hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05064
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDC123 | Cell division cycle protein 123 homolog (Protein D123) (HT-1080) (PZ32) | UniProt NCBI |
| METAP2 | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | UniProt NCBI |
| PRMT7 | Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) | UniProt NCBI |
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX) | UniProt NCBI |
| EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) | UniProt NCBI |
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5183 | 1.26104188141e-07 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| REAC:R-HSA-72731 | 3.33245821776e-07 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Recycling of eIF2:GDP |
| GO:0005850 | 7.26438828159e-06 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | eukaryotic translation initiation factor 2 complex |
| REAC:R-HSA-381042 | 2.16753530756e-05 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | PERK regulates gene expression |
| WP:WP107 | 2.92137873708e-05 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Translation Factors |
| REAC:R-HSA-72695 | 0.000130640571844 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72649 | 0.000191968063148 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.000191968063148 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 0.000202041038028 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-381119 | 0.000540594236106 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Unfolded Protein Response (UPR) |
| REAC:R-HSA-382556 | 0.000920605178739 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | ABC-family proteins mediated transport |
| KEGG:03013 | 0.0009622006058 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | RNA transport |
| REAC:R-HSA-156827 | 0.00126461482378 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.00129954570423 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72737 | 0.00156211728615 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 0.00156211728615 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Eukaryotic Translation Initiation |
| GO:0006413 | 0.011511251229 | 0.666666666667 | CDC123 EIF2S1 EIF2S2 EIF2S3 | translational initiation |
| GO:0003743 | 0.0192515670318 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | translation initiation factor activity |
| GO:0022618 | 0.0213715329849 | 0.666666666667 | PRMT7 EIF2S1 EIF2S2 EIF2S3 | ribonucleoprotein complex assembly |
| REAC:R-HSA-72766 | 0.0229344817985 | 0.5 | EIF2S3 EIF2S1 EIF2S2 | Translation |
| GO:0071826 | 0.0281789689517 | 0.666666666667 | PRMT7 EIF2S1 EIF2S2 EIF2S3 | ribonucleoprotein complex subunit organization |
| MIRNA:hsa-miR-4777-3p | 0.0371299472089 | 0.333333333333 | EIF2S3 EIF2S1 | hsa-miR-4777-3p |
| MIRNA:hsa-miR-4474-3p | 0.0499802324417 | 0.333333333333 | EIF2S3 METAP2 | hsa-miR-4474-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF2S3 | EIF2S2 | 1.0 | 0.949 | hein_WMM bioplex (EIF2S2) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| EIF2S1 | EIF2S3 | 0.981 | 0.896 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| CDC123 | EIF2S2 | 0.884 | 0.816 | bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM |
| PRMT7 | EIF2S2 | 0.815 | 0.773 | bioplex (EIF2S2) bioplex_WMM youn_WMM |
| EIF2S1 | EIF2S2 | 0.511 | 0.63 | hein_WMM bioplex (EIF2S2) bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| EIF2S2 | METAP2 | 0.047 | 0.29 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S3 | METAP2 | 0.034 | 0.264 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| PRMT7 | EIF2S3 | 0.008 | 0.057 | bioplex_WMM youn_WMM WMM_only |
| EIF2S1 | PRMT7 | 0.008 | 0.041 | bioplex_WMM WMM_only |
| EIF2S1 | CDC123 | 0.007 | 0.009 | bioplex_WMM gupta_WMM WMM_only |
| PRMT7 | CDC123 | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| CDC123 | EIF2S3 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | METAP2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| EIF2S1 | METAP2 | 0.0 | 0.009 | bioplex_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_05064 has an average edge precision of 0.339 which is ranked 4138 out of all 6965 complexes.
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