hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05088
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPARGC1B | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | UniProt NCBI |
| CASP1 | Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] | UniProt NCBI |
| MTMR4 | Myotubularin-related protein 4 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Zinc finger FYVE domain-containing protein 11) | UniProt NCBI |
| DNAJC10 | DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) | UniProt NCBI |
| PLCL2 | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | UniProt NCBI |
| CASP12 | Inactive caspase-12 (CASP-12) | UniProt NCBI |
| PI4KB | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) | UniProt NCBI |
| RDM1 | RAD52 motif-containing protein 1 (RAD52 homolog B) | UniProt NCBI |
| LTBP4 | Latent-transforming growth factor beta-binding protein 4 (LTBP-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2447 | 0.0135106647521 | 0.222222222222 | CASP12 CASP1 | Amyotrophic lateral sclerosis (ALS) |
| KEGG:05014 | 0.0208570639682 | 0.222222222222 | CASP12 CASP1 | Amyotrophic lateral sclerosis (ALS) |
| KEGG:00562 | 0.0403966480843 | 0.222222222222 | PI4KB MTMR4 | Inositol phosphate metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASP12 | CASP1 | 0.566 | 0.654 | bioplex (CASP1) bioplex_WMM |
| CASP1 | PI4KB | 0.5 | 0.621 | bioplex (CASP1) bioplex_WMM |
| PI4KB | DNAJC10 | 0.117 | 0.391 | bioplex (DNAJC10) bioplex_WMM |
| DNAJC10 | PPARGC1B | 0.107 | 0.372 | bioplex (DNAJC10) bioplex_WMM |
| PI4KB | RDM1 | 0.072 | 0.353 | bioplex (RDM1) bioplex_WMM |
| DNAJC10 | MTMR4 | 0.037 | 0.265 | bioplex (DNAJC10) bioplex_WMM |
| CASP1 | PLCL2 | 0.025 | 0.211 | bioplex (CASP1) bioplex_WMM |
| DNAJC10 | LTBP4 | 0.023 | 0.211 | bioplex (DNAJC10) bioplex_WMM |
| CASP12 | PLCL2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CASP12 | PI4KB | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PI4KB | PLCL2 | 0.008 | 0.062 | bioplex_WMM WMM_only |
| PI4KB | PPARGC1B | 0.008 | 0.046 | bioplex_WMM WMM_only |
| PPARGC1B | MTMR4 | 0.007 | 0.011 | bioplex_WMM WMM_only |
| PPARGC1B | LTBP4 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PI4KB | MTMR4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| MTMR4 | LTBP4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PI4KB | LTBP4 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CASP1 | DNAJC10 | 0.007 | 0.003 | bioplex (CASP1) |
| RDM1 | DNAJC10 | 0.007 | 0.001 | bioplex (RDM1) |
Images
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Complex HuMAP2_05088 has an average edge precision of 0.178 which is ranked 6445 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPARGC1B | HuMAP2_02324 HuMAP2_05088 |
| CASP1 | HuMAP2_00389 HuMAP2_01283 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |
| MTMR4 | HuMAP2_02352 HuMAP2_03018 HuMAP2_05088 |
| DNAJC10 | HuMAP2_02324 HuMAP2_05088 |
| PLCL2 | HuMAP2_03028 HuMAP2_05088 HuMAP2_06738 |
| CASP12 | HuMAP2_00389 HuMAP2_01283 HuMAP2_03028 HuMAP2_05088 |
| PI4KB | HuMAP2_00389 HuMAP2_01283 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |
| RDM1 | HuMAP2_00389 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |
| LTBP4 | HuMAP2_05088 HuMAP2_05261 HuMAP2_05834 |