hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05070
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FBXL5 | F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein) | UniProt NCBI |
| DBNL | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | UniProt NCBI |
| FGD6 | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | UniProt NCBI |
| RNF115 | E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rabring 7) (Zinc finger protein 364) | UniProt NCBI |
| NEURL4 | Neuralized-like protein 4 | UniProt NCBI |
| ZBTB5 | Zinc finger and BTB domain-containing protein 5 | UniProt NCBI |
| HERC2 | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6860 | 6.04024714829e-05 | 0.285714285714 | NEURL4 HERC2 | E6AP-HERC2-MAPK6-NEURL4 complex |
| REAC:R-HSA-983168 | 0.0411773376996 | 0.428571428571 | RNF115 FBXL5 HERC2 | Antigen processing: Ubiquitination & Proteasome degradation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HERC2 | NEURL4 | 0.859 | 0.796 | hein_WMM bioplex_WMM hein (HERC2) gupta_WMM boldt_WMM |
| NEURL4 | DBNL | 0.588 | 0.663 | bioplex (DBNL) bioplex_WMM gupta_WMM |
| HERC2 | DBNL | 0.245 | 0.469 | bioplex (DBNL) bioplex_WMM gupta_WMM |
| FGD6 | DBNL | 0.157 | 0.416 | bioplex (DBNL) bioplex_WMM boldt boldt_WMM |
| ZBTB5 | HERC2 | 0.044 | 0.277 | hein_WMM hein (HERC2) |
| NEURL4 | FBXL5 | 0.039 | 0.266 | bioplex (FBXL5) bioplex_WMM |
| HERC2 | FBXL5 | 0.039 | 0.263 | bioplex (FBXL5) bioplex_WMM |
| HERC2 | RNF115 | 0.024 | 0.214 | bioplex (HERC2) bioplex_WMM |
| ZBTB5 | NEURL4 | 0.008 | 0.06 | hein_WMM WMM_only |
| FGD6 | NEURL4 | 0.008 | 0.042 | bioplex_WMM WMM_only |
| FGD6 | HERC2 | 0.008 | 0.019 | bioplex_WMM WMM_only |
| ZBTB5 | DBNL | 0.007 | 0.0 | youn_WMM WMM_only |
Images
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Complex HuMAP2_05070 has an average edge precision of 0.29 which is ranked 4744 out of all 6965 complexes.
Related Complexes