hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05101
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WNT3 | Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog) | UniProt NCBI |
| WNT3A | Protein Wnt-3a | UniProt NCBI |
| PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | UniProt NCBI |
| PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4641262 | 5.47542005033e-06 | 0.75 | WNT3A PPP2R5A PPP2R5B | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-4791275 | 5.47542005033e-06 | 0.75 | WNT3A PPP2R5A PPP2R5B | Signaling by WNT in cancer |
| KEGG:05165 | 6.99843546146e-06 | 1.0 | WNT3A PPP2R5B WNT3 PPP2R5A | Human papillomavirus infection |
| REAC:R-HSA-201681 | 8.93221849381e-06 | 1.0 | WNT3A PPP2R5B WNT3 PPP2R5A | TCF dependent signaling in response to WNT |
| REAC:R-HSA-195721 | 3.42260325769e-05 | 1.0 | WNT3A PPP2R5B WNT3 PPP2R5A | Signaling by WNT |
| REAC:R-HSA-4839744 | 0.000914071346391 | 0.5 | PPP2R5B PPP2R5A | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-4839735 | 0.000914071346391 | 0.5 | PPP2R5B PPP2R5A | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5467340 | 0.000914071346391 | 0.5 | PPP2R5B PPP2R5A | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-5467348 | 0.000914071346391 | 0.5 | PPP2R5B PPP2R5A | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-5467337 | 0.000914071346391 | 0.5 | PPP2R5B PPP2R5A | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-4839748 | 0.000914071346391 | 0.5 | PPP2R5B PPP2R5A | AMER1 mutants destabilize the destruction complex |
| WP:WP4150 | 0.000939830639711 | 0.5 | WNT3A WNT3 | Wnt Signaling in Kidney Disease |
| REAC:R-HSA-5358747 | 0.00105460323216 | 0.5 | PPP2R5B PPP2R5A | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358751 | 0.00105460323216 | 0.5 | PPP2R5B PPP2R5A | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358749 | 0.00105460323216 | 0.5 | PPP2R5B PPP2R5A | S37 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358752 | 0.00105460323216 | 0.5 | PPP2R5B PPP2R5A | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-4839743 | 0.00105460323216 | 0.5 | PPP2R5B PPP2R5A | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-5339716 | 0.00105460323216 | 0.5 | PPP2R5B PPP2R5A | Misspliced GSK3beta mutants stabilize beta-catenin |
| WP:WP500 | 0.00117729775616 | 0.5 | PPP2R5B PPP2R5A | Glycogen Synthesis and Degradation |
| REAC:R-HSA-432142 | 0.00136571756437 | 0.5 | PPP2R5B PPP2R5A | Platelet sensitization by LDL |
| REAC:R-HSA-196299 | 0.00136571756437 | 0.5 | PPP2R5B PPP2R5A | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-389513 | 0.00136571756437 | 0.5 | PPP2R5B PPP2R5A | CTLA4 inhibitory signaling |
| REAC:R-HSA-3238698 | 0.00253927088831 | 0.5 | WNT3A WNT3 | WNT ligand biogenesis and trafficking |
| KEGG:05217 | 0.00307073724034 | 0.5 | WNT3A WNT3 | Basal cell carcinoma |
| REAC:R-HSA-5673000 | 0.00407268683926 | 0.5 | PPP2R5B PPP2R5A | RAF activation |
| WP:WP4336 | 0.00501103584449 | 0.5 | WNT3A WNT3 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 0.00623747495525 | 0.5 | WNT3A WNT3 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-5675221 | 0.00667602194349 | 0.5 | PPP2R5B PPP2R5A | Negative regulation of MAPK pathway |
| KEGG:03015 | 0.00761107721317 | 0.5 | PPP2R5B PPP2R5A | mRNA surveillance pathway |
| WP:WP399 | 0.00775610812027 | 0.5 | WNT3A WNT3 | Wnt Signaling Pathway and Pluripotency |
| KEGG:04916 | 0.00778534503861 | 0.5 | WNT3A WNT3 | Melanogenesis |
| WP:WP3931 | 0.00791698216111 | 0.5 | WNT3A WNT3 | ESC Pluripotency Pathways |
| REAC:R-HSA-5663202 | 0.00839415877685 | 0.75 | WNT3A PPP2R5A PPP2R5B | Diseases of signal transduction |
| WP:WP710 | 0.00891657780243 | 0.5 | WNT3A WNT3 | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 0.00943843856088 | 0.5 | WNT3A WNT3 | Wnt Signaling |
| KEGG:04114 | 0.0112562119133 | 0.5 | PPP2R5B PPP2R5A | Oocyte meiosis |
| KEGG:04071 | 0.0116808588864 | 0.5 | PPP2R5B PPP2R5A | Sphingolipid signaling pathway |
| KEGG:04152 | 0.0123324218825 | 0.5 | PPP2R5B PPP2R5A | AMPK signaling pathway |
| WP:WP2857 | 0.0137135792553 | 0.5 | WNT3A WNT3 | Mesodermal Commitment Pathway |
| REAC:R-HSA-388841 | 0.0143225711665 | 0.5 | PPP2R5B PPP2R5A | Costimulation by the CD28 family |
| KEGG:04728 | 0.014392043024 | 0.5 | PPP2R5B PPP2R5A | Dopaminergic synapse |
| KEGG:04550 | 0.0148710843718 | 0.5 | WNT3A WNT3 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP4239 | 0.015016032698 | 0.5 | WNT3A WNT3 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 0.0159167413674 | 0.5 | WNT3A WNT3 | Breast cancer pathway |
| KEGG:04261 | 0.0163547130378 | 0.5 | PPP2R5B PPP2R5A | Adrenergic signaling in cardiomyocytes |
| KEGG:05224 | 0.016608760826 | 0.5 | WNT3A WNT3 | Breast cancer |
| KEGG:05226 | 0.0168647432957 | 0.5 | WNT3A WNT3 | Gastric cancer |
| REAC:R-HSA-373080 | 0.0189130304237 | 0.5 | WNT3A WNT3 | Class B/2 (Secretin family receptors) |
| KEGG:04934 | 0.0195308586359 | 0.5 | WNT3A WNT3 | Cushing syndrome |
| KEGG:04390 | 0.0198080875546 | 0.5 | WNT3A WNT3 | Hippo signaling pathway |
| KEGG:04150 | 0.0203683297936 | 0.5 | WNT3A WNT3 | mTOR signaling pathway |
| KEGG:04310 | 0.0212231461989 | 0.5 | WNT3A WNT3 | Wnt signaling pathway |
| REAC:R-HSA-6811558 | 0.0234490216385 | 0.5 | PPP2R5B PPP2R5A | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| KEGG:05206 | 0.0241976216174 | 0.5 | WNT3A WNT3 | MicroRNAs in cancer |
| KEGG:05225 | 0.0248155779574 | 0.5 | WNT3A WNT3 | Hepatocellular carcinoma |
| REAC:R-HSA-199418 | 0.0284687652941 | 0.5 | PPP2R5B PPP2R5A | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-418346 | 0.0292253078855 | 0.5 | PPP2R5B PPP2R5A | Platelet homeostasis |
| REAC:R-HSA-195253 | 0.0331557329305 | 0.5 | PPP2R5B PPP2R5A | Degradation of beta-catenin by the destruction complex |
| KEGG:05205 | 0.03463652866 | 0.5 | WNT3A WNT3 | Proteoglycans in cancer |
| REAC:R-HSA-141424 | 0.041754071825 | 0.5 | PPP2R5B PPP2R5A | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.041754071825 | 0.5 | PPP2R5B PPP2R5A | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WNT3A | WNT3 | 1.0 | 0.949 | bioplex (WNT3A) bioplex_WMM |
| WNT3A | PPP2R5A | 0.831 | 0.778 | bioplex (WNT3A) bioplex_WMM |
| WNT3A | PPP2R5B | 0.54 | 0.641 | bioplex (WNT3A) bioplex_WMM |
| PPP2R5A | PPP2R5B | 0.011 | 0.147 | bioplex_WMM WMM_only |
| PPP2R5B | WNT3 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| PPP2R5A | WNT3 | 0.009 | 0.098 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05101 has an average edge precision of 0.453 which is ranked 2855 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WNT3 | HuMAP2_01267 HuMAP2_01788 HuMAP2_04233 HuMAP2_05101 HuMAP2_06317 |
| WNT3A | HuMAP2_01267 HuMAP2_01788 HuMAP2_04233 HuMAP2_05101 HuMAP2_06317 |
| PPP2R5A | HuMAP2_01267 HuMAP2_01788 HuMAP2_04233 HuMAP2_05101 HuMAP2_06317 |
| PPP2R5B | HuMAP2_01267 HuMAP2_01788 HuMAP2_05101 HuMAP2_06317 |