hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05107
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MEF2B | Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) | UniProt NCBI |
| MEF2B | Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) | UniProt NCBI |
| MEF2A | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | UniProt NCBI |
| MEF2C | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | UniProt NCBI |
| MEF2D | Myocyte-specific enhancer factor 2D | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2029 | 1.90921784494e-12 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Cell Differentiation - Index |
| WP:WP1991 | 5.00033245103e-12 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| WP:WP2023 | 2.06831933202e-11 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Cell Differentiation - Index expanded |
| WP:WP2012 | 2.26530212554e-10 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | miRs in Muscle Cell Differentiation |
| REAC:R-HSA-525793 | 1.14722621228e-09 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Myogenesis |
| WP:WP1541 | 2.25765010164e-09 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Energy Metabolism |
| WP:WP236 | 8.74783160645e-08 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Adipogenesis |
| KEGG:04371 | 1.69526580984e-07 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Apelin signaling pathway |
| KEGG:04022 | 2.8510631747e-07 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | cGMP-PKG signaling pathway |
| KEGG:04928 | 3.94870987e-05 | 0.75 | MEF2C MEF2A MEF2D | Parathyroid hormone synthesis, secretion and action |
| GO:0042826 | 4.48297714516e-05 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | histone deacetylase binding |
| WP:WP437 | 0.000149962934646 | 0.75 | MEF2C MEF2A MEF2D | EGF/EGFR Signaling Pathway |
| GO:0007517 | 0.000594259651486 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | muscle organ development |
| REAC:R-HSA-198753 | 0.00231867248578 | 0.5 | MEF2C MEF2A | ERK/MAPK targets |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | Developmental Biology |
| REAC:R-HSA-198725 | 0.00301045354831 | 0.5 | MEF2C MEF2A | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-450282 | 0.00466369436644 | 0.5 | MEF2C MEF2A | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP23 | 0.0063819591539 | 0.5 | MEF2C MEF2D | B Cell Receptor Signaling Pathway |
| GO:0061061 | 0.00713971525321 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | muscle structure development |
| GO:0000978 | 0.010859578747 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | RNA polymerase II proximal promoter sequence-specific DNA binding |
| REAC:R-HSA-2151201 | 0.0122651619918 | 0.5 | MEF2C MEF2D | Transcriptional activation of mitochondrial biogenesis |
| WP:WP366 | 0.012672821387 | 0.5 | MEF2C MEF2A | TGF-beta Signaling Pathway |
| GO:0000987 | 0.0128783441389 | 1.0 | MEF2B MEF2C MEF2A MEF2B MEF2D | proximal promoter sequence-specific DNA binding |
| WP:WP2380 | 0.0152387809455 | 0.5 | MEF2C MEF2A | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| KEGG:05418 | 0.0153578793248 | 0.5 | MEF2C MEF2A | Fluid shear stress and atherosclerosis |
| GO:0033613 | 0.0189701239271 | 0.75 | MEF2C MEF2A MEF2D | activating transcription factor binding |
| REAC:R-HSA-450294 | 0.0195313767937 | 0.5 | MEF2C MEF2A | MAP kinase activation |
| REAC:R-HSA-400253 | 0.0207977326435 | 0.5 | MEF2C MEF2D | Circadian Clock |
| REAC:R-HSA-448424 | 0.0234490216385 | 0.5 | MEF2C MEF2A | Interleukin-17 signaling |
| REAC:R-HSA-187037 | 0.0262582706021 | 0.5 | MEF2C MEF2A | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-168176 | 0.0331557329305 | 0.5 | MEF2C MEF2A | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.0331557329305 | 0.5 | MEF2C MEF2A | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.0331557329305 | 0.5 | MEF2C MEF2A | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.0347967852364 | 0.5 | MEF2C MEF2A | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0356320611636 | 0.5 | MEF2C MEF2A | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0356320611636 | 0.5 | MEF2C MEF2A | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-1592230 | 0.0381968559025 | 0.5 | MEF2C MEF2D | Mitochondrial biogenesis |
| REAC:R-HSA-168138 | 0.0390714342086 | 0.5 | MEF2C MEF2A | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168188 | 0.0390714342086 | 0.5 | MEF2C MEF2A | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.0390714342086 | 0.5 | MEF2C MEF2A | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 0.0399558314157 | 0.5 | MEF2C MEF2A | Toll Like Receptor 3 (TLR3) Cascade |
| GO:0055012 | 0.0405595771497 | 0.5 | MEF2C MEF2A | ventricular cardiac muscle cell differentiation |
| REAC:R-HSA-166520 | 0.0408500448467 | 0.5 | MEF2C MEF2A | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.041754071825 | 0.5 | MEF2C MEF2A | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.041754071825 | 0.5 | MEF2C MEF2A | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-937061 | 0.042667909674 | 0.5 | MEF2C MEF2A | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.042667909674 | 0.5 | MEF2C MEF2A | MyD88-independent TLR4 cascade |
| CORUM:6097 | 0.0499140284799 | 0.25 | MEF2A | MEF2-NR2F2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MEF2B | MEF2B | 1.0 | 0.949 | bioplex (MEF2B) |
| MEF2C | MEF2B | 0.912 | 0.835 | bioplex (MEF2B) |
| MEF2A | MEF2B | 0.872 | 0.804 | bioplex (MEF2B) |
| MEF2B | MEF2D | 0.44 | 0.584 | bioplex (MEF2B) |
| MEF2C | MEF2B | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MEF2D | MEF2B | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MEF2C | MEF2D | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MEF2A | MEF2B | 0.008 | 0.087 | bioplex_WMM WMM_only |
| MEF2A | MEF2C | 0.008 | 0.087 | bioplex_WMM WMM_only |
| MEF2A | MEF2D | 0.008 | 0.081 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_05107 has an average edge precision of 0.37 which is ranked 3636 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MEF2B | HuMAP2_05107 HuMAP2_05867 |
| MEF2B | HuMAP2_05107 HuMAP2_05867 |
| MEF2A | HuMAP2_03877 HuMAP2_05107 HuMAP2_05867 |
| MEF2C | HuMAP2_05107 HuMAP2_05867 |
| MEF2D | HuMAP2_05107 |