hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05141
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS4B | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) | UniProt NCBI |
| ZFYVE19 | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | UniProt NCBI |
| VPS4A | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162588 | 0.00252791438215 | 0.666666666667 | VPS4B VPS4A | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 0.00310931782116 | 0.666666666667 | VPS4B VPS4A | Endosomal Sorting Complex Required For Transport (ESCRT) |
| KEGG:04217 | 0.00510487583083 | 0.666666666667 | VPS4B VPS4A | Necroptosis |
| GO:0044878 | 0.00811409485621 | 0.666666666667 | VPS4A ZFYVE19 | mitotic cytokinesis checkpoint |
| KEGG:04144 | 0.0117748506163 | 0.666666666667 | VPS4B VPS4A | Endocytosis |
| GO:0090611 | 0.0135228859698 | 0.666666666667 | VPS4B VPS4A | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway |
| GO:0009838 | 0.020283420769 | 0.666666666667 | VPS4A ZFYVE19 | abscission |
| GO:0032466 | 0.020283420769 | 0.666666666667 | VPS4A ZFYVE19 | negative regulation of cytokinesis |
| GO:0030496 | 0.0317414555944 | 1.0 | VPS4B VPS4A ZFYVE19 | midbody |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS4A | ZFYVE19 | 1.0 | 0.949 | bioplex (VPS4A) bioplex_WMM |
| VPS4A | VPS4B | 0.996 | 0.927 | bioplex (VPS4A,VPS4B) bioplex_WMM fraction |
| ZFYVE19 | VPS4B | 0.008 | 0.06 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05141 has an average edge precision of 0.645 which is ranked 1670 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS4B | HuMAP2_05141 HuMAP2_05438 HuMAP2_06668 |
| ZFYVE19 | HuMAP2_04495 HuMAP2_05141 HuMAP2_05438 |
| VPS4A | HuMAP2_04495 HuMAP2_05141 HuMAP2_05438 |