hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05081
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GUCY1B1 | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) | UniProt NCBI |
| GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:408 | 1.67592346237e-06 | 1.0 | GUCY1B1 GUCY1A1 | Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) |
| KEGG:04730 | 0.000201046815819 | 1.0 | GUCY1B1 GUCY1A1 | Long-term depression |
| KEGG:04924 | 0.000201046815819 | 1.0 | GUCY1B1 GUCY1A1 | Renin secretion |
| REAC:R-HSA-392154 | 0.000256416289743 | 1.0 | GUCY1B1 GUCY1A1 | Nitric oxide stimulates guanylate cyclase |
| WP:WP4222 | 0.000320792526609 | 1.0 | GUCY1B1 GUCY1A1 | Phosphodiesterases in neuronal function |
| WP:WP4008 | 0.000336440942541 | 1.0 | GUCY1B1 GUCY1A1 | NO/cGMP/PKG mediated Neuroprotection |
| KEGG:04970 | 0.00039406926671 | 1.0 | GUCY1B1 GUCY1A1 | Salivary secretion |
| GO:0008074 | 0.000450823411379 | 1.0 | GUCY1B1 GUCY1A1 | guanylate cyclase complex, soluble |
| KEGG:04540 | 0.000508598838856 | 1.0 | GUCY1B1 GUCY1A1 | Gap junction |
| KEGG:04713 | 0.000558495798951 | 1.0 | GUCY1B1 GUCY1A1 | Circadian entrainment |
| KEGG:04270 | 0.000707748986601 | 1.0 | GUCY1B1 GUCY1A1 | Vascular smooth muscle contraction |
| REAC:R-HSA-445355 | 0.000884887588134 | 1.0 | GUCY1B1 GUCY1A1 | Smooth Muscle Contraction |
| KEGG:04611 | 0.000890704506947 | 1.0 | GUCY1B1 GUCY1A1 | Platelet activation |
| KEGG:00230 | 0.000890704506947 | 1.0 | GUCY1B1 GUCY1A1 | Purine metabolism |
| KEGG:04921 | 0.00131964328671 | 1.0 | GUCY1B1 GUCY1A1 | Oxytocin signaling pathway |
| KEGG:04022 | 0.00144000876062 | 1.0 | GUCY1B1 GUCY1A1 | cGMP-PKG signaling pathway |
| REAC:R-HSA-418346 | 0.00490375205091 | 1.0 | GUCY1B1 GUCY1A1 | Platelet homeostasis |
| GO:0006182 | 0.00946729163895 | 1.0 | GUCY1B1 GUCY1A1 | cGMP biosynthetic process |
| GO:0004383 | 0.00946729163895 | 1.0 | GUCY1B1 GUCY1A1 | guanylate cyclase activity |
| GO:0046068 | 0.0162296428096 | 1.0 | GUCY1B1 GUCY1A1 | cGMP metabolic process |
| REAC:R-HSA-397014 | 0.0246461304377 | 1.0 | GUCY1B1 GUCY1A1 | Muscle contraction |
| CORUM:407 | 0.0499173803268 | 0.5 | GUCY1B1 | Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GUCY1B1 | GUCY1A1 | 0.999 | 0.949 | bioplex (GUCY1B1) bioplex_WMM |
Images
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Complex HuMAP2_05081 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GUCY1B1 | HuMAP2_02077 HuMAP2_05001 HuMAP2_05081 |
| GUCY1A1 | HuMAP2_02077 HuMAP2_05001 HuMAP2_05081 |