hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05194
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HEXB | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | UniProt NCBI |
| HEXA | Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6274 | 1.67592346237e-06 | 1.0 | HEXA HEXB | HEXA-HEXB complex |
| KEGG:00603 | 1.13800084426e-05 | 1.0 | HEXA HEXB | Glycosphingolipid biosynthesis - globo and isoglobo series |
| KEGG:00604 | 1.32766765163e-05 | 1.0 | HEXA HEXB | Glycosphingolipid biosynthesis - ganglio series |
| WP:WP4153 | 1.67661599273e-05 | 1.0 | HEXA HEXB | Degradation pathway of sphingolipids, including diseases |
| KEGG:00531 | 1.98420660024e-05 | 1.0 | HEXA HEXB | Glycosaminoglycan degradation |
| KEGG:00511 | 2.23223242527e-05 | 1.0 | HEXA HEXB | Other glycan degradation |
| HP:0004343 | 5.00914901532e-05 | 1.0 | HEXA HEXB | Abnormality of glycosphingolipid metabolism |
| HP:0010969 | 5.00914901532e-05 | 1.0 | HEXA HEXB | Abnormality of glycolipid metabolism |
| KEGG:00513 | 9.19154528054e-05 | 1.0 | HEXA HEXB | Various types of N-glycan biosynthesis |
| REAC:R-HSA-2160916 | 9.21757904306e-05 | 1.0 | HEXA HEXB | Hyaluronan uptake and degradation |
| REAC:R-HSA-2022857 | 0.000110610948517 | 1.0 | HEXA HEXB | Keratan sulfate degradation |
| HP:0010729 | 0.000120219576368 | 1.0 | HEXA HEXB | Cherry red spot of the macula |
| REAC:R-HSA-2024101 | 0.000130722030065 | 1.0 | HEXA HEXB | CS/DS degradation |
| KEGG:00520 | 0.00015100395818 | 1.0 | HEXA HEXB | Amino sugar and nucleotide sugar metabolism |
| REAC:R-HSA-2142845 | 0.000152509035076 | 1.0 | HEXA HEXB | Hyaluronan metabolism |
| REAC:R-HSA-1638074 | 0.000680424925724 | 1.0 | HEXA HEXB | Keratan sulfate/keratin metabolism |
| KEGG:04142 | 0.00100713074717 | 1.0 | HEXA HEXB | Lysosome |
| HP:0032243 | 0.00108531561999 | 1.0 | HEXA HEXB | Abnormal tissue metabolite concentration |
| REAC:R-HSA-3560782 | 0.00124185928562 | 1.0 | HEXA HEXB | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-1660662 | 0.00130722030065 | 1.0 | HEXA HEXB | Glycosphingolipid metabolism |
| REAC:R-HSA-1793185 | 0.00181167326283 | 1.0 | HEXA HEXB | Chondroitin sulfate/dermatan sulfate metabolism |
| HP:0000630 | 0.00315910331233 | 1.0 | HEXA HEXB | Abnormal retinal artery morphology |
| REAC:R-HSA-428157 | 0.00452666927187 | 1.0 | HEXA HEXB | Sphingolipid metabolism |
| HP:3000036 | 0.00514272632239 | 1.0 | HEXA HEXB | Abnormality of head blood vessel |
| REAC:R-HSA-1630316 | 0.0102315127378 | 1.0 | HEXA HEXB | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.0125744537382 | 1.0 | HEXA HEXB | Diseases of glycosylation |
| GO:0042340 | 0.0247952876258 | 1.0 | HEXA HEXB | keratan sulfate catabolic process |
| REAC:R-HSA-3656248 | 0.0249595281251 | 0.5 | HEXB | Defective HEXB causes GM2G2 |
| REAC:R-HSA-3656234 | 0.0249595281251 | 0.5 | HEXA | Defective HEXA causes GM2G1 |
| CORUM:6275 | 0.0249595281251 | 0.5 | HEXB | HEXB homodimer complex |
| GO:0030207 | 0.029754345151 | 1.0 | HEXA HEXB | chondroitin sulfate catabolic process |
| GO:0030214 | 0.0410249304355 | 1.0 | HEXA HEXB | hyaluronan catabolic process |
| HP:0008046 | 0.0440905296328 | 1.0 | HEXA HEXB | Abnormal retinal vascular morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HEXB | HEXA | 0.033 | 0.253 | hein_WMM bioplex (HEXA) bioplex_WMM |
Images
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Complex HuMAP2_05194 has an average edge precision of 0.253 which is ranked 5337 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HEXB | HuMAP2_00053 HuMAP2_00675 HuMAP2_05194 HuMAP2_05271 |
| HEXA | HuMAP2_00675 HuMAP2_02493 HuMAP2_04293 HuMAP2_05194 |