hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05042
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CSNK2B | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | UniProt NCBI |
| PCGF5 | Polycomb group RING finger protein 5 (RING finger protein 159) | UniProt NCBI |
| NKAPD1 | Uncharacterized protein NKAPD1 (NKAP domain containing protein 1) | UniProt NCBI |
| CSNK2A2 | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | UniProt NCBI |
| CSNK2A1 | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | UniProt NCBI |
| VSX1 | Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1) | UniProt NCBI |
| NKAP | NF-kappa-B-activating protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2720 | 3.38154272427e-09 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:5224 | 3.38154272427e-09 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:2719 | 1.3523445861e-08 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Casein kinase II-HMG1 complex |
| CORUM:938 | 3.38018031602e-08 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | FACT complex, UV-activated |
| REAC:R-HSA-8939243 | 1.67346997747e-07 | 0.571428571429 | CSNK2A2 PCGF5 CSNK2B CSNK2A1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-201688 | 5.94732974666e-07 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | WNT mediated activation of DVL |
| REAC:R-HSA-8934903 | 8.91919699889e-07 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Receptor Mediated Mitophagy |
| REAC:R-HSA-2514853 | 1.75127908727e-06 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Condensation of Prometaphase Chromosomes |
| CORUM:5223 | 1.007158685e-05 | 0.285714285714 | CSNK2A2 CSNK2B | Casein kinase II (beta-dimer, alpha'-dimer) |
| CORUM:5225 | 1.007158685e-05 | 0.285714285714 | CSNK2A1 CSNK2B | Casein kinase II (beta-dimer, alpha-dimer) |
| REAC:R-HSA-445144 | 1.20778145331e-05 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Signal transduction by L1 |
| REAC:R-HSA-5205647 | 2.14261301225e-05 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Mitophagy |
| REAC:R-HSA-1483191 | 2.75125863862e-05 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Synthesis of PC |
| REAC:R-HSA-6814122 | 9.645347366e-05 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| KEGG:04137 | 0.000124522301094 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Mitophagy - animal |
| GO:0031519 | 0.000138393555724 | 0.571428571429 | CSNK2A2 PCGF5 CSNK2B CSNK2A1 | PcG protein complex |
| KEGG:04520 | 0.00017226343857 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Adherens junction |
| KEGG:03008 | 0.000240117545455 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Ribosome biogenesis in eukaryotes |
| WP:WP4336 | 0.000253390302973 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| REAC:R-HSA-8878171 | 0.000257145777466 | 0.571428571429 | CSNK2A2 PCGF5 CSNK2B CSNK2A1 | Transcriptional regulation by RUNX1 |
| KEGG:04064 | 0.000259474808627 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | NF-kappa B signaling pathway |
| KEGG:05235 | 0.000269529738666 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP4258 | 0.000352401426229 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-8948751 | 0.000525839100255 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Regulation of PTEN stability and activity |
| WP:WP428 | 0.000657238949319 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Wnt Signaling |
| REAC:R-HSA-1632852 | 0.00110788408246 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Macroautophagy |
| KEGG:05162 | 0.00110907784383 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Measles |
| REAC:R-HSA-390466 | 0.00122718339452 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Chaperonin-mediated protein folding |
| REAC:R-HSA-6804756 | 0.00126876263254 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Regulation of TP53 Activity through Phosphorylation |
| WP:WP4262 | 0.00144093759847 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Breast cancer pathway |
| REAC:R-HSA-391251 | 0.00149069932759 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Protein folding |
| KEGG:04310 | 0.00167858916845 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Wnt signaling pathway |
| REAC:R-HSA-9612973 | 0.00184251586032 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Autophagy |
| REAC:R-HSA-1483206 | 0.00206623616174 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Glycerophospholipid biosynthesis |
| REAC:R-HSA-373760 | 0.00230723415657 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | L1CAM interactions |
| REAC:R-HSA-6807070 | 0.0041507778953 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | PTEN Regulation |
| REAC:R-HSA-5633007 | 0.00652017227538 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.0104680278884 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Phospholipid metabolism |
| REAC:R-HSA-68877 | 0.0116992025039 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Mitotic Prometaphase |
| GO:0006656 | 0.0128352677703 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | phosphatidylcholine biosynthetic process |
| REAC:R-HSA-201681 | 0.0182953414124 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 0.0190389564297 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | PIP3 activates AKT signaling |
| GO:0005956 | 0.0283955176165 | 0.285714285714 | CSNK2A1 CSNK2B | protein kinase CK2 complex |
| REAC:R-HSA-9006925 | 0.0302306691506 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Intracellular signaling by second messengers |
| REAC:R-HSA-195721 | 0.0491203268289 | 0.428571428571 | CSNK2A2 CSNK2B CSNK2A1 | Signaling by WNT |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK2A1 | CSNK2B | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CSNK2A2 | CSNK2A1 | 1.0 | 0.949 | hein_WMM bioplex (CSNK2A2) bioplex_WMM boldt youn_WMM hein (CSNK2A2) Malo gupta_WMM fraction boldt_WMM |
| CSNK2A2 | CSNK2B | 0.994 | 0.923 | hein_WMM bioplex_WMM boldt youn_WMM hein (CSNK2A2) gupta_WMM boldt_WMM |
| CSNK2A2 | NKAPD1 | 0.775 | 0.752 | bioplex (CSNK2A2,NKAPD1) bioplex_WMM |
| CSNK2A2 | VSX1 | 0.57 | 0.656 | bioplex (VSX1) bioplex_WMM |
| NKAPD1 | CSNK2A1 | 0.557 | 0.648 | bioplex (NKAPD1) bioplex_WMM |
| VSX1 | CSNK2A1 | 0.474 | 0.609 | bioplex (VSX1) bioplex_WMM |
| CSNK2A2 | NKAP | 0.473 | 0.608 | bioplex (CSNK2A2,NKAP) bioplex_WMM youn_WMM |
| CSNK2A2 | PCGF5 | 0.168 | 0.425 | bioplex (CSNK2A2,PCGF5) bioplex_WMM boldt youn_WMM boldt_WMM |
| NKAPD1 | CSNK2B | 0.142 | 0.406 | bioplex (NKAPD1) bioplex_WMM |
| CSNK2A1 | NKAP | 0.107 | 0.372 | bioplex (NKAP) bioplex_WMM boldt youn_WMM boldt_WMM |
| VSX1 | CSNK2B | 0.082 | 0.351 | bioplex (VSX1) bioplex_WMM |
| PCGF5 | CSNK2A1 | 0.078 | 0.352 | bioplex (PCGF5) bioplex_WMM boldt youn_WMM boldt_WMM |
| CSNK2B | NKAP | 0.024 | 0.214 | bioplex (NKAP) bioplex_WMM boldt youn_WMM boldt_WMM |
| PCGF5 | CSNK2B | 0.023 | 0.208 | bioplex (PCGF5) bioplex_WMM boldt youn_WMM boldt_WMM |
| PCGF5 | NKAPD1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| PCGF5 | NKAP | 0.007 | 0.006 | bioplex_WMM WMM_only |
| NKAPD1 | NKAP | 0.007 | 0.006 | bioplex (NKAPD1) bioplex_WMM |
Images
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Complex HuMAP2_05042 has an average edge precision of 0.471 which is ranked 2694 out of all 6965 complexes.
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