hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05127
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXD2 | Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (Exonuclease 3'-5' domain-like-containing protein 2) | UniProt NCBI |
| GRAMD2B | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | UniProt NCBI |
| GRAMD1B | Protein Aster-B (GRAM domain-containing protein 1B) | UniProt NCBI |
| MARCH5 | E3 ubiquitin-protein ligase MARCH5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCH5) | UniProt NCBI |
| GRAMD1C | Protein Aster-C (GRAM domain-containing protein 1C) | UniProt NCBI |
| GRAMD1A | Protein Aster-A (GRAM domain-containing protein 1A) | UniProt NCBI |
| EFCAB14 | EF-hand calcium-binding domain-containing protein 14 | UniProt NCBI |
| CASC4 | Protein CASC4 (Cancer susceptibility candidate gene 4 protein) | UniProt NCBI |
| GTPBP2 | GTP-binding protein 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140268 | 0.000426565421795 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | endoplasmic reticulum-plasma membrane contact site |
| GO:0071397 | 0.000426565421795 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | cellular response to cholesterol |
| GO:0036315 | 0.00125570522129 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | cellular response to sterol |
| GO:0120020 | 0.00276765042703 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | cholesterol transfer activity |
| GO:0070723 | 0.00276765042703 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | response to cholesterol |
| GO:0120015 | 0.00345851718181 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | sterol transfer activity |
| GO:0015248 | 0.00516564812821 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | sterol transporter activity |
| GO:0036314 | 0.00516564812821 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | response to sterol |
| GO:0044232 | 0.0134290861763 | 0.333333333333 | GRAMD1B GRAMD1A GRAMD1C | organelle membrane contact site |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRAMD2B | EFCAB14 | 1.0 | 0.949 | bioplex (GRAMD2B) bioplex_WMM |
| GRAMD2B | GRAMD1B | 0.983 | 0.899 | bioplex (GRAMD2B) bioplex_WMM youn_WMM |
| GRAMD2B | GRAMD1C | 0.904 | 0.828 | bioplex (GRAMD2B) bioplex_WMM |
| GRAMD1A | GRAMD2B | 0.584 | 0.664 | bioplex (GRAMD2B) bioplex_WMM youn_WMM |
| MARCH5 | GRAMD2B | 0.38 | 0.549 | bioplex (GRAMD2B) bioplex_WMM |
| GRAMD2B | EXD2 | 0.168 | 0.426 | bioplex (GRAMD2B) bioplex_WMM |
| GRAMD1C | GRAMD1B | 0.078 | 0.352 | bioplex (GRAMD1B) bioplex_WMM |
| GRAMD2B | CASC4 | 0.036 | 0.264 | bioplex (GRAMD2B) bioplex_WMM |
| GRAMD1A | GRAMD1B | 0.034 | 0.262 | bioplex (GRAMD1B) bioplex_WMM youn_WMM |
| GRAMD1B | GTPBP2 | 0.022 | 0.205 | bioplex (GRAMD1B) bioplex_WMM |
| GRAMD1B | EFCAB14 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| EFCAB14 | CASC4 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| MARCH5 | EFCAB14 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GRAMD1A | GRAMD1C | 0.009 | 0.097 | bioplex_WMM WMM_only |
| GRAMD1C | EFCAB14 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| GRAMD1B | CASC4 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MARCH5 | GRAMD1B | 0.008 | 0.088 | bioplex_WMM WMM_only |
| MARCH5 | CASC4 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| GRAMD1C | CASC4 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| MARCH5 | GRAMD1C | 0.008 | 0.072 | bioplex_WMM WMM_only |
| EFCAB14 | EXD2 | 0.008 | 0.045 | bioplex_WMM WMM_only |
| GRAMD1B | EXD2 | 0.008 | 0.042 | bioplex_WMM WMM_only |
| GRAMD1A | EFCAB14 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| EXD2 | CASC4 | 0.007 | 0.011 | bioplex_WMM WMM_only |
| MARCH5 | EXD2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| GRAMD1C | GTPBP2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| GRAMD1A | CASC4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| MARCH5 | GRAMD1A | 0.007 | 0.008 | bioplex_WMM WMM_only |
| GRAMD1C | EXD2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| GRAMD1A | GTPBP2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| GRAMD1A | EXD2 | 0.006 | 0.007 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_05127 has an average edge precision of 0.21 which is ranked 6032 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EXD2 | HuMAP2_03515 HuMAP2_05127 |
| GRAMD2B | HuMAP2_01669 HuMAP2_05127 HuMAP2_06967 |
| GRAMD1B | HuMAP2_01669 HuMAP2_05127 HuMAP2_06967 |
| MARCH5 | HuMAP2_00249 HuMAP2_02829 HuMAP2_03845 HuMAP2_05127 HuMAP2_05775 |
| GRAMD1C | HuMAP2_01669 HuMAP2_05127 HuMAP2_06967 |
| GRAMD1A | HuMAP2_01546 HuMAP2_05127 HuMAP2_06967 |
| EFCAB14 | HuMAP2_01669 HuMAP2_05127 HuMAP2_06967 |
| CASC4 | HuMAP2_05127 |
| GTPBP2 | HuMAP2_05127 |