hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05123
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AFF1 | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | UniProt NCBI |
| MLLT1 | Protein ENL (YEATS domain-containing protein 1) | UniProt NCBI |
| AFF4 | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | UniProt NCBI |
| MLLT3 | Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) | UniProt NCBI |
| EAF2 | ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein) | UniProt NCBI |
| USPL1 | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | UniProt NCBI |
| ELL | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | UniProt NCBI |
| ICE1 | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | UniProt NCBI |
| ELL2 | RNA polymerase II elongation factor ELL2 | UniProt NCBI |
| EAF1 | ELL-associated factor 1 | UniProt NCBI |
| ELL3 | RNA polymerase II elongation factor ELL3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6084 | 3.07118755598e-23 | 0.727272727273 | ELL2 AFF1 AFF4 MLLT1 EAF1 ELL3 ELL MLLT3 | AFF4 super elongation complex (SEC) |
| GO:0008023 | 3.81881917953e-20 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL MLLT3 ELL3 AFF1 | transcription elongation factor complex |
| GO:0006368 | 3.54501901474e-12 | 0.727272727273 | ELL2 EAF2 AFF4 MLLT1 EAF1 ELL3 ELL MLLT3 | transcription elongation from RNA polymerase II promoter |
| GO:0006354 | 3.77097848632e-11 | 0.727272727273 | ELL2 EAF2 AFF4 MLLT1 EAF1 ELL3 ELL MLLT3 | DNA-templated transcription, elongation |
| REAC:R-HSA-75955 | 2.96831384e-10 | 0.545454545455 | AFF4 EAF2 MLLT1 EAF1 ELL MLLT3 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 2.96831384e-10 | 0.545454545455 | AFF4 EAF2 MLLT1 EAF1 ELL MLLT3 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-674695 | 2.29153342019e-09 | 0.545454545455 | AFF4 EAF2 MLLT1 EAF1 ELL MLLT3 | RNA Polymerase II Pre-transcription Events |
| GO:0044451 | 2.3325386199e-09 | 1.0 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 AFF1 | nucleoplasm part |
| REAC:R-HSA-73857 | 1.0138617583e-06 | 0.818181818182 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL MLLT3 ELL3 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 2.67031412789e-06 | 0.818181818182 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL MLLT3 ELL3 | Gene expression (Transcription) |
| REAC:R-HSA-6807505 | 3.957059955e-05 | 0.363636363636 | ELL ELL3 ICE1 ELL2 | RNA polymerase II transcribes snRNA genes |
| GO:0009301 | 4.81940792929e-05 | 0.454545454545 | ELL USPL1 ELL3 ICE1 ELL2 | snRNA transcription |
| CORUM:1457 | 0.000100616904936 | 0.181818181818 | MLLT1 AFF1 | AFF1-MLLT1-CBX8 complex |
| GO:0098781 | 0.000290245748564 | 0.454545454545 | ELL USPL1 ELL3 ICE1 ELL2 | ncRNA transcription |
| GO:0005654 | 0.0021313263302 | 1.0 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 AFF1 | nucleoplasm |
| GO:0006366 | 0.00317140457228 | 0.818181818182 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL MLLT3 ELL3 | transcription by RNA polymerase II |
| GO:0006351 | 0.00318022671358 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | transcription, DNA-templated |
| GO:0097659 | 0.00326399901123 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | nucleic acid-templated transcription |
| GO:0032774 | 0.00334974408485 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | RNA biosynthetic process |
| CORUM:0000000 | 0.00414038065946 | 0.818181818182 | ELL2 EAF2 AFF4 MLLT1 EAF1 ELL3 ELL MLLT3 AFF1 | CORUM root |
| GO:0042795 | 0.0072002593108 | 0.363636363636 | ELL ELL3 ICE1 ELL2 | snRNA transcription by RNA polymerase II |
| KEGG:05202 | 0.00802659911596 | 0.272727272727 | MLLT3 AFF1 MLLT1 | Transcriptional misregulation in cancer |
| GO:0034654 | 0.0133259756596 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | nucleobase-containing compound biosynthetic process |
| GO:0018130 | 0.0159192264253 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | heterocycle biosynthetic process |
| GO:0019438 | 0.0159777502635 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | aromatic compound biosynthetic process |
| GO:0031981 | 0.0170336395485 | 1.0 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 AFF1 | nuclear lumen |
| GO:0035327 | 0.022900928028 | 0.272727272727 | ELL ICE1 AFF4 | transcriptionally active chromatin |
| GO:1901362 | 0.0233098413935 | 0.909090909091 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 | organic cyclic compound biosynthetic process |
| GO:0044428 | 0.0345199601716 | 1.0 | ELL2 EAF2 AFF4 MLLT1 ICE1 EAF1 ELL USPL1 MLLT3 ELL3 AFF1 | nuclear part |
| MIRNA:hsa-miR-4734 | 0.0379948115303 | 0.181818181818 | MLLT1 ELL2 | hsa-miR-4734 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELL | EAF1 | 0.999 | 0.948 | bioplex (EAF1) bioplex_WMM fraction |
| EAF1 | ELL3 | 0.998 | 0.945 | bioplex (EAF1,ELL3) bioplex_WMM |
| MLLT1 | AFF4 | 0.997 | 0.93 | hein_WMM bioplex_WMM youn_WMM hein (MLLT1) Malo fraction |
| ELL2 | EAF1 | 0.995 | 0.923 | bioplex (EAF1) bioplex_WMM |
| EAF2 | ELL3 | 0.995 | 0.923 | bioplex (ELL3) bioplex_WMM |
| ELL2 | AFF4 | 0.991 | 0.911 | hein_WMM bioplex (AFF4) bioplex_WMM hein (ELL2) |
| AFF4 | ELL3 | 0.981 | 0.896 | bioplex (AFF4,ELL3) bioplex_WMM |
| ICE1 | EAF1 | 0.966 | 0.876 | bioplex (EAF1) bioplex_WMM |
| EAF2 | EAF1 | 0.891 | 0.819 | bioplex (EAF1) bioplex_WMM |
| AFF1 | ELL3 | 0.877 | 0.811 | bioplex (ELL3) bioplex_WMM |
| MLLT1 | ELL3 | 0.876 | 0.811 | bioplex (ELL3) bioplex_WMM |
| ICE1 | ELL3 | 0.74 | 0.739 | bioplex (ELL3) bioplex_WMM |
| AFF4 | EAF1 | 0.342 | 0.531 | bioplex (AFF4,EAF1) bioplex_WMM fraction |
| MLLT3 | ELL3 | 0.206 | 0.453 | bioplex (ELL3) bioplex_WMM |
| ELL | AFF4 | 0.193 | 0.446 | hein_WMM bioplex (AFF4) bioplex_WMM youn_WMM fraction |
| EAF1 | USPL1 | 0.16 | 0.418 | bioplex (EAF1) bioplex_WMM |
| AFF1 | MLLT1 | 0.155 | 0.415 | hein_WMM bioplex_WMM hein (AFF1,MLLT1) |
| MLLT3 | MLLT1 | 0.133 | 0.406 | hein_WMM bioplex_WMM youn_WMM hein (MLLT1) |
| MLLT1 | EAF1 | 0.113 | 0.38 | bioplex (EAF1) bioplex_WMM fraction |
| MLLT3 | AFF1 | 0.094 | 0.357 | hein_WMM bioplex_WMM hein (AFF1) |
| AFF1 | AFF4 | 0.079 | 0.353 | hein_WMM bioplex_WMM hein (AFF1) |
| EAF2 | AFF4 | 0.05 | 0.296 | bioplex (AFF4) bioplex_WMM |
| AFF1 | ELL2 | 0.05 | 0.295 | hein_WMM bioplex_WMM hein (AFF1,ELL2) |
| MLLT3 | ELL2 | 0.038 | 0.266 | hein_WMM bioplex_WMM hein (ELL2) |
| MLLT1 | ELL2 | 0.036 | 0.264 | hein_WMM bioplex_WMM hein (ELL2,MLLT1) |
| MLLT3 | AFF4 | 0.032 | 0.246 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MLLT1 | ELL | 0.015 | 0.143 | hein_WMM bioplex_WMM youn_WMM hein (MLLT1) fraction |
| AFF1 | EAF1 | 0.014 | 0.137 | bioplex (EAF1) bioplex_WMM |
| EAF2 | ELL2 | 0.014 | 0.143 | bioplex_WMM WMM_only |
| ELL2 | ELL3 | 0.014 | 0.143 | bioplex_WMM WMM_only |
| EAF2 | ELL | 0.013 | 0.151 | bioplex_WMM WMM_only |
| ELL | ICE1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AFF1 | EAF2 | 0.012 | 0.145 | bioplex_WMM WMM_only |
| MLLT3 | ELL | 0.012 | 0.146 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MLLT1 | EAF2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| ELL | ELL2 | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| EAF2 | ICE1 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| AFF1 | ICE1 | 0.01 | 0.131 | bioplex_WMM WMM_only |
| ICE1 | AFF4 | 0.01 | 0.12 | bioplex_WMM youn_WMM WMM_only |
| MLLT3 | EAF2 | 0.01 | 0.097 | bioplex_WMM WMM_only |
| MLLT1 | ICE1 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| ELL2 | USPL1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| ICE1 | USPL1 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| MLLT3 | ICE1 | 0.009 | 0.1 | bioplex_WMM youn_WMM WMM_only |
| USPL1 | ELL3 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| EAF2 | USPL1 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| AFF1 | USPL1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| ELL | USPL1 | 0.009 | 0.099 | bioplex_WMM WMM_only |
| MLLT1 | USPL1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| AFF4 | USPL1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| MLLT3 | USPL1 | 0.008 | 0.071 | bioplex_WMM WMM_only |
| ICE1 | ELL2 | 0.008 | 0.069 | hein_WMM bioplex_WMM WMM_only |
| AFF1 | ELL | 0.008 | 0.015 | hein_WMM bioplex_WMM hein (AFF1) |
| ELL | ELL3 | 0.005 | 0.014 | bioplex (ELL3) bioplex_WMM |
| MLLT3 | EAF1 | 0.0 | 0.003 | bioplex (EAF1) bioplex_WMM |
Images
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Complex HuMAP2_05123 has an average edge precision of 0.34 which is ranked 4114 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AFF1 | HuMAP2_01292 HuMAP2_04584 HuMAP2_05123 HuMAP2_05344 |
| MLLT1 | HuMAP2_01292 HuMAP2_03842 HuMAP2_04584 HuMAP2_05123 |
| AFF4 | HuMAP2_01292 HuMAP2_03842 HuMAP2_04584 HuMAP2_05123 |
| MLLT3 | HuMAP2_01292 HuMAP2_05123 |
| EAF2 | HuMAP2_01292 HuMAP2_04584 HuMAP2_05123 HuMAP2_05344 |
| USPL1 | HuMAP2_01292 HuMAP2_05123 |
| ELL | HuMAP2_01292 HuMAP2_05123 HuMAP2_05136 |
| ICE1 | HuMAP2_01292 HuMAP2_04584 HuMAP2_05123 HuMAP2_05136 |
| ELL2 | HuMAP2_01292 HuMAP2_05123 |
| EAF1 | HuMAP2_01292 HuMAP2_04584 HuMAP2_05123 HuMAP2_05136 |
| ELL3 | HuMAP2_01292 HuMAP2_04584 HuMAP2_05123 HuMAP2_05344 |