hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05105
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GPS1 | COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) | UniProt NCBI |
| COPS5 | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | UniProt NCBI |
| COPS2 | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | UniProt NCBI |
| COPS6 | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | UniProt NCBI |
| COPS7A | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | UniProt NCBI |
| COPS3 | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) | UniProt NCBI |
| COPS7B | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) | UniProt NCBI |
| COPS8 | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | UniProt NCBI |
| CUL4B | Cullin-4B (CUL-4B) | UniProt NCBI |
| COPS4 | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000338 | 5.04260042897e-26 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | protein deneddylation |
| CORUM:2174 | 5.5854679245e-26 | 0.8 | COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | COP9 signalosome complex |
| GO:0000715 | 3.87599364582e-25 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | nucleotide-excision repair, DNA damage recognition |
| CORUM:2179 | 5.02632078618e-25 | 0.8 | COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | CNS-P53 complex |
| REAC:R-HSA-5696394 | 6.70117085375e-25 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | DNA Damage Recognition in GG-NER |
| CORUM:727 | 2.76348598149e-23 | 0.8 | COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | CSA complex |
| CORUM:726 | 2.76348598149e-23 | 0.8 | COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | DDB2 complex |
| REAC:R-HSA-6781823 | 2.7640674352e-23 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Formation of TC-NER Pre-Incision Complex |
| CORUM:728 | 7.18420526491e-23 | 0.8 | COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | CSA-POLIIa complex |
| REAC:R-HSA-6781827 | 1.78370809258e-21 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 3.91385340474e-21 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 6.6479085038e-20 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Nucleotide Excision Repair |
| GO:0008180 | 1.94208004876e-19 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | COP9 signalosome |
| GO:0006283 | 2.10499351371e-19 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | transcription-coupled nucleotide-excision repair |
| GO:0006289 | 9.77360066824e-18 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | nucleotide-excision repair |
| REAC:R-HSA-8856825 | 1.33468759589e-17 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8951664 | 9.24666028969e-17 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Neddylation |
| REAC:R-HSA-8856828 | 4.29252935029e-16 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | Clathrin-mediated endocytosis |
| REAC:R-HSA-73894 | 3.93848626657e-15 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | DNA Repair |
| GO:0043687 | 1.24597628464e-12 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | post-translational protein modification |
| WP:WP4352 | 4.04826837466e-12 | 0.8 | COPS7B COPS5 COPS4 COPS6 COPS8 COPS2 COPS3 COPS7A | Ciliary landscape |
| GO:0006281 | 3.21387234938e-11 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | DNA repair |
| GO:0070646 | 6.6903743629e-11 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | protein modification by small protein removal |
| REAC:R-HSA-199991 | 3.97902840722e-10 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 6.45480454488e-10 | 0.9 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | Vesicle-mediated transport |
| GO:0006259 | 2.89237577063e-09 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | DNA metabolic process |
| GO:0006974 | 2.93357770469e-09 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | cellular response to DNA damage stimulus |
| REAC:R-HSA-597592 | 3.77108495747e-09 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Post-translational protein modification |
| GO:0070647 | 1.10044104337e-08 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | protein modification by small protein conjugation or removal |
| GO:0051276 | 4.21227713224e-08 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | chromosome organization |
| REAC:R-HSA-392499 | 1.42999462702e-07 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | Metabolism of proteins |
| CORUM:6482 | 1.62061692851e-07 | 0.3 | GPS1 CUL4B COPS2 | CUL4B-DDB1-DTL-CSN complex |
| GO:0006508 | 7.07530051974e-07 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | proteolysis |
| MIRNA:hsa-let-7e-3p | 6.21439650838e-06 | 0.3 | GPS1 COPS6 COPS8 | hsa-let-7e-3p |
| GO:0033554 | 7.94356345543e-06 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | cellular response to stress |
| CORUM:2715 | 0.000843479125085 | 0.2 | GPS1 COPS8 | Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) |
| CORUM:0000000 | 0.00104233586959 | 0.9 | CUL4B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 COPS7A | CORUM root |
| GO:0006950 | 0.00149227944809 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | response to stress |
| GO:0036211 | 0.00434612167046 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | protein modification process |
| GO:0006464 | 0.00434612167046 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | cellular protein modification process |
| GO:0006996 | 0.006775291858 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | organelle organization |
| GO:0043412 | 0.00773899527665 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | macromolecule modification |
| GO:0005654 | 0.00998195755149 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | nucleoplasm |
| GO:0090304 | 0.0247069047225 | 1.0 | COPS7B COPS5 COPS3 COPS4 COPS6 COPS8 COPS2 GPS1 CUL4B COPS7A | nucleic acid metabolic process |
| WP:000000 | 0.0400621463691 | 0.9 | COPS7B COPS5 CUL4B COPS4 COPS6 COPS8 COPS2 COPS3 COPS7A | WIKIPATHWAYS |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COPS4 | COPS3 | 1.0 | 0.949 | hein_WMM bioplex (COPS3) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| COPS4 | COPS6 | 1.0 | 0.949 | hein_WMM bioplex (COPS6) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS6 | COPS2 | 1.0 | 0.949 | hein_WMM bioplex (COPS2,COPS6) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| COPS6 | COPS7B | 1.0 | 0.949 | bioplex (COPS6,COPS7B) bioplex_WMM Guru boldt Malo fraction boldt_WMM |
| COPS8 | COPS7A | 1.0 | 0.949 | hein_WMM bioplex (COPS8) bioplex_WMM hein (COPS7A) Malo fraction boldt_WMM |
| COPS6 | COPS8 | 1.0 | 0.949 | hein_WMM bioplex (COPS6,COPS8) bioplex_WMM boldt (COPS8) Malo gupta_WMM fraction boldt_WMM |
| COPS4 | COPS2 | 1.0 | 0.949 | hein_WMM bioplex (COPS2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| GPS1 | COPS8 | 1.0 | 0.949 | hein_WMM bioplex (COPS8) bioplex_WMM boldt (COPS8) youn_WMM gupta_WMM fraction boldt_WMM |
| COPS3 | COPS6 | 1.0 | 0.949 | hein_WMM bioplex (COPS3,COPS6) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS2 | COPS7A | 1.0 | 0.949 | hein_WMM bioplex (COPS2) bioplex_WMM Guru hein (COPS7A) fraction boldt_WMM |
| COPS4 | COPS8 | 1.0 | 0.949 | hein_WMM bioplex (COPS8) bioplex_WMM boldt (COPS8) youn_WMM gupta_WMM fraction boldt_WMM |
| GPS1 | COPS6 | 1.0 | 0.949 | hein_WMM bioplex (COPS6) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS4 | COPS5 | 1.0 | 0.949 | hein_WMM bioplex (COPS5) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM |
| COPS7B | COPS8 | 1.0 | 0.949 | bioplex (COPS7B,COPS8) bioplex_WMM boldt (COPS8) youn_WMM Malo fraction boldt_WMM |
| COPS5 | COPS6 | 1.0 | 0.949 | hein_WMM bioplex (COPS5,COPS6) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS8 | COPS2 | 1.0 | 0.949 | hein_WMM bioplex (COPS2,COPS8) bioplex_WMM boldt (COPS8) youn_WMM fraction boldt_WMM |
| COPS5 | COPS8 | 1.0 | 0.949 | hein_WMM bioplex (COPS5,COPS8) bioplex_WMM boldt (COPS8) youn_WMM fraction boldt_WMM |
| COPS3 | COPS7A | 1.0 | 0.949 | hein_WMM bioplex (COPS3) bioplex_WMM Guru youn_WMM hein (COPS7A) fraction boldt_WMM |
| COPS3 | COPS5 | 1.0 | 0.949 | hein_WMM bioplex (COPS3,COPS5) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS7B | COPS2 | 1.0 | 0.949 | bioplex (COPS2,COPS7B) bioplex_WMM Guru boldt fraction boldt_WMM |
| COPS6 | COPS7A | 1.0 | 0.949 | hein_WMM bioplex (COPS6) bioplex_WMM Guru youn_WMM hein (COPS7A) Malo fraction boldt_WMM |
| COPS4 | GPS1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS5 | COPS7A | 1.0 | 0.949 | hein_WMM bioplex (COPS5) bioplex_WMM Guru youn_WMM hein (COPS7A) fraction boldt_WMM |
| COPS5 | COPS7B | 1.0 | 0.949 | bioplex (COPS5,COPS7B) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| GPS1 | COPS3 | 0.999 | 0.949 | hein_WMM bioplex (COPS3) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COPS6 | CUL4B | 0.998 | 0.941 | hein_WMM bioplex (COPS6) bioplex_WMM boldt youn_WMM hein (CUL4B) gupta_WMM boldt_WMM |
| COPS3 | COPS2 | 0.996 | 0.927 | hein_WMM bioplex (COPS2,COPS3) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| GPS1 | COPS5 | 0.993 | 0.918 | hein_WMM bioplex (COPS5) bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| COPS3 | COPS8 | 0.993 | 0.918 | hein_WMM bioplex (COPS3,COPS8) bioplex_WMM boldt (COPS8) youn_WMM gupta_WMM fraction boldt_WMM |
| COPS4 | COPS7A | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru youn_WMM hein (COPS7A) fraction boldt_WMM |
| GPS1 | COPS2 | 0.988 | 0.901 | hein_WMM bioplex (COPS2) bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| COPS5 | COPS2 | 0.988 | 0.901 | hein_WMM bioplex (COPS2,COPS5) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| GPS1 | COPS7A | 0.988 | 0.901 | hein_WMM bioplex_WMM youn_WMM hein (COPS7A) fraction boldt_WMM |
| COPS3 | COPS7B | 0.906 | 0.829 | bioplex (COPS3,COPS7B) bioplex_WMM boldt youn_WMM boldt_WMM |
| COPS4 | COPS7B | 0.891 | 0.818 | bioplex (COPS7B) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| COPS2 | CUL4B | 0.824 | 0.773 | hein_WMM bioplex (COPS2) bioplex_WMM boldt youn_WMM hein (CUL4B) fraction boldt_WMM |
| COPS8 | CUL4B | 0.821 | 0.773 | hein_WMM bioplex (COPS8) bioplex_WMM boldt (COPS8) youn_WMM hein (CUL4B) gupta_WMM boldt_WMM |
| GPS1 | COPS7B | 0.262 | 0.482 | bioplex (COPS7B) bioplex_WMM boldt youn_WMM boldt_WMM |
| GPS1 | CUL4B | 0.117 | 0.389 | hein_WMM bioplex_WMM boldt youn_WMM hein (CUL4B) gupta_WMM boldt_WMM |
| COPS7B | COPS7A | 0.084 | 0.347 | bioplex (COPS7B) bioplex_WMM boldt_WMM |
| COPS7B | CUL4B | 0.064 | 0.348 | bioplex (COPS7B) bioplex_WMM boldt youn_WMM boldt_WMM |
| COPS7A | CUL4B | 0.024 | 0.211 | hein_WMM bioplex_WMM youn_WMM hein (COPS7A,CUL4B) boldt_WMM |
| COPS3 | CUL4B | 0.008 | 0.086 | hein_WMM bioplex (COPS3) bioplex_WMM boldt youn_WMM hein (CUL4B) gupta_WMM fraction boldt_WMM |
| COPS5 | CUL4B | 0.008 | 0.032 | hein_WMM bioplex (COPS5) bioplex_WMM boldt youn_WMM hein (CUL4B) gupta_WMM fraction boldt_WMM |
| COPS4 | CUL4B | 0.008 | 0.028 | hein_WMM bioplex_WMM boldt youn_WMM hein (CUL4B) gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_05105 has an average edge precision of 0.803 which is ranked 919 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GPS1 | HuMAP2_01049 HuMAP2_05105 HuMAP2_06808 |
| COPS5 | HuMAP2_01049 HuMAP2_05105 HuMAP2_06808 |
| COPS2 | HuMAP2_01049 HuMAP2_04563 HuMAP2_05105 HuMAP2_06808 |
| COPS6 | HuMAP2_01049 HuMAP2_04563 HuMAP2_05105 HuMAP2_06808 |
| COPS7A | HuMAP2_01049 HuMAP2_05105 HuMAP2_06808 |
| COPS3 | HuMAP2_01049 HuMAP2_02848 HuMAP2_05105 HuMAP2_06808 |
| COPS7B | HuMAP2_01049 HuMAP2_02770 HuMAP2_05105 HuMAP2_06808 |
| COPS8 | HuMAP2_01049 HuMAP2_05105 HuMAP2_06808 |
| CUL4B | HuMAP2_05105 HuMAP2_06808 |
| COPS4 | HuMAP2_00888 HuMAP2_01049 HuMAP2_02848 HuMAP2_05105 HuMAP2_06808 |