hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05152
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPGRIP1L | Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) | UniProt NCBI |
| RPGR | X-linked retinitis pigmentosa GTPase regulator | UniProt NCBI |
| NPHP4 | Nephrocystin-4 (Nephroretinin) | UniProt NCBI |
| NPHP1 | Nephrocystin-1 (Juvenile nephronophthisis 1 protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4656 | 1.39841925682e-05 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Joubert Syndrome |
| CORUM:6381 | 1.50819606993e-05 | 0.5 | NPHP4 NPHP1 | NPHP1-NPHP4-BCAR1 complex |
| HP:0000090 | 2.17602308369e-05 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Nephronophthisis |
| HP:0000556 | 2.81031987663e-05 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Retinal dystrophy |
| CORUM:6681 | 3.01612206104e-05 | 0.5 | NPHP4 RPGRIP1L | DVL2-INVS-NPHP4-RPGRIP1L complex |
| HP:0002612 | 3.49764472726e-05 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Congenital hepatic fibrosis |
| HP:0100957 | 4.03468043517e-05 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Abnormal renal medulla morphology |
| REAC:R-HSA-5620912 | 0.000186058065795 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Anchoring of the basal body to the plasma membrane |
| HP:0001395 | 0.000476501757358 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Hepatic fibrosis |
| HP:0000108 | 0.000636114718594 | 0.5 | NPHP4 NPHP1 | Renal corticomedullary cysts |
| HP:0000518 | 0.000843046683954 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Cataract |
| HP:0000517 | 0.000950073733671 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormality of the lens |
| HP:0005576 | 0.00102214412276 | 0.5 | NPHP4 NPHP1 | Tubulointerstitial fibrosis |
| HP:0030760 | 0.00102214412276 | 0.5 | NPHP4 NPHP1 | Renal fibrosis |
| HP:0000510 | 0.00138633858335 | 0.75 | NPHP4 NPHP1 RPGR | Rod-cone dystrophy |
| REAC:R-HSA-5617833 | 0.00152914291965 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Cilium Assembly |
| HP:0000479 | 0.00174710644872 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal retinal morphology |
| HP:0000092 | 0.00272425312749 | 0.5 | NPHP4 NPHP1 | Tubular atrophy |
| HP:0000639 | 0.00279760531903 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Nystagmus |
| HP:0012547 | 0.00294848825074 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal involuntary eye movements |
| HP:0000505 | 0.00294848825074 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Visual impairment |
| HP:0000103 | 0.00431185527855 | 0.5 | NPHP4 NPHP1 | Polyuria |
| HP:0000107 | 0.00440192443626 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Renal cyst |
| REAC:R-HSA-1852241 | 0.00476848509584 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Organelle biogenesis and maintenance |
| HP:0000504 | 0.00618609857615 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormality of vision |
| HP:0004328 | 0.00637600916282 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal anterior eye segment morphology |
| HP:0001098 | 0.00648647361662 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal fundus morphology |
| HP:0004329 | 0.00657025917884 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal posterior eye segment morphology |
| HP:0002012 | 0.00662656539009 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormality of the abdominal organs |
| GO:0035869 | 0.00710332146687 | 0.75 | NPHP4 NPHP1 RPGRIP1L | ciliary transition zone |
| HP:0001425 | 0.00721180746239 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Heterogeneous |
| HP:0030082 | 0.00796059020261 | 0.5 | NPHP4 NPHP1 | Abnormal drinking behavior |
| HP:0001959 | 0.00796059020261 | 0.5 | NPHP4 NPHP1 | Polydipsia |
| HP:0000822 | 0.00803948285574 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Hypertension |
| GO:1903348 | 0.00811409485621 | 0.5 | NPHP4 NPHP1 | positive regulation of bicellular tight junction assembly |
| HP:0012243 | 0.00904814940852 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal reproductive system morphology |
| HP:0007703 | 0.00998881995999 | 0.75 | NPHP4 NPHP1 RPGR | Abnormality of retinal pigmentation |
| GO:0060271 | 0.0104598779665 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | cilium assembly |
| HP:0032263 | 0.0112489013074 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Increased blood pressure |
| HP:0000083 | 0.0114887691482 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Renal insufficiency |
| HP:0000238 | 0.0116099650177 | 0.75 | RPGR NPHP1 RPGRIP1L | Hydrocephalus |
| GO:0044441 | 0.01169323475 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | ciliary part |
| HP:0002419 | 0.0127153557137 | 0.5 | NPHP1 RPGRIP1L | Molar tooth sign on MRI |
| HP:0002793 | 0.0127391041765 | 0.75 | RPGR NPHP1 RPGRIP1L | Abnormal pattern of respiration |
| GO:0044782 | 0.0128783441389 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | cilium organization |
| HP:0012590 | 0.0142767163782 | 0.5 | NPHP4 NPHP1 | Abnormal urine output |
| HP:0000078 | 0.0143510578436 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormality of the genital system |
| HP:0000496 | 0.0174481816875 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormality of eye movement |
| HP:0011036 | 0.0176695962482 | 0.5 | NPHP4 NPHP1 | Abnormality of renal excretion |
| HP:0030972 | 0.0184741317158 | 0.75 | NPHP4 NPHP1 RPGRIP1L | Abnormal systemic blood pressure |
| HP:0001969 | 0.01857406376 | 0.5 | NPHP4 NPHP1 | Tubulointerstitial abnormality |
| HP:0011844 | 0.0199031996946 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | Abnormal appendicular skeleton morphology |
| GO:0097730 | 0.0244411426287 | 0.75 | NPHP4 NPHP1 RPGR | non-motile cilium |
| HP:0008209 | 0.0266188198793 | 0.5 | NPHP4 NPHP1 | Premature ovarian insufficiency |
| GO:0005929 | 0.0272124122863 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | cilium |
| HP:0002418 | 0.0288545127028 | 0.5 | NPHP1 RPGRIP1L | Abnormality of midbrain morphology |
| HP:0002921 | 0.0295907808511 | 0.75 | RPGR NPHP1 RPGRIP1L | Abnormality of the cerebrospinal fluid |
| HP:0004422 | 0.0400245195282 | 0.5 | NPHP1 RPGRIP1L | Biparietal narrowing |
| GO:0120031 | 0.0400391581053 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | plasma membrane bounded cell projection assembly |
| HP:0010579 | 0.0413775694569 | 0.5 | NPHP4 NPHP1 | Cone-shaped epiphysis |
| HP:0000463 | 0.0418131938681 | 0.75 | RPGR NPHP1 RPGRIP1L | Anteverted nares |
| GO:0030031 | 0.0433740392707 | 1.0 | RPGRIP1L NPHP4 NPHP1 RPGR | cell projection assembly |
| HP:0005288 | 0.0453169017901 | 0.75 | RPGR NPHP1 RPGRIP1L | Abnormality of the nares |
| HP:0003774 | 0.0470133620262 | 0.5 | NPHP4 NPHP1 | Stage 5 chronic kidney disease |
| HP:0031066 | 0.0470133620262 | 0.5 | NPHP4 NPHP1 | Abnormal ovarian physiology |
| HP:0001746 | 0.0470133620262 | 0.5 | RPGR RPGRIP1L | Asplenia |
| GO:0097711 | 0.0484715579516 | 0.75 | NPHP4 NPHP1 RPGRIP1L | ciliary basal body-plasma membrane docking |
| HP:0010451 | 0.048478178044 | 0.5 | RPGR RPGRIP1L | Aplasia/Hypoplasia of the spleen |
| CORUM:6743 | 0.0499140284799 | 0.25 | NPHP1 | AHI1-NPHP1 heterodimer |
| CORUM:6660 | 0.0499140284799 | 0.25 | NPHP4 | LATS1-NPHP4 complex |
| CORUM:6600 | 0.0499140284799 | 0.25 | NPHP1 | NPHP1-PKD1 complex |
| CORUM:6342 | 0.0499140284799 | 0.25 | NPHP4 | Jade-1-NPHP4 complex |
| CORUM:6750 | 0.0499140284799 | 0.25 | NPHP1 | AHI1-NPHP1 heterotetramer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPGRIP1L | RPGR | 1.0 | 0.949 | bioplex (RPGR) bioplex_WMM gupta (RPGR,RPGRIP1L) boldt (RPGRIP1L) boldt_WMM |
| RPGR | NPHP4 | 0.998 | 0.943 | bioplex (RPGR) bioplex_WMM gupta (RPGR) boldt gupta_WMM boldt_WMM |
| NPHP4 | NPHP1 | 0.946 | 0.857 | bioplex_WMM gupta (NPHP1,NPHP4) boldt (NPHP4) gupta_WMM boldt_WMM |
| RPGRIP1L | NPHP4 | 0.912 | 0.835 | bioplex_WMM gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM gupta_WMM boldt_WMM |
| RPGRIP1L | NPHP1 | 0.185 | 0.439 | bioplex_WMM gupta (NPHP1,RPGRIP1L) boldt (RPGRIP1L) gupta_WMM boldt_WMM |
| RPGR | NPHP1 | 0.039 | 0.263 | bioplex (RPGR) bioplex_WMM boldt gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_05152 has an average edge precision of 0.714 which is ranked 1326 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPGRIP1L | HuMAP2_00333 HuMAP2_01782 HuMAP2_05152 |
| RPGR | HuMAP2_00333 HuMAP2_00699 HuMAP2_00864 HuMAP2_01782 HuMAP2_04078 HuMAP2_05152 |
| NPHP4 | HuMAP2_00333 HuMAP2_01782 HuMAP2_05152 |
| NPHP1 | HuMAP2_00333 HuMAP2_01782 HuMAP2_05152 |