hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05110
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAB5C | Ras-related protein Rab-5C (L1880) (RAB5L) | UniProt NCBI |
| RAB5A | Ras-related protein Rab-5A | UniProt NCBI |
| RAB7A | Ras-related protein Rab-7a | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05146 | 2.97024859397e-06 | 1.0 | RAB5C RAB7A RAB5A | Amoebiasis |
| REAC:R-HSA-8854214 | 5.54847547872e-06 | 1.0 | RAB5C RAB7A RAB5A | TBC/RABGAPs |
| KEGG:04145 | 1.20588724809e-05 | 1.0 | RAB5C RAB7A RAB5A | Phagosome |
| KEGG:05152 | 1.65789009806e-05 | 1.0 | RAB5C RAB7A RAB5A | Tuberculosis |
| REAC:R-HSA-8873719 | 1.70037551742e-05 | 1.0 | RAB5C RAB7A RAB5A | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 4.44066869e-05 | 1.0 | RAB5C RAB7A RAB5A | RAB GEFs exchange GTP for GDP on RABs |
| KEGG:04144 | 6.09806140287e-05 | 1.0 | RAB5C RAB7A RAB5A | Endocytosis |
| REAC:R-HSA-9007101 | 0.000113954833063 | 1.0 | RAB5C RAB7A RAB5A | Rab regulation of trafficking |
| WP:WP4301 | 0.000146652290714 | 0.666666666667 | RAB5C RAB5A | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
| KEGG:04962 | 0.000348719274028 | 0.666666666667 | RAB5C RAB5A | Vasopressin-regulated water reabsorption |
| GO:0019003 | 0.00360649647245 | 1.0 | RAB5C RAB7A RAB5A | GDP binding |
| GO:0032482 | 0.0051907357126 | 1.0 | RAB5C RAB7A RAB5A | Rab protein signal transduction |
| WP:WP4217 | 0.00658696465544 | 0.666666666667 | RAB5A RAB7A | Ebola Virus Pathway on Host |
| KEGG:04014 | 0.00747836674868 | 0.666666666667 | RAB5C RAB5A | Ras signaling pathway |
| WP:WP4223 | 0.0113696258401 | 0.666666666667 | RAB5C RAB5A | Ras Signaling |
| MIRNA:hsa-miR-6759-5p | 0.0144095490831 | 0.666666666667 | RAB5C RAB7A | hsa-miR-6759-5p |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | RAB5C RAB7A RAB5A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | RAB5C RAB7A RAB5A | Vesicle-mediated transport |
| MIRNA:hsa-miR-4437 | 0.0271734899676 | 0.666666666667 | RAB5C RAB7A | hsa-miR-4437 |
| CORUM:2572 | 0.0499776345577 | 0.333333333333 | RAB5A | RAB5-EEA1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB5C | RAB5A | 0.858 | 0.796 | hein_WMM bioplex (RAB5A,RAB5C) bioplex_WMM youn_WMM hein (RAB5A) gupta_WMM boldt_WMM treiber_WMM |
| RAB7A | RAB5C | 0.606 | 0.672 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB7A | RAB5A | 0.27 | 0.483 | bioplex_WMM Guru gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05110 has an average edge precision of 0.65 which is ranked 1649 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAB5C | HuMAP2_01779 HuMAP2_02250 HuMAP2_04626 HuMAP2_05110 HuMAP2_05570 |
| RAB5A | HuMAP2_01779 HuMAP2_02250 HuMAP2_05110 HuMAP2_05570 |
| RAB7A | HuMAP2_00248 HuMAP2_02250 HuMAP2_05110 HuMAP2_05570 HuMAP2_05778 HuMAP2_05948 |