hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05043
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UQCR10 | Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) | UniProt NCBI |
| TMED3 | Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) | UniProt NCBI |
| SLC25A11 | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11) | UniProt NCBI |
| NDUFS1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-75kD) (CI-75kD) | UniProt NCBI |
| CYC1 | Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1) | UniProt NCBI |
| UQCRH | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00190 | 2.56835422091e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Oxidative phosphorylation |
| KEGG:05012 | 3.34705576874e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Parkinson disease |
| REAC:R-HSA-611105 | 3.62344030062e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Respiratory electron transport |
| KEGG:04932 | 4.16262235351e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP4396 | 4.18673313073e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Nonalcoholic fatty liver disease |
| KEGG:05010 | 7.51229021242e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Alzheimer disease |
| REAC:R-HSA-163200 | 8.48766333534e-06 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 1.28484416656e-05 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Huntington disease |
| KEGG:04714 | 2.55974342297e-05 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Thermogenesis |
| REAC:R-HSA-1428517 | 3.51056084595e-05 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:04260 | 0.000116933248876 | 0.5 | UQCRH CYC1 UQCR10 | Cardiac muscle contraction |
| WP:WP111 | 0.000192159737634 | 0.5 | NDUFS1 UQCR10 UQCRH | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0098803 | 0.000295964852823 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | respiratory chain complex |
| GO:0045275 | 0.000299339163023 | 0.5 | UQCRH CYC1 UQCR10 | respiratory chain complex III |
| GO:0006122 | 0.000299339163023 | 0.5 | UQCRH CYC1 UQCR10 | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0005750 | 0.000299339163023 | 0.5 | UQCRH CYC1 UQCR10 | mitochondrial respiratory chain complex III |
| GO:0005746 | 0.000314144203038 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial respirasome |
| GO:0070469 | 0.000395345440439 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | respirasome |
| GO:0042775 | 0.000517834485544 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.000545393489246 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | ATP synthesis coupled electron transport |
| GO:0009055 | 0.000545393489246 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | electron transfer activity |
| GO:1990204 | 0.00084563217517 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | oxidoreductase complex |
| GO:0022904 | 0.000968898210955 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | respiratory electron transport chain |
| GO:0022900 | 0.00101282970404 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | electron transport chain |
| GO:0005743 | 0.00232803219041 | 0.833333333333 | SLC25A11 NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial inner membrane |
| GO:0098800 | 0.0024130539346 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | inner mitochondrial membrane protein complex |
| GO:0006119 | 0.0028699930952 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | oxidative phosphorylation |
| GO:0070069 | 0.0032070828615 | 0.5 | UQCRH CYC1 UQCR10 | cytochrome complex |
| GO:0019866 | 0.00343452854206 | 0.833333333333 | SLC25A11 NDUFS1 UQCR10 CYC1 UQCRH | organelle inner membrane |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | cellular respiration |
| GO:0031966 | 0.0109160303478 | 0.833333333333 | SLC25A11 NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial membrane |
| GO:0044455 | 0.0148506630994 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial membrane part |
| GO:0005740 | 0.0151221141199 | 0.833333333333 | SLC25A11 NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial envelope |
| GO:0015980 | 0.023174580771 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | energy derivation by oxidation of organic compounds |
| REAC:R-HSA-1430728 | 0.0278608311428 | 0.833333333333 | SLC25A11 NDUFS1 UQCR10 CYC1 UQCRH | Metabolism |
| KEGG:01100 | 0.0331288091988 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | Metabolic pathways |
| GO:0098798 | 0.0434575095048 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | mitochondrial protein complex |
| GO:0046034 | 0.0457293961323 | 0.666666666667 | NDUFS1 UQCR10 CYC1 UQCRH | ATP metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CYC1 | UQCRH | 0.937 | 0.85 | bioplex (CYC1,UQCRH) bioplex_WMM boldt fraction boldt_WMM |
| CYC1 | UQCR10 | 0.266 | 0.482 | bioplex (CYC1) bioplex_WMM boldt boldt_WMM |
| UQCRH | UQCR10 | 0.048 | 0.296 | bioplex (UQCRH) bioplex_WMM boldt boldt_WMM |
| NDUFS1 | SLC25A11 | 0.04 | 0.268 | bioplex (NDUFS1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFS1 | UQCRH | 0.035 | 0.263 | boldt fraction boldt_WMM |
| TMED3 | CYC1 | 0.032 | 0.245 | bioplex (TMED3) bioplex_WMM fraction |
| NDUFS1 | CYC1 | 0.007 | 0.004 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TMED3 | NDUFS1 | 0.007 | 0.004 | hein_WMM WMM_only |
| NDUFS1 | UQCR10 | 0.007 | 0.003 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TMED3 | SLC25A11 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| SLC25A11 | UQCRH | 0.007 | 0.004 | bioplex (UQCRH) bioplex_WMM boldt boldt_WMM |
| SLC25A11 | CYC1 | 0.006 | 0.009 | bioplex_WMM boldt boldt_WMM |
| SLC25A11 | UQCR10 | 0.006 | 0.007 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TMED3 | UQCR10 | 0.005 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05043 has an average edge precision of 0.175 which is ranked 6475 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UQCR10 | HuMAP2_04147 HuMAP2_05043 |
| TMED3 | HuMAP2_00162 HuMAP2_02885 HuMAP2_05043 |
| SLC25A11 | HuMAP2_01874 HuMAP2_03418 HuMAP2_04140 HuMAP2_05031 HuMAP2_05043 |
| NDUFS1 | HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_02483 HuMAP2_03501 HuMAP2_05031 HuMAP2_05043 |
| CYC1 | HuMAP2_04006 HuMAP2_04147 HuMAP2_05043 |
| UQCRH | HuMAP2_04006 HuMAP2_04147 HuMAP2_05043 |