hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05045
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VIRMA | Protein virilizer homolog | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | UniProt NCBI |
| RBM15B | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | UniProt NCBI |
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 9.93317232561e-20 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 9.93317232561e-20 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | mRNA editing complex |
| GO:0080009 | 2.77322462653e-13 | 0.75 | METTL3 VIRMA CBLL1 METTL14 WTAP ZC3H13 | mRNA methylation |
| GO:0016556 | 2.50415573067e-12 | 0.75 | METTL3 VIRMA CBLL1 METTL14 WTAP ZC3H13 | mRNA modification |
| GO:0001510 | 7.6879197986e-12 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | RNA methylation |
| GO:0034708 | 3.21887327841e-10 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | methyltransferase complex |
| GO:0009451 | 1.10173021362e-09 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | RNA modification |
| GO:0043414 | 3.57867747938e-08 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | macromolecule methylation |
| GO:0032259 | 6.06564742e-08 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | methylation |
| CORUM:929 | 3.62776142917e-05 | 0.375 | WTAP VIRMA ZC3H13 | CEN complex |
| GO:0016607 | 7.16074966884e-05 | 0.75 | VIRMA CBLL1 RBM15B METTL3 WTAP ZC3H13 | nuclear speck |
| GO:1990234 | 0.000186987138222 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | transferase complex |
| GO:0016071 | 0.000214774794186 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | mRNA metabolic process |
| GO:0016604 | 0.00583833513213 | 0.75 | VIRMA CBLL1 RBM15B METTL3 WTAP ZC3H13 | nuclear body |
| GO:1903311 | 0.00673460397389 | 0.625 | WTAP RBM15B METTL3 VIRMA METTL14 | regulation of mRNA metabolic process |
| GO:1902494 | 0.00783585998931 | 0.875 | METTL3 VIRMA CBLL1 RBM15B METTL14 WTAP ZC3H13 | catalytic complex |
| GO:0006397 | 0.0348252240904 | 0.625 | WTAP RBM15B METTL3 VIRMA METTL14 | mRNA processing |
| REAC:R-HSA-72203 | 0.0363175855426 | 0.375 | METTL14 METTL3 WTAP | Processing of Capped Intron-Containing Pre-mRNA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VIRMA | CBLL2 | 1.0 | 0.949 | bioplex (CBLL2) bioplex_WMM |
| VIRMA | CBLL1 | 0.993 | 0.918 | youn (VIRMA) youn_WMM Malo fraction |
| VIRMA | ZC3H13 | 0.988 | 0.902 | bioplex_WMM Guru youn_WMM Malo fraction |
| CBLL1 | WTAP | 0.976 | 0.889 | youn_WMM Malo fraction |
| CBLL2 | ZC3H13 | 0.96 | 0.865 | bioplex (CBLL2) bioplex_WMM |
| ZC3H13 | WTAP | 0.954 | 0.861 | bioplex_WMM Guru youn_WMM Malo fraction |
| VIRMA | WTAP | 0.921 | 0.843 | hein_WMM youn (VIRMA) bioplex_WMM Guru youn_WMM Malo fraction |
| CBLL2 | WTAP | 0.627 | 0.68 | bioplex (CBLL2) bioplex_WMM |
| WTAP | METTL3 | 0.324 | 0.513 | hein_WMM bioplex_WMM youn_WMM hein (METTL3) |
| RBM15B | METTL3 | 0.084 | 0.347 | hein_WMM youn_WMM hein (METTL3) |
| METTL14 | METTL3 | 0.05 | 0.294 | hein_WMM youn_WMM hein (METTL3) Malo fraction |
| METTL14 | WTAP | 0.009 | 0.107 | hein_WMM youn_WMM WMM_only |
| RBM15B | ZC3H13 | 0.008 | 0.061 | hein_WMM bioplex_WMM WMM_only |
| VIRMA | RBM15B | 0.008 | 0.023 | bioplex_WMM youn_WMM WMM_only |
| CBLL1 | ZC3H13 | 0.008 | 0.023 | hein_WMM WMM_only |
| RBM15B | WTAP | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| RBM15B | METTL14 | 0.007 | 0.008 | hein_WMM WMM_only |
| CBLL1 | METTL3 | 0.007 | 0.005 | youn_WMM WMM_only |
| METTL14 | CBLL1 | 0.007 | 0.009 | youn_WMM WMM_only |
| RBM15B | CBLL1 | 0.007 | 0.002 | youn_WMM WMM_only |
| ZC3H13 | METTL3 | 0.007 | 0.001 | youn_WMM WMM_only |
| VIRMA | METTL3 | 0.006 | 0.002 | youn (VIRMA) youn_WMM |
| VIRMA | METTL14 | 0.005 | 0.009 | youn (VIRMA) youn_WMM |
Images
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Complex HuMAP2_05045 has an average edge precision of 0.362 which is ranked 3737 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VIRMA | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| CBLL1 | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| CBLL2 | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| RBM15B | HuMAP2_00310 HuMAP2_05045 HuMAP2_06148 |
| METTL14 | HuMAP2_00310 HuMAP2_05045 HuMAP2_06148 |
| ZC3H13 | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| WTAP | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| METTL3 | HuMAP2_00310 HuMAP2_05045 HuMAP2_06148 |