hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05175
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | UniProt NCBI |
| ELMO3 | Engulfment and cell motility protein 3 | UniProt NCBI |
| DOCK5 | Dedicator of cytokinesis protein 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05131 | 5.63189841402e-07 | 0.571428571429 | DOCK1 ELMO2 ELMO1 ELMO3 | Shigellosis |
| KEGG:05100 | 9.633685482e-07 | 0.571428571429 | DOCK1 ELMO2 ELMO1 ELMO3 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-8849471 | 3.0343270142e-06 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| CORUM:5337 | 1.007158685e-05 | 0.285714285714 | DOCK1 ELMO1 | ELMO1-DOCK1 complex |
| CORUM:5343 | 3.02079974644e-05 | 0.285714285714 | DOCK1 ELMO1 | ELMO1-DOCK1-CRKII complex |
| CORUM:5342 | 3.02079974644e-05 | 0.285714285714 | DOCK1 ELMO1 | ELMO1-DOCK1-RAC1 complex |
| REAC:R-HSA-983231 | 7.13974352246e-05 | 0.571428571429 | DOCK1 DOCK5 DOCK4 DOCK3 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-8848021 | 0.000159984341908 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | Signaling by PTK6 |
| REAC:R-HSA-9006927 | 0.000159984341908 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-2029482 | 0.000341719312652 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 0.000859971139422 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 0.00126876263254 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00163544845671 | 0.428571428571 | DOCK1 ELMO2 ELMO1 | Signaling by VEGF |
| REAC:R-HSA-9006934 | 0.00301271618311 | 0.571428571429 | DOCK1 ELMO2 DOCK3 ELMO1 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-109582 | 0.00890318946488 | 0.571428571429 | DOCK1 DOCK5 DOCK4 DOCK3 | Hemostasis |
| GO:1904694 | 0.00946729163895 | 0.285714285714 | DOCK5 DOCK4 | negative regulation of vascular smooth muscle contraction |
| GO:0051020 | 0.0123799196828 | 0.714285714286 | DOCK1 ELMO1 DOCK5 DOCK4 DOCK3 | GTPase binding |
| GO:0005085 | 0.0187784910979 | 0.571428571429 | DOCK1 DOCK5 DOCK3 ELMO1 | guanyl-nucleotide exchange factor activity |
| CORUM:5341 | 0.0499886427319 | 0.142857142857 | ELMO1 | ELMO1-DOCK2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELMO1 | DOCK1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK3 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK4 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| ELMO1 | DOCK5 | 1.0 | 0.949 | bioplex (DOCK5,ELMO1) bioplex_WMM |
| ELMO2 | ELMO1 | 0.99 | 0.909 | bioplex (ELMO1) bioplex_WMM |
| ELMO2 | DOCK5 | 0.936 | 0.85 | hein_WMM bioplex (DOCK5) bioplex_WMM |
| DOCK1 | ELMO3 | 0.84 | 0.784 | bioplex (ELMO3) bioplex_WMM |
| DOCK3 | ELMO3 | 0.388 | 0.551 | bioplex (ELMO3) bioplex_WMM |
| DOCK5 | ELMO3 | 0.113 | 0.381 | bioplex (ELMO3) bioplex_WMM |
| DOCK4 | ELMO3 | 0.032 | 0.244 | bioplex (ELMO3) bioplex_WMM |
| ELMO2 | DOCK1 | 0.014 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| DOCK4 | DOCK1 | 0.013 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK4 | ELMO2 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK1 | DOCK5 | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| DOCK3 | DOCK1 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| DOCK3 | DOCK5 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| ELMO2 | ELMO3 | 0.011 | 0.142 | bioplex (ELMO3) bioplex_WMM |
| DOCK4 | DOCK3 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| DOCK3 | ELMO2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| DOCK4 | DOCK5 | 0.01 | 0.134 | bioplex_WMM WMM_only |
| ELMO1 | ELMO3 | 0.006 | 0.004 | bioplex (ELMO3) bioplex_WMM |
Images
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Complex HuMAP2_05175 has an average edge precision of 0.426 which is ranked 3064 out of all 6965 complexes.
Related Complexes