hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05193
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ADGRG5 | Adhesion G-protein coupled receptor G5 (G-protein coupled receptor 114) (G-protein coupled receptor PGR27) | UniProt NCBI |
| PLPPR3 | Phospholipid phosphatase-related protein type 3 (EC 3.1.3.4) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2) | UniProt NCBI |
| PLPPR1 | Phospholipid phosphatase-related protein type 1 (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) | UniProt NCBI |
| PLPP3 | Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) | UniProt NCBI |
| PLPP2 | Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | UniProt NCBI |
| TSPAN10 | Tetraspanin-10 (Tspan-10) (Oculospanin) | UniProt NCBI |
| SLC6A6 | Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008195 | 4.60828413382e-08 | 0.666666666667 | PLPPR3 PLPP3 PLPP2 PLPPR1 | phosphatidate phosphatase activity |
| GO:0042577 | 4.60828413382e-08 | 0.666666666667 | PLPPR3 PLPP3 PLPP2 PLPPR1 | lipid phosphatase activity |
| GO:0046839 | 4.61861792183e-06 | 0.666666666667 | PLPPR3 PLPP3 PLPP2 PLPPR1 | phospholipid dephosphorylation |
| REAC:R-HSA-419408 | 0.0012174763081 | 0.333333333333 | PLPPR3 PLPPR1 | Lysosphingolipid and LPA receptors |
| WP:WP325 | 0.00140863716749 | 0.333333333333 | PLPP3 PLPP2 | Triacylglyceride Synthesis |
| KEGG:04975 | 0.00271009618492 | 0.333333333333 | PLPP3 PLPP2 | Fat digestion and absorption |
| KEGG:00565 | 0.00349258474935 | 0.333333333333 | PLPP3 PLPP2 | Ether lipid metabolism |
| KEGG:00600 | 0.00509862402418 | 0.333333333333 | PLPP3 PLPP2 | Sphingolipid metabolism |
| KEGG:00561 | 0.00921033351998 | 0.333333333333 | PLPP3 PLPP2 | Glycerolipid metabolism |
| REAC:R-HSA-1660661 | 0.012367185342 | 0.333333333333 | PLPP3 PLPP2 | Sphingolipid de novo biosynthesis |
| GO:0030258 | 0.0129505725968 | 0.666666666667 | PLPPR3 PLPP3 PLPP2 PLPPR1 | lipid modification |
| KEGG:00564 | 0.0190270141569 | 0.333333333333 | PLPP3 PLPP2 | Glycerophospholipid metabolism |
| KEGG:04666 | 0.0236020276363 | 0.333333333333 | PLPP3 PLPP2 | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.0241402690929 | 0.333333333333 | PLPP3 PLPP2 | Choline metabolism in cancer |
| GO:0016791 | 0.0333361403904 | 0.666666666667 | PLPPR3 PLPP3 PLPP2 PLPPR1 | phosphatase activity |
| KEGG:04072 | 0.0482240719397 | 0.333333333333 | PLPP3 PLPP2 | Phospholipase D signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLPPR3 | PLPPR1 | 0.401 | 0.561 | bioplex (PLPPR1) bioplex_WMM |
| PLPPR1 | PLPP3 | 0.29 | 0.492 | bioplex (PLPPR1) bioplex_WMM |
| PLPP3 | PLPP2 | 0.246 | 0.47 | bioplex (PLPP2) bioplex_WMM |
| ADGRG5 | PLPPR3 | 0.031 | 0.24 | bioplex (ADGRG5) bioplex_WMM |
| ADGRG5 | SLC6A6 | 0.024 | 0.214 | bioplex (ADGRG5) bioplex_WMM |
| ADGRG5 | TSPAN10 | 0.02 | 0.185 | bioplex (ADGRG5) bioplex_WMM |
| PLPPR3 | PLPP3 | 0.008 | 0.079 | bioplex_WMM WMM_only |
| PLPPR3 | TSPAN10 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SLC6A6 | TSPAN10 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SLC6A6 | PLPPR3 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| SLC6A6 | PLPP3 | 0.007 | 0.001 | gupta_WMM WMM_only |
Images
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Complex HuMAP2_05193 has an average edge precision of 0.21 which is ranked 6024 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ADGRG5 | HuMAP2_01169 HuMAP2_05193 |
| PLPPR3 | HuMAP2_01946 HuMAP2_02780 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 |
| PLPPR1 | HuMAP2_01946 HuMAP2_02780 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 HuMAP2_05688 |
| PLPP3 | HuMAP2_01946 HuMAP2_02780 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 HuMAP2_05688 |
| PLPP2 | HuMAP2_01946 HuMAP2_02919 HuMAP2_03422 HuMAP2_05193 HuMAP2_05688 |
| TSPAN10 | HuMAP2_05193 |
| SLC6A6 | HuMAP2_01486 HuMAP2_05193 HuMAP2_06269 |