hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05159
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK12 | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | UniProt NCBI |
| MAPK13 | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3612 | 8.60662876269e-05 | 1.0 | MAPK13 MAPK12 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| REAC:R-HSA-376172 | 9.21757904306e-05 | 1.0 | MAPK13 MAPK12 | DSCAM interactions |
| WP:WP3869 | 9.42630769247e-05 | 1.0 | MAPK13 MAPK12 | Cannabinoid receptor signaling |
| REAC:R-HSA-171007 | 0.000110610948517 | 1.0 | MAPK13 MAPK12 | p38MAPK events |
| WP:WP2643 | 0.000140835743389 | 1.0 | MAPK13 MAPK12 | Nanoparticle-mediated activation of receptor signaling |
| KEGG:05014 | 0.000186019368773 | 1.0 | MAPK13 MAPK12 | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04664 | 0.000216657853041 | 1.0 | MAPK13 MAPK12 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 0.000216657853041 | 1.0 | MAPK13 MAPK12 | VEGF signaling pathway |
| REAC:R-HSA-167044 | 0.000227925590883 | 1.0 | MAPK13 MAPK12 | Signalling to RAS |
| KEGG:05140 | 0.00023285248044 | 1.0 | MAPK13 MAPK12 | Leishmaniasis |
| WP:WP2371 | 0.000234726238982 | 1.0 | MAPK13 MAPK12 | Parkinsons Disease Pathway |
| KEGG:05133 | 0.00025823865312 | 1.0 | MAPK13 MAPK12 | Pertussis |
| KEGG:05120 | 0.000266992505768 | 1.0 | MAPK13 MAPK12 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04917 | 0.00027589225596 | 1.0 | MAPK13 MAPK12 | Prolactin signaling pathway |
| KEGG:04622 | 0.000294129448977 | 1.0 | MAPK13 MAPK12 | RIG-I-like receptor signaling pathway |
| KEGG:05131 | 0.000294129448977 | 1.0 | MAPK13 MAPK12 | Shigellosis |
| KEGG:05132 | 0.000322579470084 | 1.0 | MAPK13 MAPK12 | Salmonella infection |
| KEGG:04657 | 0.000352342569087 | 1.0 | MAPK13 MAPK12 | IL-17 signaling pathway |
| KEGG:04658 | 0.000362555397177 | 1.0 | MAPK13 MAPK12 | Th1 and Th2 cell differentiation |
| WP:WP3611 | 0.000402760419587 | 1.0 | MAPK13 MAPK12 | Photodynamic therapy-induced AP-1 survival signaling. |
| KEGG:05235 | 0.000461036239468 | 1.0 | MAPK13 MAPK12 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04912 | 0.000472708042999 | 1.0 | MAPK13 MAPK12 | GnRH signaling pathway |
| KEGG:04750 | 0.000472708042999 | 1.0 | MAPK13 MAPK12 | Inflammatory mediator regulation of TRP channels |
| KEGG:04914 | 0.000472708042999 | 1.0 | MAPK13 MAPK12 | Progesterone-mediated oocyte maturation |
| WP:WP3865 | 0.000533163885688 | 1.0 | MAPK13 MAPK12 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:04620 | 0.000533255523815 | 1.0 | MAPK13 MAPK12 | Toll-like receptor signaling pathway |
| KEGG:04659 | 0.000533255523815 | 1.0 | MAPK13 MAPK12 | Th17 cell differentiation |
| KEGG:04625 | 0.000558495798951 | 1.0 | MAPK13 MAPK12 | C-type lectin receptor signaling pathway |
| KEGG:04670 | 0.000558495798951 | 1.0 | MAPK13 MAPK12 | Leukocyte transendothelial migration |
| KEGG:05142 | 0.000558495798951 | 1.0 | MAPK13 MAPK12 | Chagas disease (American trypanosomiasis) |
| WP:WP4538 | 0.000573775250846 | 1.0 | MAPK13 MAPK12 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04660 | 0.000584319664263 | 1.0 | MAPK13 MAPK12 | T cell receptor signaling pathway |
| KEGG:01522 | 0.000584319664263 | 1.0 | MAPK13 MAPK12 | Endocrine resistance |
| KEGG:04933 | 0.000597450443235 | 1.0 | MAPK13 MAPK12 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04668 | 0.000624149693812 | 1.0 | MAPK13 MAPK12 | TNF signaling pathway |
| KEGG:05145 | 0.000637718165416 | 1.0 | MAPK13 MAPK12 | Toxoplasmosis |
| REAC:R-HSA-187687 | 0.000680424925724 | 1.0 | MAPK13 MAPK12 | Signalling to ERKs |
| WP:WP4341 | 0.000727651340845 | 1.0 | MAPK13 MAPK12 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| KEGG:04380 | 0.000766399799344 | 1.0 | MAPK13 MAPK12 | Osteoclast differentiation |
| WP:WP3303 | 0.000774969169973 | 1.0 | MAPK13 MAPK12 | RAC1/PAK1/p38/MMP2 Pathway |
| KEGG:04114 | 0.000827384972793 | 1.0 | MAPK13 MAPK12 | Oocyte meiosis |
| KEGG:04722 | 0.000827384972793 | 1.0 | MAPK13 MAPK12 | Neurotrophin signaling pathway |
| KEGG:04071 | 0.000858752944782 | 1.0 | MAPK13 MAPK12 | Sphingolipid signaling pathway |
| KEGG:04611 | 0.000890704506947 | 1.0 | MAPK13 MAPK12 | Platelet activation |
| KEGG:05135 | 0.000906899134346 | 1.0 | MAPK13 MAPK12 | Yersinia infection |
| KEGG:04068 | 0.000939726081777 | 1.0 | MAPK13 MAPK12 | FoxO signaling pathway |
| REAC:R-HSA-168638 | 0.000997174460113 | 1.0 | MAPK13 MAPK12 | NOD1/2 Signaling Pathway |
| KEGG:04926 | 0.00104170846513 | 1.0 | MAPK13 MAPK12 | Relaxin signaling pathway |
| KEGG:04728 | 0.00105921617042 | 1.0 | MAPK13 MAPK12 | Dopaminergic synapse |
| KEGG:04550 | 0.00109466927365 | 1.0 | MAPK13 MAPK12 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:05418 | 0.00113070596705 | 1.0 | MAPK13 MAPK12 | Fluid shear stress and atherosclerosis |
| KEGG:04261 | 0.00120453012438 | 1.0 | MAPK13 MAPK12 | Adrenergic signaling in cardiomyocytes |
| KEGG:04723 | 0.0012614301666 | 1.0 | MAPK13 MAPK12 | Retrograde endocannabinoid signaling |
| WP:WP75 | 0.00142624133782 | 1.0 | MAPK13 MAPK12 | Toll-like Receptor Signaling Pathway |
| KEGG:04218 | 0.00152317036077 | 1.0 | MAPK13 MAPK12 | Cellular senescence |
| KEGG:05152 | 0.00163040505571 | 1.0 | MAPK13 MAPK12 | Tuberculosis |
| REAC:R-HSA-373752 | 0.00165916422775 | 1.0 | MAPK13 MAPK12 | Netrin-1 signaling |
| KEGG:05161 | 0.00174128718926 | 1.0 | MAPK13 MAPK12 | Hepatitis B |
| KEGG:04621 | 0.00180956723991 | 1.0 | MAPK13 MAPK12 | NOD-like receptor signaling pathway |
| WP:WP4321 | 0.001844277592 | 1.0 | MAPK13 MAPK12 | Thermogenesis |
| KEGG:05167 | 0.00197399377215 | 1.0 | MAPK13 MAPK12 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04015 | 0.00217066366165 | 1.0 | MAPK13 MAPK12 | Rap1 signaling pathway |
| KEGG:05130 | 0.00227250014745 | 1.0 | MAPK13 MAPK12 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-168643 | 0.00230942253115 | 1.0 | MAPK13 MAPK12 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:05169 | 0.00242963180249 | 1.0 | MAPK13 MAPK12 | Epstein-Barr virus infection |
| KEGG:05205 | 0.00256458703081 | 1.0 | MAPK13 MAPK12 | Proteoglycans in cancer |
| WP:WP1449 | 0.00257192893285 | 1.0 | MAPK13 MAPK12 | Regulation of toll-like receptor signaling pathway |
| WP:WP3915 | 0.00284130523568 | 1.0 | MAPK13 MAPK12 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:05170 | 0.00287432751701 | 1.0 | MAPK13 MAPK12 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | MAPK13 MAPK12 | Human cytomegalovirus infection |
| KEGG:04714 | 0.00317122901933 | 1.0 | MAPK13 MAPK12 | Thermogenesis |
| WP:WP4239 | 0.00336999814539 | 1.0 | MAPK13 MAPK12 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4666 | 0.00388974910314 | 1.0 | MAPK13 MAPK12 | Hepatitis B infection |
| WP:WP481 | 0.00438938066897 | 1.0 | MAPK13 MAPK12 | Insulin Signaling |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | MAPK13 MAPK12 | Signaling by NTRK1 (TRKA) |
| KEGG:04010 | 0.00476209584058 | 1.0 | MAPK13 MAPK12 | MAPK signaling pathway |
| REAC:R-HSA-4420097 | 0.00686290657842 | 1.0 | MAPK13 MAPK12 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | MAPK13 MAPK12 | Signaling by NTRKs |
| REAC:R-HSA-194138 | 0.00812990471598 | 1.0 | MAPK13 MAPK12 | Signaling by VEGF |
| WP:WP382 | 0.00889388896944 | 1.0 | MAPK13 MAPK12 | MAPK Signaling Pathway |
| GO:0004707 | 0.0410249304355 | 1.0 | MAPK13 MAPK12 | MAP kinase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPK12 | MAPK13 | 0.989 | 0.905 | bioplex (MAPK12) bioplex_WMM |
Images
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Complex HuMAP2_05159 has an average edge precision of 0.905 which is ranked 530 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK12 | HuMAP2_00819 HuMAP2_05159 |
| MAPK13 | HuMAP2_00819 HuMAP2_05159 |