSA-1640170 | 0.00536344984968 | 0.5 | RPA2 RPA4 RPA1 RPA3 TP53BP1 | Cell Cycle |
| REAC:R-HSA-6804756 | 0.00537015050344 | 0.3 | RPA2 RPA3 RPA1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69620 | 0.00541336046982 | 0.4 | RPA2 RPA1 RPA3 TP53BP1 | Cell Cycle Checkpoints |
| HPA:027020_12 | 0.00555797820701 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.00601136385049 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skeletal muscle; myocytes[Supported,Medium] |
| GO:0006260 | 0.0060268547392 | 0.5 | RPA2 RPA4 RPA3 RPAIN RPA1 | DNA replication |
| HPA:011010_12 | 0.00620063401085 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | colon; endothelial cells[Supported,Medium] |
| HPA:048010_11 | 0.00644376153343 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | soft tissue 2; adipocytes[Supported,Low] |
| HPA:032020_12 | 0.0064932717269 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:035010_13 | 0.0079575479927 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | placenta; decidual cells[Supported,High] |
| HPA:014010_11 | 0.00824203602841 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 2; cells in endometrial stroma[Supported,Low] |
| HPA:026010_11 | 0.0083020737928 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | liver; bile duct cells[Supported,Low] |
| HPA:004030_12 | 0.00866953324677 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | breast; myoepithelial cells[Supported,Medium] |
| HPA:033010_12 | 0.00873199507374 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | parathyroid gland; glandular cells[Supported,Medium] |
| REAC:R-HSA-73886 | 0.00897046582916 | 0.3 | RPA2 RPA3 RPA1 | Chromosome Maintenance |
| HPA:043040_12 | 0.00911420639738 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skin 1; melanocytes[Supported,Medium] |
| HPA:011030_11 | 0.00931015946968 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | colon; peripheral nerve/ganglion[Supported,Low] |
| HPA:035010_11 | 0.00957654460201 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | placenta; decidual cells[Supported,Low] |
| HPA:009010_12 | 0.00971195520636 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cervix, uterine; glandular cells[Supported,Medium] |
| HPA:022010_11 | 0.0101271999314 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | hippocampus; glial cells[Supported,Low] |
| HPA:048030_11 | 0.0102686585575 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | soft tissue 2; fibroblasts[Supported,Low] |
| REAC:R-HSA-1500620 | 0.0105434097806 | 0.3 | RPA2 RPA3 RPA1 | Meiosis |
| HPA:007010_13 | 0.0112911790764 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | cerebellum; Purkinje cells[Supported,High] |
| GO:0071824 | 0.0113085018911 | 0.5 | RPA2 XPC PARP1 RPA3 RPA1 | protein-DNA complex subunit organization |
| HPA:058010_12 | 0.0113795728511 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | vagina; squamous epithelial cells[Supported,Medium] |
| REAC:R-HSA-69239 | 0.0116866754224 | 0.3 | RPA2 RPA3 RPA1 | Synthesis of DNA |
| HPA:043030_12 | 0.0121708949015 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skin 1; keratinocytes[Supported,Medium] |
| GO:0042276 | 0.0123497091753 | 0.3 | RPA2 RPA3 RPA1 | error-prone translesion synthesis |
| GO:0070987 | 0.0123497091753 | 0.3 | RPA2 RPA3 RPA1 | error-free translesion synthesis |
| HPA:048040_12 | 0.0123680266238 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | soft tissue 2; peripheral nerve[Supported,Medium] |
| HPA:031020_11 | 0.0125823524493 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | ovary; ovarian stroma cells[Supported,Low] |
| HPA:006010_11 | 0.0131765734396 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | caudate; glial cells[Supported,Low] |
| HPA:050020_11 | 0.0139725506586 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | spleen; cells in white pulp[Supported,Low] |
| HPA:014020_12 | 0.0142460571805 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 2; glandular cells[Supported,Medium] |
| HPA:030010_12 | 0.0144307058064 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | oral mucosa; squamous epithelial cells[Supported,Medium] |
| REAC:R-HSA-1474165 | 0.014550106919 | 0.3 | RPA2 RPA3 RPA1 | Reproduction |
| HPA:013010_11 | 0.0147111784574 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 1; cells in endometrial stroma[Supported,Low] |
| HPA:039010_12 | 0.015479957195 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | salivary gland; glandular cells[Supported,Medium] |
| HPA:007020_11 | 0.0158759233618 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cerebellum; cells in granular layer[Supported,Low] |
| HPA:008020_11 | 0.0161780525291 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cerebral cortex; glial cells[Supported,Low] |
| HPA:013020_12 | 0.0169004845213 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 1; glandular cells[Supported,Medium] |
| HPA:014010_02 | 0.0172176960007 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 2; cells in endometrial stroma[Uncertain,Medium] |
| HPA:047010_12 | 0.0178042136575 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | soft tissue 1; adipocytes[Supported,Medium] |
| HPA:053010_12 | 0.0179759331361 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | testis; Leydig cells[Supported,Medium] |
| HPA:040010_12 | 0.0186463636539 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | seminal vesicle; glandular cells[Supported,Medium] |
| HPA:024010_11 | 0.0187599722758 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | kidney; cells in glomeruli[Supported,Low] |
| HPA:007030_11 | 0.0191040403666 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cerebellum; cells in molecular layer[Supported,Low] |
| GO:0006297 | 0.019165085562 | 0.3 | RPA2 RPA3 RPA1 | nucleotide-excision repair, DNA gap filling |
| HPA:016010_12 | 0.0192198165307 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | esophagus; squamous epithelial cells[Supported,Medium] |
| HPA:032020_11 | 0.0193361391332 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | pancreas; islets of Langerhans[Supported,Low] |
| HPA:044010_12 | 0.019453010002 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skin 2; epidermal cells[Supported,Medium] |
| HPA:004020_12 | 0.0204079350423 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | breast; glandular cells[Supported,Medium] |
| HPA:011010_11 | 0.0205298231385 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | colon; endothelial cells[Supported,Low] |
| HPA:009010_11 | 0.0206522779712 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cervix, uterine; glandular cells[Supported,Low] |
| HPA:041010_11 | 0.0210230615647 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skeletal muscle; myocytes[Supported,Low] |
| HPA:026010_12 | 0.0213040822063 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | liver; bile duct cells[Supported,Medium] |
| HPA:004010_12 | 0.0215122205303 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | breast; adipocytes[Supported,Medium] |
| HPA:046010_11 | 0.0215254875973 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | smooth muscle; smooth muscle cells[Supported,Low] |
| HPA:015010_12 | 0.0219084090277 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | epididymis; glandular cells[Supported,Medium] |
| HPA:055010_12 | 0.0220372218764 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | thyroid gland; glandular cells[Supported,Medium] |
| HPA:053020_12 | 0.0220372218764 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | testis; cells in seminiferous ducts[Supported,Medium] |
| HPA:050010_11 | 0.0220372218764 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | spleen; cells in red pulp[Supported,Low] |
| HPA:004030_11 | 0.0221666240815 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | breast; myoepithelial cells[Supported,Low] |
| HPA:026020_11 | 0.0222966175504 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | liver; hepatocytes[Supported,Low] |
| HPA:032010_12 | 0.0222966175504 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | pancreas; exocrine glandular cells[Supported,Medium] |
| HPA:043040_11 | 0.0224272041942 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skin 1; melanocytes[Supported,Low] |
| HPA:027020_11 | 0.0224272041942 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | lung; pneumocytes[Supported,Low] |
| HPA:001040_12 | 0.0224272041942 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | adrenal gland; glandular cells[Supported,Medium] |
| HPA:035020_12 | 0.0228225423354 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | placenta; trophoblastic cells[Supported,Medium] |
| HPA:002010_12 | 0.0228225423354 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | appendix; glandular cells[Supported,Medium] |
| HPA:007010_11 | 0.0232232881754 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cerebellum; Purkinje cells[Supported,Low] |
| GO:0098687 | 0.0233146434038 | 0.5 | RPA2 RPA4 PARP1 TP53BP1 RPA1 | chromosomal region |
| HPA:029010_12 | 0.0233580808393 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | nasopharynx; respiratory epithelial cells[Supported,Medium] |
| HPA:033010_11 | 0.0233580808393 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | parathyroid gland; glandular cells[Supported,Low] |
| HPA:008030_13 | 0.0243556687721 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:021010_11 | 0.02663024958 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | heart muscle; myocytes[Supported,Low] |
| HPA:056010_11 | 0.0267801913425 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | tonsil; germinal center cells[Supported,Low] |
| GO:0033554 | 0.0269380657501 | 0.8 | RPAIN PARP1 TP53BP1 RPA2 RPA1 RPA4 RPA3 XPC | cellular response to stress |
| REAC:R-HSA-5633007 | 0.0273227523286 | 0.3 | RPA2 RPA3 RPA1 | Regulation of TP53 Activity |
| HPA:028020_11 | 0.0273865401789 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | lymph node; non-germinal center cells[Supported,Low] |
| HPA:052010_12 | 0.0276936921059 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | stomach 2; glandular cells[Supported,Medium] |
| HPA:057010_12 | 0.0276936921059 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | urinary bladder; urothelial cells[Supported,Medium] |
| HPA:005010_12 | 0.0276936921059 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | bronchus; respiratory epithelial cells[Supported,Medium] |
| HPA:018010_12 | 0.0278482695801 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | fallopian tube; glandular cells[Supported,Medium] |
| REAC:R-HSA-69242 | 0.0283670812811 | 0.3 | RPA2 RPA3 RPA1 | S Phase |
| HPA:058010_11 | 0.0286312539994 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | vagina; squamous epithelial cells[Supported,Low] |
| HPA:051010_12 | 0.0286312539994 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | stomach 1; glandular cells[Supported,Medium] |
| HPA:024020_12 | 0.0289491981238 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | kidney; cells in tubules[Supported,Medium] |
| HPA:048010_12 | 0.028993841744 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | soft tissue 2; adipocytes[Supported,Medium] |
| HPA:045010_12 | 0.0294312556459 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | small intestine; glandular cells[Supported,Medium] |
| HPA:008030_11 | 0.0294312556459 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | cerebral cortex; neuronal cells[Supported,Low] |
| HPA:043030_11 | 0.0297560791171 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skin 1; keratinocytes[Supported,Low] |
| HPA:056020_11 | 0.0299195326417 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | tonsil; non-germinal center cells[Supported,Low] |
| HPA:037010_12 | 0.0300836834791 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | rectum; glandular cells[Supported,Medium] |
| HPA:030010_11 | 0.0307473018966 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | oral mucosa; squamous epithelial cells[Supported,Low] |
| HPA:014020_11 | 0.0312524404652 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 2; glandular cells[Supported,Low] |
| HPA:012010_12 | 0.0312524404652 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | duodenum; glandular cells[Supported,Medium] |
| HPA:019010_12 | 0.0312524404652 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | gallbladder; glandular cells[Supported,Medium] |
| HPA:003010_11 | 0.0315927668105 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | bone marrow; hematopoietic cells[Supported,Low] |
| GO:0032201 | 0.0316085885479 | 0.3 | RPA2 RPA3 RPA1 | telomere maintenance via semi-conservative replication |
| HPA:036010_11 | 0.0319359668097 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | prostate; glandular cells[Supported,Low] |
| HPA:039010_11 | 0.0326310560094 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | salivary gland; glandular cells[Supported,Low] |
| HPA:040010_11 | 0.0329829794679 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | seminal vesicle; glandular cells[Supported,Low] |
| HPA:013020_11 | 0.0335163866185 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | endometrium 1; glandular cells[Supported,Low] |
| HPA:004020_11 | 0.0342379946156 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | breast; glandular cells[Supported,Low] |
| HPA:029010_11 | 0.0342379946156 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | nasopharynx; respiratory epithelial cells[Supported,Low] |
| HPA:055010_11 | 0.0342379946156 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | thyroid gland; glandular cells[Supported,Low] |
| HPA:016010_11 | 0.0344202679535 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | esophagus; squamous epithelial cells[Supported,Low] |
| HPA:044010_11 | 0.0346032941835 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | skin 2; epidermal cells[Supported,Low] |
| HPA:055010_13 | 0.0348376597882 | 0.4 | RPA2 XPC TP53BP1 RPA1 | thyroid gland; glandular cells[Supported,High] |
| HPA:053020_13 | 0.0351357795005 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | testis; cells in seminiferous ducts[Supported,High] |
| HPA:002010_11 | 0.0353429717627 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | appendix; glandular cells[Supported,Low] |
| HPA:032010_11 | 0.035905742692 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | pancreas; exocrine glandular cells[Supported,Low] |
| HPA:001040_11 | 0.036475447815 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | adrenal gland; glandular cells[Supported,Low] |
| WP:WP3959 | 0.0369034425738 | 0.2 | PARP1 TP53BP1 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| HPA:035020_11 | 0.0372459445976 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | placenta; trophoblastic cells[Supported,Low] |
| HPA:053010_11 | 0.0374405282662 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | testis; Leydig cells[Supported,Low] |
| HPA:018010_11 | 0.0374405282662 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | fallopian tube; glandular cells[Supported,Low] |
| HPA:015010_11 | 0.0382267679178 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | epididymis; glandular cells[Supported,Low] |
| HPA:011020_11 | 0.038824810785 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | colon; glandular cells[Supported,Low] |
| HPA:035010_03 | 0.0391830631353 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | placenta; decidual cells[Uncertain,High] |
| HPA:057010_11 | 0.0394300897283 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | urinary bladder; urothelial cells[Supported,Low] |
| HPA:053020_11 | 0.0394300897283 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | testis; cells in seminiferous ducts[Supported,Low] |
| HPA:019010_11 | 0.0394300897283 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | gallbladder; glandular cells[Supported,Low] |
| HPA:005010_11 | 0.0396334679653 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | bronchus; respiratory epithelial cells[Supported,Low] |
| HPA:037010_11 | 0.0398376592841 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | rectum; glandular cells[Supported,Low] |
| HPA:051010_11 | 0.0406626009815 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | stomach 1; glandular cells[Supported,Low] |
| HPA:052010_11 | 0.0423522079783 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | stomach 2; glandular cells[Supported,Low] |
| HPA:012010_11 | 0.0425671778734 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | duodenum; glandular cells[Supported,Low] |
| HPA:045010_11 | 0.0429996558327 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | small intestine; glandular cells[Supported,Low] |
| HPA:022010_12 | 0.044264016055 | 0.4 | RPA2 XPC TP53BP1 RPA1 | hippocampus; glial cells[Supported,Medium] |
| HPA:024020_11 | 0.0456665738307 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | kidney; cells in tubules[Supported,Low] |
| HPA:029010_13 | 0.0456962784067 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0460595555119 | 0.4 | RPA2 PARP1 TP53BP1 RPA1 | bronchus; respiratory epithelial cells[Supported,High] |
| HPA:035010_10 | 0.0499053528258 | 0.5 | RPA2 XPC PARP1 TP53BP1 RPA1 | placenta; decidual cells[Supported,Not detected] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA3 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPA3 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RPA2 | TP53BP1 | 0.312 | 0.505 | bioplex_WMM youn_WMM fraction |
| RPA2 | RPAIN | 0.304 | 0.499 | bioplex (RPA2,RPAIN) bioplex_WMM |
| RPA2 | XPC | 0.171 | 0.43 | bioplex (RPA2,XPC) bioplex_WMM |
| PARP1 | RPA2 | 0.165 | 0.42 | bioplex (RPA2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | RPA4 | 0.128 | 0.399 | bioplex (RPA4) bioplex_WMM |
| PARP1 | XPC | 0.112 | 0.381 | bioplex (XPC) bioplex_WMM gupta_WMM |
| PARP1 | RPA1 | 0.104 | 0.368 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPA1 | CLIC1 | 0.103 | 0.366 | bioplex_WMM youn_WMM gupta_WMM fraction |
| RPA1 | RPA4 | 0.1 | 0.361 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA3 | 0.1 | 0.36 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| RPA3 | CLIC1 | 0.099 | 0.358 | bioplex_WMM youn_WMM gupta_WMM fraction |
| RPA1 | TP53BP1 | 0.076 | 0.355 | youn_WMM gupta_WMM fraction |
| NT5C3B | TP53BP1 | 0.06 | 0.337 | fraction |
| RPA1 | XPC | 0.048 | 0.294 | bioplex (XPC) bioplex_WMM gupta_WMM |
| RPA3 | RPAIN | 0.041 | 0.27 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | RPAIN | 0.034 | 0.257 | bioplex (RPAIN) bioplex_WMM |
| RPA3 | XPC | 0.024 | 0.211 | bioplex (XPC) bioplex_WMM |
| RPA3 | TP53BP1 | 0.007 | 0.009 | youn_WMM WMM_only |
| RPAIN | XPC | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PARP1 | TP53BP1 | 0.007 | 0.012 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| PARP1 | CLIC1 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TP53BP1 | CLIC1 | 0.007 | 0.005 | youn_WMM WMM_only |
| XPC | CLIC1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| RPA2 | RPA4 | 0.006 | 0.004 | bioplex (RPA4) bioplex_WMM |
| RPAIN | CLIC1 | 0.006 | 0.003 | bioplex (RPAIN) |
| PARP1 | RPA4 | 0.005 | 0.013 | bioplex (RPA4) bioplex_WMM |
| RPA4 | XPC | 0.004 | 0.013 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPAIN | 0.0 | 0.017 | bioplex (RPAIN) bioplex_WMM |
| RPA2 | CLIC1 | 0.0 | 0.001 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_05034 has an average edge precision of 0.284 which is ranked 4818 out of all 6965 complexes.
Related Complexes