hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05036
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBR5 | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | UniProt NCBI |
| EEF1A1 | Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | UniProt NCBI |
| EEF1A2 | Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | UniProt NCBI |
| EEF1B2 | Elongation factor 1-beta (EF-1-beta) | UniProt NCBI |
| EEF1G | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | UniProt NCBI |
| VARS | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | UniProt NCBI |
| EIF5B | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | UniProt NCBI |
| KTN1 | Kinectin (CG-1 antigen) (Kinesin receptor) | UniProt NCBI |
| PBDC1 | Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) | UniProt NCBI |
| EEF1D | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | UniProt NCBI |
| CARS | Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) | UniProt NCBI |
| MSH2 | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 6.42522926662e-11 | 0.5 | EEF1A2 EEF1B2 EIF5B EEF1G EEF1D EEF1A1 | Translation Factors |
| REAC:R-HSA-72766 | 2.097595978e-09 | 0.666666666667 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 | Translation |
| CORUM:1335 | 3.54593011291e-08 | 0.333333333333 | EEF1G UBR5 EEF1A1 MSH2 | SNW1 complex |
| REAC:R-HSA-156842 | 1.48959591838e-06 | 0.416666666667 | EEF1A2 EEF1G EEF1D EEF1A1 EEF1B2 | Eukaryotic Translation Elongation |
| GO:0005853 | 1.99800867251e-05 | 0.25 | EEF1B2 EEF1D EEF1A1 | eukaryotic translation elongation factor 1 complex |
| GO:0006412 | 4.05075591198e-05 | 0.666666666667 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 | translation |
| GO:0043043 | 5.73824055582e-05 | 0.666666666667 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 | peptide biosynthetic process |
| GO:0008135 | 8.23133181182e-05 | 0.416666666667 | EEF1A2 EIF5B EEF1D EEF1A1 EEF1B2 | translation factor activity, RNA binding |
| REAC:R-HSA-392499 | 0.000212678742663 | 0.75 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 KTN1 | Metabolism of proteins |
| GO:0090079 | 0.000232136090194 | 0.416666666667 | EEF1A2 EIF5B EEF1D EEF1A1 EEF1B2 | translation regulator activity, nucleic acid binding |
| GO:0043604 | 0.000239457657464 | 0.666666666667 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 | amide biosynthetic process |
| GO:0006518 | 0.000248437709733 | 0.666666666667 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 | peptide metabolic process |
| KEGG:05134 | 0.000270399111681 | 0.25 | EEF1A2 EEF1A1 EEF1G | Legionellosis |
| GO:0045182 | 0.000761991390548 | 0.416666666667 | EEF1A2 EIF5B EEF1D EEF1A1 EEF1B2 | translation regulator activity |
| GO:0006414 | 0.00118184639008 | 0.416666666667 | EEF1A2 EEF1G EEF1D EEF1A1 EEF1B2 | translational elongation |
| GO:0043603 | 0.00191112425712 | 0.666666666667 | EEF1B2 EEF1A2 CARS VARS EEF1G EEF1D EIF5B EEF1A1 | cellular amide metabolic process |
| GO:0003746 | 0.00723656577432 | 0.25 | EEF1A2 EEF1A1 EEF1B2 | translation elongation factor activity |
| KEGG:03013 | 0.00993066028977 | 0.25 | EEF1A2 EIF5B EEF1A1 | RNA transport |
| KEGG:00970 | 0.0251120616417 | 0.166666666667 | CARS VARS | Aminoacyl-tRNA biosynthesis |
| REAC:R-HSA-379716 | 0.0392835928601 | 0.166666666667 | CARS VARS | Cytosolic tRNA aminoacylation |
| KEGG:05140 | 0.0421208202383 | 0.166666666667 | EEF1A2 EEF1A1 | Leishmaniasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EEF1B2 | EEF1A1 | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1) bioplex_WMM Guru boldt hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| EEF1A1 | EEF1D | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1,EEF1D) bioplex_WMM boldt hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| VARS | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1G) bioplex_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1D | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1D,EEF1G) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A1 | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1,EEF1G) bioplex_WMM Guru boldt hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| VARS | EEF1A1 | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1) bioplex_WMM hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| VARS | EEF1D | 1.0 | 0.949 | hein_WMM bioplex (EEF1D) bioplex_WMM Malo gupta_WMM fraction boldt_WMM |
| EEF1B2 | VARS | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo gupta_WMM fraction boldt_WMM |
| EEF1B2 | EEF1D | 1.0 | 0.949 | hein_WMM bioplex (EEF1D) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1B2 | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1G) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A2 | PBDC1 | 0.99 | 0.908 | bioplex (EEF1A2,PBDC1) bioplex_WMM fraction |
| EEF1A2 | EEF1G | 0.982 | 0.898 | bioplex (EEF1A2,EEF1G) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| PBDC1 | EEF1A1 | 0.954 | 0.861 | bioplex (EEF1A1,PBDC1) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| CARS | EEF1A1 | 0.741 | 0.74 | hein_WMM bioplex (EEF1A1) bioplex_WMM hein (EEF1A1) fraction boldt_WMM treiber_WMM |
| EEF1B2 | EIF5B | 0.628 | 0.68 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EEF1A2 | EEF1A1 | 0.397 | 0.557 | bioplex (EEF1A1,EEF1A2) bioplex_WMM treiber_WMM |
| CARS | EEF1D | 0.32 | 0.512 | hein_WMM bioplex (EEF1D) bioplex_WMM boldt_WMM |
| CARS | EEF1G | 0.21 | 0.457 | hein_WMM bioplex (EEF1G) bioplex_WMM fraction boldt_WMM treiber_WMM |
| EEF1D | EIF5B | 0.145 | 0.408 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EEF1G | KTN1 | 0.127 | 0.399 | hein_WMM bioplex (EEF1G) bioplex_WMM youn_WMM hein (KTN1) gupta_WMM treiber_WMM |
| UBR5 | EEF1A1 | 0.118 | 0.391 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| EEF1D | KTN1 | 0.108 | 0.373 | hein_WMM bioplex (EEF1D) bioplex_WMM youn_WMM hein (KTN1) gupta_WMM |
| EEF1G | EIF5B | 0.107 | 0.372 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A2 | CARS | 0.103 | 0.366 | bioplex (EEF1A2) bioplex_WMM fraction |
| EEF1A2 | VARS | 0.074 | 0.357 | bioplex (EEF1A2) bioplex_WMM fraction |
| EEF1A1 | MSH2 | 0.071 | 0.353 | bioplex (EEF1A1) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| EEF1A2 | EEF1D | 0.044 | 0.275 | bioplex (EEF1A2,EEF1D) bioplex_WMM youn_WMM treiber_WMM |
| UBR5 | EEF1G | 0.037 | 0.265 | bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| EEF1A1 | KTN1 | 0.016 | 0.159 | hein_WMM bioplex (EEF1A1) bioplex_WMM boldt hein (EEF1A1) boldt_WMM treiber_WMM |
| UBR5 | EEF1A2 | 0.015 | 0.143 | bioplex_WMM fraction |
| VARS | KTN1 | 0.009 | 0.102 | hein_WMM bioplex_WMM hein (KTN1) treiber_WMM |
| UBR5 | MSH2 | 0.009 | 0.09 | bioplex_WMM youn_WMM fraction |
| CARS | KTN1 | 0.008 | 0.026 | hein_WMM bioplex_WMM WMM_only treiber_WMM |
| MSH2 | EIF5B | 0.007 | 0.006 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| EEF1A1 | EIF5B | 0.007 | 0.004 | boldt boldt_WMM treiber_WMM |
| EEF1G | MSH2 | 0.007 | 0.017 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| EEF1A2 | MSH2 | 0.007 | 0.006 | youn_WMM WMM_only |
| EEF1B2 | MSH2 | 0.007 | 0.003 | boldt youn_WMM gupta_WMM boldt_WMM |
| PBDC1 | EEF1G | 0.007 | 0.002 | bioplex (PBDC1) bioplex_WMM |
| UBR5 | PBDC1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| VARS | EIF5B | 0.007 | 0.007 | gupta_WMM WMM_only boldt_WMM treiber_WMM |
| CARS | MSH2 | 0.007 | 0.004 | bioplex_WMM WMM_only boldt_WMM treiber_WMM |
| EEF1D | MSH2 | 0.007 | 0.004 | boldt youn_WMM gupta_WMM boldt_WMM |
| PBDC1 | MSH2 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| UBR5 | EEF1B2 | 0.007 | 0.002 | bioplex_WMM boldt youn_WMM boldt_WMM |
| EIF5B | KTN1 | 0.007 | 0.001 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| PBDC1 | KTN1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| UBR5 | CARS | 0.007 | 0.001 | bioplex_WMM WMM_only |
| UBR5 | VARS | 0.007 | 0.001 | bioplex_WMM WMM_only |
| PBDC1 | EEF1B2 | 0.007 | 0.006 | bioplex (PBDC1) bioplex_WMM |
| EEF1A2 | EIF5B | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| PBDC1 | EEF1D | 0.007 | 0.003 | bioplex (PBDC1) bioplex_WMM treiber_WMM |
| UBR5 | KTN1 | 0.006 | 0.011 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PBDC1 | EIF5B | 0.005 | 0.008 | bioplex_WMM WMM_only |
| UBR5 | EEF1D | 0.005 | 0.006 | hein_WMM bioplex (EEF1D) bioplex_WMM boldt youn_WMM boldt_WMM |
| EEF1A2 | EEF1B2 | 0.004 | 0.012 | bioplex (EEF1A2) bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| VARS | MSH2 | 0.004 | 0.01 | gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A2 | KTN1 | 0.004 | 0.017 | bioplex (EEF1A2) bioplex_WMM youn_WMM |
| EEF1B2 | KTN1 | 0.0 | 0.012 | hein_WMM bioplex_WMM youn_WMM hein (KTN1) gupta_WMM |
| CARS | EEF1B2 | 0.0 | 0.01 | hein_WMM bioplex_WMM fraction boldt_WMM |
| CARS | EIF5B | 0.0 | 0.009 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| UBR5 | EIF5B | 0.0 | 0.0 | hein_WMM bioplex_WMM youn_WMM fraction treiber_WMM |
| CARS | VARS | 0.0 | 0.001 | hein_WMM bioplex_WMM fraction boldt_WMM treiber_WMM |
| PBDC1 | CARS | 0.0 | 0.001 | bioplex_WMM fraction |
| MSH2 | KTN1 | 0.0 | 0.0 | bioplex_WMM youn_WMM fraction treiber_WMM |
| PBDC1 | VARS | 0.0 | 0.0 | bioplex_WMM fraction |
Images
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Complex HuMAP2_05036 has an average edge precision of 0.293 which is ranked 4697 out of all 6965 complexes.
Related Complexes