hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05112
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UMPS | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (EC 4.1.1.23) (OMPdecase)] | UniProt NCBI |
| MVD | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | UniProt NCBI |
| GCDH | Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01100 | 0.0105851300972 | 1.0 | MVD UMPS GCDH | Metabolic pathways |
| WP:WP4189 | 0.0142843877495 | 0.333333333333 | MVD | Mevalonate arm of cholesterol biosynthesis pathway with inhibitors |
| WP:WP3963 | 0.0499785733994 | 0.333333333333 | MVD | Mevalonate pathway |
| WP:WP4519 | 0.0499785733994 | 0.333333333333 | GCDH | Cerebral Organic Acidurias, including diseases |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GCDH | UMPS | 0.207 | 0.455 | hein_WMM bioplex_WMM boldt fraction boldt_WMM |
| MVD | UMPS | 0.043 | 0.269 | fraction |
| MVD | GCDH | 0.0 | 0.008 | fraction |
Images
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Complex HuMAP2_05112 has an average edge precision of 0.244 which is ranked 5470 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UMPS | HuMAP2_05112 HuMAP2_06079 |
| MVD | HuMAP2_00480 HuMAP2_03289 HuMAP2_04677 HuMAP2_05112 HuMAP2_06034 |
| GCDH | HuMAP2_01420 HuMAP2_05112 HuMAP2_06079 |