hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05137
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GIGYF1 | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | UniProt NCBI |
| GIGYF2 | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | UniProt NCBI |
| EIF4E2 | Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3) | UniProt NCBI |
| EIF4ENIF1 | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0017148 | 0.000536428901306 | 0.8 | EIF4EBP2 EIF4ENIF1 EIF4E2 GIGYF2 | negative regulation of translation |
| GO:0034249 | 0.000838244988417 | 0.8 | EIF4EBP2 EIF4ENIF1 EIF4E2 GIGYF2 | negative regulation of cellular amide metabolic process |
| GO:0006417 | 0.0194326658217 | 0.8 | EIF4EBP2 EIF4ENIF1 EIF4E2 GIGYF2 | regulation of translation |
| GO:0034248 | 0.0371232263042 | 0.8 | EIF4EBP2 EIF4ENIF1 EIF4E2 GIGYF2 | regulation of cellular amide metabolic process |
| KEGG:03013 | 0.0489206453689 | 0.4 | EIF4EBP2 EIF4E2 | RNA transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GIGYF1 | EIF4E2 | 0.992 | 0.912 | bioplex (EIF4E2) bioplex_WMM boldt boldt_WMM |
| EIF4E2 | GIGYF2 | 0.954 | 0.861 | bioplex (EIF4E2) bioplex_WMM boldt gupta_WMM boldt_WMM |
| EIF4E2 | EIF4ENIF1 | 0.862 | 0.799 | youn (EIF4ENIF1) bioplex (EIF4E2) bioplex_WMM youn_WMM |
| EIF4E2 | EIF4EBP2 | 0.044 | 0.278 | bioplex (EIF4E2) bioplex_WMM |
| GIGYF1 | GIGYF2 | 0.008 | 0.088 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| GIGYF1 | EIF4EBP2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| GIGYF1 | EIF4ENIF1 | 0.008 | 0.082 | bioplex_WMM gupta_WMM WMM_only |
| EIF4ENIF1 | GIGYF2 | 0.008 | 0.013 | youn (EIF4ENIF1) bioplex_WMM gupta_WMM |
| GIGYF2 | EIF4EBP2 | 0.003 | 0.014 | bioplex_WMM gupta_WMM fraction |
| EIF4ENIF1 | EIF4EBP2 | 0.0 | 0.008 | bioplex_WMM fraction |
Images
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Complex HuMAP2_05137 has an average edge precision of 0.314 which is ranked 4422 out of all 6965 complexes.
Related Complexes