hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05094
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | UniProt NCBI |
| NOTCH1 | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | UniProt NCBI |
| MAML1 | Mastermind-like protein 1 (Mam-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3113 | 2.25356268047e-10 | 1.0 | RBPJ NOTCH1 MAML1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 2.25356268047e-10 | 1.0 | RBPJ NOTCH1 MAML1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 2.25356268047e-10 | 1.0 | RBPJ NOTCH1 MAML1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2639 | 6.44518926616e-08 | 1.0 | RBPJ NOTCH1 MAML1 | HES1 promoter-Notch enhancer complex |
| GO:0002193 | 9.08185760231e-08 | 1.0 | RBPJ NOTCH1 MAML1 | MAML1-RBP-Jkappa- ICN1 complex |
| REAC:R-HSA-8941856 | 1.28584716548e-07 | 1.0 | RBPJ NOTCH1 MAML1 | RUNX3 regulates NOTCH signaling |
| WP:WP3845 | 1.30366523313e-07 | 1.0 | RBPJ NOTCH1 MAML1 | Canonical and Non-canonical Notch signaling |
| REAC:R-HSA-210744 | 1.63653275606e-07 | 1.0 | RBPJ NOTCH1 MAML1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-9013695 | 4.35659406764e-07 | 1.0 | RBPJ NOTCH1 MAML1 | NOTCH4 Intracellular Domain Regulates Transcription |
| KEGG:04330 | 4.87623579541e-07 | 1.0 | RBPJ NOTCH1 MAML1 | Notch signaling pathway |
| WP:WP268 | 5.88646075373e-07 | 1.0 | RBPJ NOTCH1 MAML1 | Notch Signaling |
| REAC:R-HSA-9013508 | 7.96236129391e-07 | 1.0 | RBPJ NOTCH1 MAML1 | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-350054 | 1.31507096469e-06 | 1.0 | RBPJ NOTCH1 MAML1 | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 1.64282711281e-06 | 1.0 | RBPJ NOTCH1 MAML1 | Regulation of beta-cell development |
| KEGG:04658 | 1.7187866598e-06 | 1.0 | RBPJ NOTCH1 MAML1 | Th1 and Th2 cell differentiation |
| WP:WP61 | 1.78545455841e-06 | 1.0 | RBPJ NOTCH1 MAML1 | Notch Signaling Pathway |
| CORUM:2907 | 3.35600554376e-06 | 0.666666666667 | RBPJ NOTCH1 | RBP-Jkappa-Notch1 complex |
| REAC:R-HSA-2122947 | 5.54847547872e-06 | 1.0 | RBPJ NOTCH1 MAML1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9012852 | 5.95446148936e-06 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH3 |
| CORUM:2946 | 1.00675659188e-05 | 0.666666666667 | RBPJ NOTCH1 | YY1-Notch1-RBP-Jkappa complex |
| REAC:R-HSA-2644602 | 1.05322572372e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 1.05322572372e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2894862 | 1.05322572372e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644606 | 1.05322572372e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894858 | 1.05322572372e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-1980143 | 1.87320057001e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH1 |
| WP:WP4147 | 3.45203339774e-05 | 0.666666666667 | RBPJ NOTCH1 | PTF1A related regulatory pathway |
| REAC:R-HSA-9013694 | 3.55536741254e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH4 |
| REAC:R-HSA-1912408 | 5.46192807335e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8878159 | 5.64603800841e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Transcriptional regulation by RUNX3 |
| GO:0007221 | 6.17566316957e-05 | 1.0 | RBPJ NOTCH1 MAML1 | positive regulation of transcription of Notch receptor target |
| REAC:R-HSA-1912422 | 8.92382428809e-05 | 1.0 | RBPJ NOTCH1 MAML1 | Pre-NOTCH Expression and Processing |
| KEGG:05165 | 0.000150762444884 | 1.0 | RBPJ NOTCH1 MAML1 | Human papillomavirus infection |
| REAC:R-HSA-2197563 | 0.000240958766872 | 0.666666666667 | RBPJ MAML1 | NOTCH2 intracellular domain regulates transcription |
| GO:0045747 | 0.000450460137075 | 1.0 | RBPJ NOTCH1 MAML1 | positive regulation of Notch signaling pathway |
| REAC:R-HSA-157118 | 0.000787037376592 | 1.0 | RBPJ NOTCH1 MAML1 | Signaling by NOTCH |
| HP:0004050 | 0.000927625684184 | 0.666666666667 | RBPJ NOTCH1 | Absent hand |
| HP:0004935 | 0.000927625684184 | 0.666666666667 | RBPJ NOTCH1 | Pulmonary artery atresia |
| HP:0002040 | 0.00120138848745 | 0.666666666667 | RBPJ NOTCH1 | Esophageal varix |
| HP:0006970 | 0.00135150150266 | 0.666666666667 | RBPJ NOTCH1 | Periventricular leukomalacia |
| HP:0001362 | 0.00135150150266 | 0.666666666667 | RBPJ NOTCH1 | Calvarial skull defect |
| WP:WP2840 | 0.00175069745203 | 0.666666666667 | RBPJ NOTCH1 | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) |
| REAC:R-HSA-1980145 | 0.00252791438215 | 0.666666666667 | RBPJ MAML1 | Signaling by NOTCH2 |
| HP:0002132 | 0.00264917192674 | 0.666666666667 | RBPJ NOTCH1 | Porencephalic cyst |
| WP:WP2064 | 0.00272466033723 | 0.666666666667 | RBPJ NOTCH1 | Neural Crest Differentiation |
| REAC:R-HSA-5663202 | 0.00284240562301 | 1.0 | RBPJ NOTCH1 MAML1 | Diseases of signal transduction |
| GO:0008593 | 0.00396695540069 | 1.0 | RBPJ NOTCH1 MAML1 | regulation of Notch signaling pathway |
| HP:0001804 | 0.00410511241748 | 0.666666666667 | RBPJ NOTCH1 | Hypoplastic fingernail |
| HP:0001817 | 0.00410511241748 | 0.666666666667 | RBPJ NOTCH1 | Absent fingernail |
| HP:0001057 | 0.00437859029972 | 0.666666666667 | RBPJ NOTCH1 | Aplasia cutis congenita |
| GO:0035051 | 0.00497140885151 | 1.0 | RBPJ NOTCH1 MAML1 | cardiocyte differentiation |
| HP:0001409 | 0.0068832170429 | 0.666666666667 | RBPJ NOTCH1 | Portal hypertension |
| HP:0006707 | 0.00759733122278 | 0.666666666667 | RBPJ NOTCH1 | Abnormality of the hepatic vasculature |
| HP:0002612 | 0.00759733122278 | 0.666666666667 | RBPJ NOTCH1 | Congenital hepatic fibrosis |
| GO:0003205 | 0.00804289309261 | 1.0 | RBPJ NOTCH1 MAML1 | cardiac chamber development |
| WP:WP4239 | 0.00862429622552 | 0.666666666667 | RBPJ NOTCH1 | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0100026 | 0.00873443203011 | 0.666666666667 | RBPJ NOTCH1 | Arteriovenous malformation |
| HP:0001171 | 0.00913104209388 | 0.666666666667 | RBPJ NOTCH1 | Split hand |
| HP:0001641 | 0.00953643840968 | 0.666666666667 | RBPJ NOTCH1 | Abnormal pulmonary valve morphology |
| HP:0100257 | 0.00995061979035 | 0.666666666667 | RBPJ NOTCH1 | Ectrodactyly |
| HP:0001798 | 0.0121532611158 | 0.666666666667 | RBPJ NOTCH1 | Anonychia |
| GO:0007219 | 0.0121736852044 | 1.0 | RBPJ NOTCH1 MAML1 | Notch signaling pathway |
| GO:0048738 | 0.0129761581422 | 1.0 | RBPJ NOTCH1 MAML1 | cardiac muscle tissue development |
| GO:0061419 | 0.0135228859698 | 0.666666666667 | RBPJ NOTCH1 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| GO:0003160 | 0.0135228859698 | 0.666666666667 | RBPJ NOTCH1 | endocardium morphogenesis |
| GO:0003256 | 0.0135228859698 | 0.666666666667 | RBPJ NOTCH1 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| HP:0010760 | 0.0135801907106 | 0.666666666667 | RBPJ NOTCH1 | Absent toe |
| HP:0000965 | 0.0156055992881 | 0.666666666667 | RBPJ NOTCH1 | Cutis marmorata |
| HP:0002518 | 0.0161338784795 | 0.666666666667 | RBPJ NOTCH1 | Abnormality of the periventricular white matter |
| HP:0001269 | 0.017771321972 | 0.666666666667 | RBPJ NOTCH1 | Hemiparesis |
| GO:0060837 | 0.020283420769 | 0.666666666667 | RBPJ NOTCH1 | blood vessel endothelial cell differentiation |
| HP:0030966 | 0.0218987389569 | 0.666666666667 | RBPJ NOTCH1 | Abnormal pulmonary artery morphology |
| HP:0010624 | 0.0218987389569 | 0.666666666667 | RBPJ NOTCH1 | Aplastic/hypoplastic toenail |
| HP:0001541 | 0.0218987389569 | 0.666666666667 | RBPJ NOTCH1 | Ascites |
| HP:0004414 | 0.0278358341925 | 0.666666666667 | RBPJ NOTCH1 | Abnormality of the pulmonary artery |
| GO:0003222 | 0.0283955176165 | 0.666666666667 | RBPJ NOTCH1 | ventricular trabecula myocardium morphogenesis |
| HP:0011815 | 0.0314403819239 | 0.666666666667 | RBPJ NOTCH1 | Cephalocele |
| HP:0002084 | 0.0314403819239 | 0.666666666667 | RBPJ NOTCH1 | Encephalocele |
| HP:0004890 | 0.0352634284647 | 0.666666666667 | RBPJ NOTCH1 | Elevated pulmonary artery pressure |
| HP:0002092 | 0.0352634284647 | 0.666666666667 | RBPJ NOTCH1 | Pulmonary arterial hypertension |
| GO:0060379 | 0.0378589948753 | 0.666666666667 | RBPJ NOTCH1 | cardiac muscle cell myoblast differentiation |
| HP:0001792 | 0.0384790851177 | 0.666666666667 | RBPJ NOTCH1 | Small nail |
| HP:0001991 | 0.0401392937999 | 0.666666666667 | RBPJ NOTCH1 | Aplasia/Hypoplasia of toe |
| HP:0001395 | 0.0426950555564 | 0.666666666667 | RBPJ NOTCH1 | Hepatic fibrosis |
| HP:0004930 | 0.044442515366 | 0.666666666667 | RBPJ NOTCH1 | Abnormality of the pulmonary vasculature |
| GO:0014706 | 0.047104416733 | 1.0 | RBPJ NOTCH1 MAML1 | striated muscle tissue development |
| GO:2000136 | 0.0486736709081 | 0.666666666667 | RBPJ NOTCH1 | regulation of cell proliferation involved in heart morphogenesis |
| HP:0008388 | 0.0498941597886 | 0.666666666667 | RBPJ NOTCH1 | Abnormal toenail morphology |
| CORUM:2947 | 0.0499776345577 | 0.333333333333 | NOTCH1 | YY1-Notch1 complex |
| CORUM:2908 | 0.0499776345577 | 0.333333333333 | RBPJ | RBP-Jkappa-SHARP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 1.0 | 0.949 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| RBPJ | NOTCH1 | 0.863 | 0.799 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| MAML1 | NOTCH1 | 0.01 | 0.136 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05094 has an average edge precision of 0.628 which is ranked 1791 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RBPJ | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| NOTCH1 | HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| MAML1 | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |