hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05209
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| REV3L | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | UniProt NCBI |
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | UniProt NCBI |
| POLD3 | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | UniProt NCBI |
| POLD4 | DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) | UniProt NCBI |
| POLD2 | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:297 | 9.07524205488e-13 | 0.8 | POLD2 POLD3 POLD4 POLD1 | PCNA-DNA polymerase delta complex |
| REAC:R-HSA-110313 | 1.23109960631e-11 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| GO:0042575 | 3.57823411637e-11 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA polymerase complex |
| REAC:R-HSA-73893 | 3.76225081583e-11 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA Damage Bypass |
| CORUM:1107 | 3.81057767206e-11 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA synthesome core complex |
| WP:WP186 | 4.47059720878e-11 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Homologous recombination |
| REAC:R-HSA-174437 | 7.66679100486e-11 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-174414 | 1.20471669305e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Processive synthesis on the C-strand of the telomere |
| GO:0043625 | 1.2197780676e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | delta DNA polymerase complex |
| CORUM:1098 | 1.29720178257e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA synthesome complex (13 subunits) |
| GO:0003887 | 2.157262299e-10 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA-directed DNA polymerase activity |
| CORUM:1108 | 2.4762098927e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-69091 | 3.65371807209e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Polymerase switching |
| REAC:R-HSA-5358606 | 3.65371807209e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 3.65371807209e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-174411 | 3.65371807209e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69166 | 3.65371807209e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Removal of the Flap Intermediate |
| REAC:R-HSA-69109 | 3.65371807209e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Leading Strand Synthesis |
| CORUM:1111 | 4.31702996263e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 4.31702996263e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-5358508 | 4.98207499369e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Mismatch Repair |
| REAC:R-HSA-69183 | 4.98207499369e-10 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Processive synthesis on the lagging strand |
| GO:0034061 | 8.05102676183e-10 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA polymerase activity |
| KEGG:03430 | 1.02762940774e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Mismatch repair |
| REAC:R-HSA-69186 | 1.76788755434e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 2.18374366255e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-174417 | 3.87647729286e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03410 | 4.17116504798e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Base excision repair |
| REAC:R-HSA-110373 | 4.61460570955e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 4.61460570955e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| GO:0019985 | 5.39035410816e-09 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | translesion synthesis |
| KEGG:03030 | 6.83119004003e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA replication |
| REAC:R-HSA-110314 | 9.99440778064e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 9.99440778064e-09 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Extension of Telomeres |
| WP:WP466 | 1.00926677532e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA Replication |
| KEGG:03440 | 1.05961812794e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Homologous recombination |
| GO:0000731 | 1.12291179669e-08 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA synthesis involved in DNA repair |
| REAC:R-HSA-5656169 | 1.14744433983e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 1.31129440131e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA strand elongation |
| KEGG:03420 | 1.57362126176e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Nucleotide excision repair |
| GO:0006301 | 1.73567292042e-08 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | postreplication repair |
| REAC:R-HSA-73933 | 1.90901811802e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5696400 | 3.69105881227e-08 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Dual Incision in GG-NER |
| WP:WP4022 | 1.35209832475e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Pyrimidine metabolism |
| REAC:R-HSA-6782210 | 2.31293212985e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 2.46446696587e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 2.46446696587e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 5.1886356556e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 6.0508920703e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Telomere Maintenance |
| REAC:R-HSA-73894 | 6.75134786288e-07 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA Repair |
| REAC:R-HSA-5696399 | 7.01630822759e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-73884 | 8.09278526697e-07 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Base Excision Repair |
| GO:0016779 | 1.0499160419e-06 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | nucleotidyltransferase activity |
| GO:0006297 | 1.07901087813e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nucleotide-excision repair, DNA gap filling |
| GO:0043601 | 1.54127830699e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nuclear replisome |
| REAC:R-HSA-73886 | 1.94622174999e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Chromosome Maintenance |
| GO:0006261 | 2.08264837631e-06 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA-dependent DNA replication |
| REAC:R-HSA-5696398 | 2.09637710842e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Nucleotide Excision Repair |
| GO:0030894 | 2.13806517127e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | replisome |
| GO:0032201 | 2.13806517127e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-69239 | 2.78534254864e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Synthesis of DNA |
| REAC:R-HSA-69306 | 3.63140268773e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA Replication |
| GO:0016035 | 3.6323771075e-06 | 0.6 | POLD2 POLD3 REV3L | zeta DNA polymerase complex |
| GO:0071897 | 3.80356819159e-06 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA biosynthetic process |
| GO:0006298 | 3.83246409504e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | mismatch repair |
| REAC:R-HSA-5693567 | 4.12021471894e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 4.94380388233e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Homology Directed Repair |
| GO:0042769 | 7.17274954203e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA damage response, detection of DNA damage |
| GO:0006296 | 8.04174090024e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| REAC:R-HSA-69242 | 9.2847398572e-06 | 0.8 | POLD2 POLD3 POLD4 POLD1 | S Phase |
| GO:0033683 | 1.00139303444e-05 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nucleotide-excision repair, DNA incision |
| REAC:R-HSA-5693532 | 1.05183097957e-05 | 0.8 | POLD2 POLD3 POLD4 POLD1 | DNA Double-Strand Break Repair |
| GO:0140097 | 1.05770080233e-05 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | catalytic activity, acting on DNA |
| GO:0043596 | 1.2328136433e-05 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nuclear replication fork |
| GO:0006260 | 2.53215219656e-05 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA replication |
| GO:0033260 | 3.29372797631e-05 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nuclear DNA replication |
| GO:0061695 | 3.59850228871e-05 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | transferase complex, transferring phosphorus-containing groups |
| GO:0044786 | 4.46760620155e-05 | 0.8 | POLD2 POLD3 POLD4 POLD1 | cell cycle DNA replication |
| GO:0005657 | 7.72519331369e-05 | 0.8 | POLD2 POLD3 POLD4 POLD1 | replication fork |
| GO:0006283 | 0.000132272122238 | 0.8 | POLD2 POLD3 POLD4 POLD1 | transcription-coupled nucleotide-excision repair |
| GO:0006289 | 0.0005799178998 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nucleotide-excision repair |
| REAC:R-HSA-69278 | 0.00103692271301 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Cell Cycle, Mitotic |
| GO:0090305 | 0.001292590007 | 0.8 | POLD2 POLD3 POLD4 POLD1 | nucleic acid phosphodiester bond hydrolysis |
| GO:0006281 | 0.00130222282902 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA repair |
| GO:0032993 | 0.00170079952717 | 0.8 | POLD2 POLD3 POLD4 POLD1 | protein-DNA complex |
| REAC:R-HSA-1640170 | 0.0021256129161 | 0.8 | POLD2 POLD3 POLD4 POLD1 | Cell Cycle |
| GO:0000723 | 0.00245191852964 | 0.8 | POLD2 POLD3 POLD4 POLD1 | telomere maintenance |
| GO:0051606 | 0.00265571901763 | 0.8 | POLD2 POLD3 POLD4 POLD1 | detection of stimulus |
| GO:0032200 | 0.00342761547193 | 0.8 | POLD2 POLD3 POLD4 POLD1 | telomere organization |
| GO:1990234 | 0.0112296002627 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | transferase complex |
| GO:0006259 | 0.0122301485616 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | DNA metabolic process |
| GO:0006974 | 0.0123166418329 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | cellular response to DNA damage stimulus |
| GO:0016772 | 0.0188407727751 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | transferase activity, transferring phosphorus-containing groups |
| GO:0060249 | 0.0309921425814 | 0.8 | POLD2 POLD3 POLD4 POLD1 | anatomical structure homeostasis |
| CORUM:0000000 | 0.0474603483533 | 1.0 | REV3L POLD2 POLD3 POLD4 POLD1 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLD1 | POLD2 | 0.998 | 0.945 | hein_WMM bioplex (POLD2) bioplex_WMM youn_WMM hein (POLD1) Malo fraction |
| POLD2 | POLD4 | 0.956 | 0.862 | hein_WMM bioplex (POLD2) bioplex_WMM |
| POLD2 | REV3L | 0.454 | 0.595 | bioplex (POLD2) bioplex_WMM |
| POLD2 | POLD3 | 0.061 | 0.336 | hein_WMM bioplex (POLD2) bioplex_WMM youn_WMM fraction |
| POLD1 | POLD4 | 0.018 | 0.176 | hein_WMM bioplex_WMM hein (POLD1) |
| POLD4 | REV3L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| POLD4 | POLD3 | 0.009 | 0.093 | hein_WMM bioplex_WMM WMM_only |
| POLD1 | REV3L | 0.008 | 0.028 | bioplex_WMM gupta_WMM WMM_only |
| REV3L | POLD3 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| POLD1 | POLD3 | 0.004 | 0.016 | hein_WMM bioplex_WMM boldt youn_WMM hein (POLD1) fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_05209 has an average edge precision of 0.315 which is ranked 4412 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| REV3L | HuMAP2_02230 HuMAP2_05209 HuMAP2_06286 |
| POLD1 | HuMAP2_00586 HuMAP2_03648 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |
| POLD3 | HuMAP2_02230 HuMAP2_05209 HuMAP2_06286 |
| POLD4 | HuMAP2_02230 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |
| POLD2 | HuMAP2_02230 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |