hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05080
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MEX3D | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | UniProt NCBI |
| PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | UniProt NCBI |
| PLK4 | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | UniProt NCBI |
| FOXA1 | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | UniProt NCBI |
| COL4A2 | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | UniProt NCBI |
| COL4A5 | Collagen alpha-5(IV) chain | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | UniProt NCBI |
| COL25A1 | Collagen alpha-1(XXV) chain (Alzheimer disease amyloid-associated protein) (AMY) (CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component (CLAC)] | UniProt NCBI |
| COL4A6 | Collagen alpha-6(IV) chain | UniProt NCBI |
| COL13A1 | Collagen alpha-1(XIII) chain (COLXIIIA1) | UniProt NCBI |
| ODF2 | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 1.09061841165e-12 | 0.636363636364 | COL4A6 COL25A1 COL4A2 COL4A1 PLOD1 COL13A1 COL4A5 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 9.99241038469e-12 | 0.636363636364 | COL4A6 COL25A1 COL4A2 COL4A1 PLOD1 COL13A1 COL4A5 | Collagen formation |
| REAC:R-HSA-8948216 | 2.16180343317e-11 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | Collagen chain trimerization |
| REAC:R-HSA-1442490 | 3.29717441625e-10 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | Collagen degradation |
| GO:0030020 | 2.94511633785e-09 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-1474228 | 3.50238824719e-08 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | Degradation of the extracellular matrix |
| REAC:R-HSA-1474244 | 3.74522380031e-08 | 0.636363636364 | COL4A6 COL25A1 COL4A2 COL4A1 PLOD1 COL13A1 COL4A5 | Extracellular matrix organization |
| REAC:R-HSA-2214320 | 4.79982255028e-08 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Anchoring fibril formation |
| KEGG:04974 | 5.74781570213e-08 | 0.454545454545 | COL4A2 COL4A6 COL4A5 COL13A1 COL4A1 | Protein digestion and absorption |
| REAC:R-HSA-2243919 | 1.07479001855e-07 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Crosslinking of collagen fibrils |
| GO:0098645 | 1.20667211847e-07 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | collagen network |
| GO:0005587 | 1.20667211847e-07 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | collagen type IV trimer |
| GO:0098642 | 1.20667211847e-07 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | network-forming collagen trimer |
| REAC:R-HSA-216083 | 2.79827869709e-07 | 0.454545454545 | COL4A2 COL4A6 COL4A5 COL13A1 COL4A1 | Integrin cell surface interactions |
| GO:0098651 | 2.81450928027e-07 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | basement membrane collagen trimer |
| GO:0005581 | 5.34825903109e-07 | 0.454545454545 | COL4A2 COL4A6 COL4A5 COL13A1 COL4A1 | collagen trimer |
| REAC:R-HSA-3000157 | 9.58230703722e-07 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Laminin interactions |
| GO:0005201 | 7.98544520358e-06 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | extracellular matrix structural constituent |
| KEGG:04512 | 1.00610640319e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | ECM-receptor interaction |
| REAC:R-HSA-2022090 | 1.27173111079e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-3000171 | 1.367195355e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Non-integrin membrane-ECM interactions |
| KEGG:05146 | 1.42438299385e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Amoebiasis |
| KEGG:04933 | 1.87590012779e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 1.96042814998e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Small cell lung cancer |
| GO:0098644 | 2.45052124229e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | complex of collagen trimers |
| REAC:R-HSA-3000178 | 2.48608168003e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | ECM proteoglycans |
| WP:WP4658 | 3.35118277567e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Small cell lung cancer |
| KEGG:04926 | 5.70285492806e-05 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Relaxin signaling pathway |
| WP:WP4239 | 0.000137207007708 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-419037 | 0.000322201710224 | 0.272727272727 | COL4A2 COL4A5 COL4A1 | NCAM1 interactions |
| KEGG:04510 | 0.00034828121118 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Focal adhesion |
| GO:0005788 | 0.000364148643399 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | endoplasmic reticulum lumen |
| GO:0030198 | 0.000487170902945 | 0.545454545455 | COL4A6 COL13A1 COL4A2 COL4A1 PLOD1 COL4A5 | extracellular matrix organization |
| GO:0005198 | 0.000510115903438 | 0.636363636364 | COL4A6 COL25A1 COL4A2 COL4A1 ODF2 COL13A1 COL4A5 | structural molecule activity |
| GO:0044420 | 0.000525134045179 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | extracellular matrix component |
| HP:0000482 | 0.000681009388091 | 0.363636363636 | PLOD1 PLK4 COL4A1 COL25A1 | Microcornea |
| GO:0043062 | 0.00117126367043 | 0.545454545455 | COL4A6 COL13A1 COL4A2 COL4A1 PLOD1 COL4A5 | extracellular structure organization |
| REAC:R-HSA-375165 | 0.00126400452333 | 0.272727272727 | COL4A2 COL4A5 COL4A1 | NCAM signaling for neurite out-growth |
| GO:0005604 | 0.00141287502504 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | basement membrane |
| GO:0062023 | 0.00143079629295 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | collagen-containing extracellular matrix |
| HP:0001120 | 0.00149111733377 | 0.363636363636 | PLOD1 PLK4 COL4A1 COL25A1 | Abnormality of corneal size |
| REAC:R-HSA-186797 | 0.0015970307267 | 0.272727272727 | COL4A2 COL4A5 COL4A1 | Signaling by PDGF |
| WP:WP3932 | 0.00173111929325 | 0.363636363636 | FOXA1 COL4A2 COL4A1 COL4A6 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| KEGG:04151 | 0.00214492340752 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.00249975553774 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Human papillomavirus infection |
| WP:WP4172 | 0.00270947302881 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | PI3K-Akt Signaling Pathway |
| GO:0031012 | 0.00426003298794 | 0.545454545455 | COL4A6 COL25A1 COL4A2 COL4A1 COL13A1 COL4A5 | extracellular matrix |
| WP:WP2911 | 0.00699227925321 | 0.181818181818 | COL4A2 COL4A1 | miRNA targets in ECM and membrane receptors |
| MIRNA:hsa-miR-29b-3p | 0.00741952151679 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | hsa-miR-29b-3p |
| KEGG:05200 | 0.0117077555386 | 0.363636363636 | COL4A2 COL4A6 COL4A5 COL4A1 | Pathways in cancer |
| REAC:R-HSA-3000480 | 0.0147010386662 | 0.181818181818 | COL4A2 COL4A1 | Scavenging by Class A Receptors |
| HP:0000481 | 0.0149283124775 | 0.454545454545 | COL25A1 PLOD1 PLK4 COL4A5 COL4A1 | Abnormal cornea morphology |
| WP:WP306 | 0.0205076768663 | 0.272727272727 | COL4A2 COL4A1 COL4A6 | Focal Adhesion |
| GO:0044432 | 0.0438007606432 | 0.636363636364 | COL4A6 COL25A1 COL4A2 COL4A1 PLOD1 COL13A1 COL4A5 | endoplasmic reticulum part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COL4A1 | PLOD1 | 0.854 | 0.793 | hein_WMM bioplex (PLOD1) bioplex_WMM |
| COL4A2 | PLOD1 | 0.602 | 0.671 | bioplex (PLOD1) bioplex_WMM boldt_WMM |
| PLOD1 | COL4A6 | 0.524 | 0.635 | bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL4A5 | 0.5 | 0.621 | bioplex (PLOD1) bioplex_WMM |
| FOXA1 | PLOD1 | 0.478 | 0.61 | bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL13A1 | 0.115 | 0.385 | bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL25A1 | 0.073 | 0.355 | bioplex (PLOD1) bioplex_WMM gupta_WMM |
| PLOD1 | MEX3D | 0.052 | 0.302 | bioplex (PLOD1) bioplex_WMM youn_WMM |
| PLOD1 | ODF2 | 0.05 | 0.298 | bioplex (PLOD1) bioplex_WMM gupta_WMM |
| PLOD1 | PLK4 | 0.034 | 0.264 | bioplex (PLK4,PLOD1) bioplex_WMM |
| COL4A1 | COL4A2 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| COL4A1 | COL4A5 | 0.011 | 0.148 | bioplex_WMM WMM_only |
| COL4A2 | COL4A6 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| COL4A1 | COL4A6 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| COL4A2 | COL4A5 | 0.01 | 0.122 | bioplex_WMM WMM_only |
| COL4A6 | COL4A5 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| COL13A1 | COL25A1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| FOXA1 | COL25A1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| COL25A1 | PLK4 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| COL13A1 | PLK4 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FOXA1 | COL13A1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| COL13A1 | COL4A5 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| COL25A1 | COL4A5 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| COL13A1 | COL4A6 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| COL25A1 | MEX3D | 0.008 | 0.085 | bioplex_WMM WMM_only |
| COL4A6 | COL25A1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| FOXA1 | PLK4 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| COL13A1 | MEX3D | 0.008 | 0.085 | bioplex_WMM WMM_only |
| COL4A1 | COL25A1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| COL4A1 | COL13A1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| COL25A1 | ODF2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| COL13A1 | ODF2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| COL4A5 | PLK4 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| FOXA1 | COL4A5 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| FOXA1 | MEX3D | 0.008 | 0.06 | bioplex_WMM WMM_only |
| COL4A6 | PLK4 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| FOXA1 | COL4A6 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PLK4 | MEX3D | 0.008 | 0.06 | bioplex_WMM WMM_only |
| COL4A1 | PLK4 | 0.008 | 0.047 | bioplex_WMM WMM_only |
| FOXA1 | COL4A1 | 0.008 | 0.047 | bioplex_WMM WMM_only |
| FOXA1 | ODF2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| PLK4 | ODF2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| COL4A5 | MEX3D | 0.008 | 0.04 | bioplex_WMM WMM_only |
| COL4A2 | COL25A1 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| COL4A2 | COL13A1 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| COL4A5 | ODF2 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| COL4A6 | MEX3D | 0.008 | 0.026 | bioplex_WMM WMM_only |
| COL4A1 | MEX3D | 0.008 | 0.027 | bioplex_WMM WMM_only |
| MEX3D | ODF2 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| COL4A6 | ODF2 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| COL4A1 | ODF2 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| FOXA1 | COL4A2 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| COL4A2 | PLK4 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| COL4A2 | MEX3D | 0.007 | 0.008 | bioplex_WMM WMM_only |
| COL4A2 | ODF2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05080 has an average edge precision of 0.145 which is ranked 6739 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MEX3D | HuMAP2_05080 HuMAP2_06931 |
| PLOD1 | HuMAP2_02722 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 |
| PLK4 | HuMAP2_05080 |
| FOXA1 | HuMAP2_01094 HuMAP2_05080 |
| COL4A2 | HuMAP2_02722 HuMAP2_04238 HuMAP2_05080 HuMAP2_06216 HuMAP2_06790 |
| COL4A5 | HuMAP2_04238 HuMAP2_05080 HuMAP2_05161 HuMAP2_05432 |
| COL4A1 | HuMAP2_01361 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 HuMAP2_05564 |
| COL25A1 | HuMAP2_02856 HuMAP2_05080 |
| COL4A6 | HuMAP2_02856 HuMAP2_04238 HuMAP2_05080 |
| COL13A1 | HuMAP2_02856 HuMAP2_05080 |
| ODF2 | HuMAP2_05080 |