hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05176
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NAAA | N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (Acid ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] | UniProt NCBI |
| GLDC | Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) | UniProt NCBI |
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | UniProt NCBI |
| IVD | Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0090110 | 8.3158416118e-13 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | COPII-coated vesicle cargo loading |
| GO:0030127 | 1.3857341134e-12 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | COPII vesicle coat |
| GO:0035459 | 2.79105691639e-11 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | vesicle cargo loading |
| WP:WP1982 | 2.98622916772e-11 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| REAC:R-HSA-983170 | 2.17508889246e-10 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 3.30352397046e-10 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Cargo concentration in the ER |
| GO:0012507 | 2.24345147816e-09 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | ER to Golgi transport vesicle membrane |
| GO:0030120 | 2.95650188867e-09 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | vesicle coat |
| KEGG:04141 | 5.22108856104e-09 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-1655829 | 8.62549377886e-09 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0051668 | 1.23804477687e-08 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | localization within membrane |
| REAC:R-HSA-204005 | 2.41593093687e-08 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | COPII-mediated vesicle transport |
| GO:0090114 | 2.49350135505e-08 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | COPII-coated vesicle budding |
| GO:0048475 | 4.66608951843e-08 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | coated membrane |
| GO:0030117 | 4.66608951843e-08 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | membrane coat |
| GO:0030134 | 4.66608951843e-08 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | COPII-coated ER to Golgi transport vesicle |
| GO:0048194 | 4.66608951843e-08 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | Golgi vesicle budding |
| GO:0030660 | 1.28581290314e-07 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | Golgi-associated vesicle membrane |
| GO:0006900 | 1.94811976869e-07 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | vesicle budding from membrane |
| GO:0030658 | 4.64925794362e-07 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | transport vesicle membrane |
| REAC:R-HSA-2132295 | 6.43331323009e-07 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | MHC class II antigen presentation |
| REAC:R-HSA-8957322 | 9.77386993847e-07 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Metabolism of steroids |
| GO:0030662 | 1.69589077344e-06 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | coated vesicle membrane |
| REAC:R-HSA-199977 | 1.91721757128e-06 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | ER to Golgi Anterograde Transport |
| GO:0005798 | 2.13061948912e-06 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | Golgi-associated vesicle |
| REAC:R-HSA-948021 | 4.28935458091e-06 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Transport to the Golgi and subsequent modification |
| GO:0048208 | 5.5681886824e-06 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | COPII vesicle coating |
| GO:0048207 | 5.5681886824e-06 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | vesicle targeting, rough ER to cis-Golgi |
| GO:0006901 | 7.76645830023e-06 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | vesicle coating |
| GO:0048199 | 1.06086599663e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | vesicle targeting, to, from or within Golgi |
| GO:0006888 | 1.2912856803e-05 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | endoplasmic reticulum to Golgi vesicle-mediated transport |
| CORUM:7139 | 1.34129279418e-05 | 0.222222222222 | SEC23A SEC24B | SEC23-SEC24 adaptor complex |
| GO:0030135 | 2.88227833807e-05 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | coated vesicle |
| GO:0006903 | 3.13057641651e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | vesicle targeting |
| GO:0019886 | 4.20435284897e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 4.45066678801e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 4.70836754049e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| GO:0002474 | 4.70836754049e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of peptide antigen via MHC class I |
| REAC:R-HSA-446203 | 5.83960528802e-05 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Asparagine N-linked glycosylation |
| GO:0030133 | 6.8035937211e-05 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | transport vesicle |
| CORUM:7140 | 8.0427137187e-05 | 0.222222222222 | SEC23A SEC24B | SEC23-SEC24-SCAP-SREBP1c complex |
| KEGG:05130 | 0.000118681936928 | 0.444444444444 | SEC24D SEC24A SEC24C SEC24B | Pathogenic Escherichia coli infection |
| GO:0016050 | 0.000128870816687 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | vesicle organization |
| CORUM:7141 | 0.000134003222308 | 0.222222222222 | SEC23A SEC24B | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| REAC:R-HSA-983169 | 0.000159508485545 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Class I MHC mediated antigen processing & presentation |
| GO:0048193 | 0.00045729314833 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | Golgi vesicle transport |
| GO:0051650 | 0.000767667739435 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | establishment of vesicle localization |
| GO:0002478 | 0.00089783193896 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of exogenous peptide antigen |
| GO:0019884 | 0.000954574144143 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of exogenous antigen |
| GO:0051648 | 0.000983997141036 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | vesicle localization |
| GO:0048002 | 0.00121080773647 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation of peptide antigen |
| REAC:R-HSA-199991 | 0.00195631741083 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Membrane Trafficking |
| GO:0019882 | 0.00220667392396 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | antigen processing and presentation |
| REAC:R-HSA-5653656 | 0.00254123488563 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Vesicle-mediated transport |
| REAC:R-HSA-1430728 | 0.00284109424642 | 0.777777777778 | SEC24D IVD GLDC SEC24A SEC23A SEC24B SEC24C | Metabolism |
| REAC:R-HSA-556833 | 0.00311118327366 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Metabolism of lipids |
| REAC:R-HSA-1280218 | 0.00333032492825 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | Adaptive Immune System |
| GO:0030659 | 0.00486591395597 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | cytoplasmic vesicle membrane |
| GO:0012506 | 0.00574865750442 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | vesicle membrane |
| HP:0002868 | 0.00629966976086 | 0.222222222222 | SEC23A SEC24D | Narrow iliac wings |
| HP:0003108 | 0.0101181244364 | 0.222222222222 | IVD GLDC | Hyperglycinuria |
| GO:0008270 | 0.0171061744244 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | zinc ion binding |
| GO:0061024 | 0.0186258588198 | 0.666666666667 | SEC24D SEC23B SEC24A SEC24C SEC23A SEC24B | membrane organization |
| GO:0051656 | 0.0233435811899 | 0.555555555556 | SEC24D SEC23A SEC24A SEC24C SEC24B | establishment of organelle localization |
| MIRNA:hsa-miR-203b-3p | 0.0244623746764 | 0.333333333333 | IVD SEC24C SEC24D | hsa-miR-203b-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SEC24C | SEC23A | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24C | SEC23B | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) Malo gupta_WMM fraction |
| SEC23B | SEC24B | 0.966 | 0.875 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| SEC24A | SEC24D | 0.803 | 0.766 | bioplex_WMM Malo fraction |
| SEC23A | SEC24A | 0.776 | 0.752 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23B | SEC24D | 0.679 | 0.708 | bioplex_WMM Malo fraction |
| SEC24C | IVD | 0.659 | 0.696 | bioplex_WMM fraction |
| SEC23A | SEC24D | 0.551 | 0.644 | bioplex_WMM Malo fraction |
| SEC24D | IVD | 0.191 | 0.443 | fraction |
| SEC23A | IVD | 0.163 | 0.42 | bioplex_WMM fraction |
| SEC24C | SEC24B | 0.084 | 0.347 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) gupta_WMM fraction |
| SEC23B | SEC24A | 0.072 | 0.354 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24D | NAAA | 0.048 | 0.296 | bioplex (NAAA) bioplex_WMM |
| SEC24D | GLDC | 0.043 | 0.273 | fraction |
| SEC24C | GLDC | 0.039 | 0.264 | bioplex_WMM fraction |
| SEC24C | SEC24D | 0.039 | 0.264 | bioplex_WMM Malo fraction |
| SEC23B | GLDC | 0.035 | 0.265 | bioplex_WMM fraction |
| SEC24C | SEC24A | 0.023 | 0.207 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| IVD | GLDC | 0.018 | 0.178 | fraction |
| SEC23A | GLDC | 0.009 | 0.116 | fraction treiber_WMM |
| SEC24B | SEC24A | 0.008 | 0.088 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SEC23A | SEC24B | 0.007 | 0.001 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC23B | IVD | 0.007 | 0.006 | bioplex_WMM WMM_only |
| SEC24B | IVD | 0.006 | 0.006 | bioplex_WMM WMM_only |
| SEC24A | IVD | 0.003 | 0.013 | bioplex_WMM fraction |
| SEC24B | SEC24D | 0.0 | 0.014 | bioplex_WMM fraction |
| SEC24A | NAAA | 0.0 | 0.0 | bioplex (NAAA) bioplex_WMM |
Images
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Complex HuMAP2_05176 has an average edge precision of 0.387 which is ranked 3454 out of all 6965 complexes.
Related Complexes