hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05206
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BAD | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | UniProt NCBI |
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| IFFO1 | Intermediate filament family orphan 1 (Tumor antigen HOM-TES-103) | UniProt NCBI |
| IFFO2 | Intermediate filament family orphan 2 | UniProt NCBI |
| LIG4 | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | UniProt NCBI |
| XRCC4 | DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:344 | 8.39001385941e-06 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:352 | 8.39001385941e-06 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:348 | 8.39001385941e-06 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:345 | 8.39001385941e-06 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:354 | 8.39001385941e-06 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:206 | 8.39001385941e-06 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4 complex |
| CORUM:350 | 2.51655344529e-05 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4-PNK complex |
| CORUM:336 | 2.51655344529e-05 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4-AHNK complex |
| CORUM:359 | 2.51655344529e-05 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV-XRCC4-XLF complex |
| CORUM:1189 | 0.000176032589326 | 0.333333333333 | LIG4 XRCC4 | DNA double-strand break end-joining complex |
| REAC:R-HSA-164843 | 0.000465187760645 | 0.333333333333 | LIG4 XRCC4 | 2-LTR circle formation |
| KEGG:03450 | 0.000487430751368 | 0.333333333333 | LIG4 XRCC4 | Non-homologous end-joining |
| REAC:R-HSA-162592 | 0.000797179114843 | 0.333333333333 | LIG4 XRCC4 | Integration of provirus |
| REAC:R-HSA-162594 | 0.00201328766088 | 0.333333333333 | LIG4 XRCC4 | Early Phase of HIV Life Cycle |
| HP:0000320 | 0.00495018352279 | 0.333333333333 | LIG4 XRCC4 | Bird-like facies |
| HP:0003683 | 0.00584916901642 | 0.333333333333 | LIG4 XRCC4 | Large beaked nose |
| HP:0004430 | 0.00787106080828 | 0.333333333333 | LIG4 XRCC4 | Severe combined immunodeficiency |
| HP:0005387 | 0.0101912456166 | 0.333333333333 | LIG4 XRCC4 | Combined immunodeficiency |
| GO:0032807 | 0.020283420769 | 0.333333333333 | LIG4 XRCC4 | DNA ligase IV complex |
| GO:0033152 | 0.0405595771497 | 0.333333333333 | LIG4 XRCC4 | immunoglobulin V(D)J recombination |
| GO:0005958 | 0.0405595771497 | 0.333333333333 | LIG4 XRCC4 | DNA-dependent protein kinase-DNA ligase 4 complex |
| CORUM:213 | 0.0499726005494 | 0.166666666667 | LIG4 | DNA ligase IV-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC4 | LIG4 | 1.0 | 0.949 | hein_WMM bioplex (XRCC4) bioplex_WMM |
| APTX | XRCC4 | 1.0 | 0.949 | bioplex (XRCC4) bioplex_WMM |
| XRCC4 | IFFO1 | 0.599 | 0.669 | bioplex (XRCC4) bioplex_WMM |
| XRCC4 | IFFO2 | 0.469 | 0.605 | bioplex (XRCC4) bioplex_WMM |
| APTX | BAD | 0.024 | 0.213 | hein_WMM bioplex (APTX) bioplex_WMM |
| IFFO1 | IFFO2 | 0.009 | 0.11 | bioplex_WMM WMM_only |
| LIG4 | IFFO2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| APTX | LIG4 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| APTX | IFFO2 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| LIG4 | IFFO1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| APTX | IFFO1 | 0.008 | 0.037 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05206 has an average edge precision of 0.356 which is ranked 3831 out of all 6965 complexes.
Related Complexes