hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05111
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMN1 | Survival motor neuron protein (Component of gems 1) (Gemin-1) | UniProt NCBI |
| SNRNP70 | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | UniProt NCBI |
| DDX20 | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | UniProt NCBI |
| CMTR2 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) | UniProt NCBI |
| GEMIN2 | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | UniProt NCBI |
| GEMIN4 | Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) | UniProt NCBI |
| SNRPC | U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3284 | 9.01288868683e-09 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) |
| CORUM:824 | 9.01288868683e-09 | 0.5 | GEMIN4 GEMIN2 DDX20 | Anti-SMN protein complex |
| CORUM:832 | 4.50508252789e-08 | 0.5 | GEMIN4 GEMIN2 DDX20 | Anti-Sm protein complex |
| CORUM:1752 | 4.50508252789e-08 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN complex |
| CORUM:1751 | 1.89127694841e-07 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN complex |
| CORUM:1749 | 2.7014158649e-07 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN-PolII-RHA complex |
| GO:0120114 | 7.88713252093e-07 | 0.833333333333 | DDX20 GEMIN4 SNRNP70 GEMIN2 SNRPC | Sm-like protein family complex |
| CORUM:1745 | 1.02351294033e-06 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN complex |
| CORUM:1143 | 1.02351294033e-06 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN complex |
| GO:0006397 | 1.75466405335e-05 | 1.0 | SNRNP70 GEMIN2 CMTR2 SNRPC GEMIN4 DDX20 | mRNA processing |
| CORUM:3296 | 2.51655344529e-05 | 0.333333333333 | GEMIN4 DDX20 | SMN complex (GEMIN5,4,3), SMN-independent intermediate |
| GO:0000387 | 2.69127816091e-05 | 0.666666666667 | DDX20 GEMIN4 GEMIN2 SNRPC | spliceosomal snRNP assembly |
| CORUM:1750 | 5.0322056017e-05 | 0.333333333333 | GEMIN4 DDX20 | PPP4C-PPP4R2-Gemin3-Gemin4 complex |
| REAC:R-HSA-191859 | 0.000115897320389 | 0.5 | GEMIN4 GEMIN2 DDX20 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.000115897320389 | 0.5 | GEMIN4 GEMIN2 DDX20 | Metabolism of non-coding RNA |
| REAC:R-HSA-8953854 | 0.000150175559311 | 0.833333333333 | DDX20 GEMIN4 SNRNP70 GEMIN2 SNRPC | Metabolism of RNA |
| CORUM:1746 | 0.000176032589326 | 0.333333333333 | GEMIN4 GEMIN2 | SMN containing complex |
| GO:0032797 | 0.000299339163023 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN complex |
| CORUM:1142 | 0.000301662071994 | 0.333333333333 | GEMIN2 DDX20 | SMN complex |
| GO:0016071 | 0.000589815677807 | 1.0 | SNRNP70 GEMIN2 CMTR2 SNRPC GEMIN4 DDX20 | mRNA metabolic process |
| GO:0006396 | 0.000951885417861 | 1.0 | SNRNP70 GEMIN2 CMTR2 SNRPC GEMIN4 DDX20 | RNA processing |
| KEGG:03013 | 0.0009622006058 | 0.5 | GEMIN4 GEMIN2 DDX20 | RNA transport |
| GO:0000398 | 0.00115243061952 | 0.833333333333 | DDX20 GEMIN4 SNRNP70 GEMIN2 SNRPC | mRNA splicing, via spliceosome |
| GO:0000377 | 0.00115243061952 | 0.833333333333 | DDX20 GEMIN4 SNRNP70 GEMIN2 SNRPC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00120907776661 | 0.833333333333 | DDX20 GEMIN4 SNRNP70 GEMIN2 SNRPC | RNA splicing, via transesterification reactions |
| GO:0034719 | 0.00123252169378 | 0.5 | GEMIN4 GEMIN2 DDX20 | SMN-Sm protein complex |
| GO:0008380 | 0.00270779091032 | 0.833333333333 | DDX20 GEMIN4 SNRNP70 GEMIN2 SNRPC | RNA splicing |
| GO:0022618 | 0.0213715329849 | 0.666666666667 | DDX20 GEMIN4 GEMIN2 SNRPC | ribonucleoprotein complex assembly |
| HPA:046010_03 | 0.0264354692737 | 0.5 | GEMIN4 SNRPC SNRNP70 | smooth muscle; smooth muscle cells[Uncertain,High] |
| GO:0071826 | 0.0281789689517 | 0.666666666667 | DDX20 GEMIN4 GEMIN2 SNRPC | ribonucleoprotein complex subunit organization |
| HPA:050020_03 | 0.0384299204809 | 0.5 | GEMIN4 SNRPC SNRNP70 | spleen; cells in white pulp[Uncertain,High] |
| HPA:050010_03 | 0.0387681239533 | 0.5 | GEMIN4 SNRPC SNRNP70 | spleen; cells in red pulp[Uncertain,High] |
| HPA:011030_03 | 0.0391082704229 | 0.5 | GEMIN4 SNRPC SNRNP70 | colon; peripheral nerve/ganglion[Uncertain,High] |
| WP:WP411 | 0.0423673641592 | 0.333333333333 | SNRNP70 DDX20 | mRNA Processing |
| CORUM:3298 | 0.0499726005494 | 0.166666666667 | GEMIN2 | SMN complex (GEMIN2,5, SMN) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GEMIN4 | DDX20 | 0.997 | 0.93 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM treiber_WMM |
| DDX20 | SNRNP70 | 0.977 | 0.893 | hein_WMM youn (DDX20) bioplex (DDX20,SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) treiber_WMM |
| GEMIN4 | SNRNP70 | 0.888 | 0.818 | hein_WMM bioplex (SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) treiber_WMM |
| GEMIN2 | SNRNP70 | 0.816 | 0.773 | hein_WMM bioplex (GEMIN2,SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) |
| SMN1 | SNRNP70 | 0.809 | 0.77 | hein_WMM bioplex (SNRNP70) bioplex_WMM Guru youn_WMM hein (SMN1,SNRNP70) gupta_WMM fraction treiber_WMM |
| SMN1 | DDX20 | 0.797 | 0.764 | hein_WMM youn (DDX20) bioplex_WMM youn_WMM hein (SMN1) gupta_WMM treiber_WMM |
| SNRPC | SNRNP70 | 0.79 | 0.758 | hein_WMM bioplex (SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) gupta_WMM fraction treiber_WMM |
| SNRNP70 | CMTR2 | 0.536 | 0.641 | bioplex (SNRNP70) bioplex_WMM |
| GEMIN2 | DDX20 | 0.536 | 0.641 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN2) bioplex_WMM youn_WMM |
| GEMIN4 | GEMIN2 | 0.109 | 0.375 | hein_WMM bioplex (GEMIN2) bioplex_WMM youn_WMM |
| SMN1 | GEMIN2 | 0.046 | 0.292 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) treiber_WMM |
| SNRPC | CMTR2 | 0.017 | 0.175 | bioplex_WMM WMM_only |
| GEMIN2 | SNRPC | 0.013 | 0.152 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GEMIN4 | SMN1 | 0.013 | 0.148 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) gupta_WMM |
| GEMIN4 | SNRPC | 0.012 | 0.151 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GEMIN2 | CMTR2 | 0.011 | 0.148 | bioplex_WMM WMM_only |
| GEMIN4 | CMTR2 | 0.01 | 0.13 | bioplex_WMM WMM_only |
| DDX20 | CMTR2 | 0.01 | 0.099 | bioplex_WMM WMM_only |
| SNRPC | DDX20 | 0.01 | 0.105 | hein_WMM youn (DDX20) bioplex_WMM youn_WMM gupta_WMM |
| SMN1 | SNRPC | 0.009 | 0.11 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SMN1 | CMTR2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05111 has an average edge precision of 0.426 which is ranked 3057 out of all 6965 complexes.
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