hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05079
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BBS7 | Bardet-Biedl syndrome 7 protein (BBS2-like protein 1) | UniProt NCBI |
| ZNF655 | Zinc finger protein 655 (Vav-interacting Krueppel-like protein) | UniProt NCBI |
| BBS10 | Bardet-Biedl syndrome 10 protein | UniProt NCBI |
| PROS1 | Vitamin K-dependent protein S | UniProt NCBI |
| C4BPB | C4b-binding protein beta chain | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6247 | 0.000301566439547 | 0.4 | BBS7 BBS10 | BBS-chaperonin complex |
| REAC:R-HSA-5620922 | 0.00282729215335 | 0.4 | BBS7 BBS10 | BBSome-mediated cargo-targeting to cilium |
| KEGG:04610 | 0.00858395707223 | 0.4 | PROS1 C4BPB | Complement and coagulation cascades |
| REAC:R-HSA-977606 | 0.00944309181669 | 0.4 | PROS1 C4BPB | Regulation of Complement cascade |
| REAC:R-HSA-166658 | 0.0132857243802 | 0.4 | PROS1 C4BPB | Complement cascade |
| HP:0010747 | 0.0138999712057 | 0.4 | BBS7 BBS10 | Medial flaring of the eyebrow |
| REAC:R-HSA-5620920 | 0.0145030354259 | 0.4 | BBS7 BBS10 | Cargo trafficking to the periciliary membrane |
| WP:WP4536 | 0.0173052901509 | 0.4 | BBS7 BBS10 | Genes related to primary cilium development (based on CRISPR) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ZNF655 | C4BPB | 0.575 | 0.657 | bioplex (C4BPB) bioplex_WMM |
| C4BPB | PROS1 | 0.308 | 0.503 | bioplex (C4BPB) bioplex_WMM |
| BBS7 | BBS10 | 0.022 | 0.208 | bioplex (BBS7) bioplex_WMM |
| BBS7 | ZNF655 | 0.021 | 0.188 | bioplex (BBS7) bioplex_WMM |
| BBS10 | ZNF655 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ZNF655 | PROS1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| BBS7 | PROS1 | 0.006 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05079 has an average edge precision of 0.232 which is ranked 5666 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BBS7 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 HuMAP2_05079 |
| ZNF655 | HuMAP2_02299 HuMAP2_04992 HuMAP2_05079 |
| BBS10 | HuMAP2_01662 HuMAP2_04530 HuMAP2_05079 |
| PROS1 | HuMAP2_04992 HuMAP2_05079 |
| C4BPB | HuMAP2_02299 HuMAP2_04992 HuMAP2_05079 |