hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05212
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | UniProt NCBI |
| CDKN3 | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) | UniProt NCBI |
| MAPK15 | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | UniProt NCBI |
| CCND1 | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | UniProt NCBI |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | UniProt NCBI |
| CCNE1 | G1/S-specific cyclin-E1 | UniProt NCBI |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | UniProt NCBI |
| ZNF2 | Zinc finger protein 2 (Zinc finger protein 2.2) (Zinc finger protein 661) | UniProt NCBI |
| CDK3 | Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | UniProt NCBI |
| CDKN2C | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | UniProt NCBI |
| CCND2 | G1/S-specific cyclin-D2 | UniProt NCBI |
| CCND3 | G1/S-specific cyclin-D3 | UniProt NCBI |
| CCNE2 | G1/S-specific cyclin-E2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP45 | 6.18267845555e-20 | 0.714285714286 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | G1 to S cell cycle control |
| WP:WP179 | 3.89511291277e-17 | 0.714285714286 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | Cell Cycle |
| KEGG:04110 | 4.07172726641e-17 | 0.714285714286 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | Cell cycle |
| GO:0000079 | 1.54268405732e-16 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:1904029 | 2.39845913828e-16 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of cyclin-dependent protein kinase activity |
| REAC:R-HSA-453279 | 1.58054067916e-15 | 0.714285714286 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | Mitotic G1-G1/S phases |
| WP:WP707 | 2.31139166511e-14 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | DNA Damage Response |
| WP:WP1530 | 3.3418608269e-14 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | miRNA Regulation of DNA Damage Response |
| GO:0000082 | 3.60918453817e-14 | 0.785714285714 | CCND1 CDKN1B CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 CDKN2C | G1/S transition of mitotic cell cycle |
| GO:0044843 | 6.92443071671e-14 | 0.785714285714 | CCND1 CDKN1B CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 CDKN2C | cell cycle G1/S phase transition |
| GO:0016538 | 9.57045269892e-14 | 0.571428571429 | CDKN1B CCND1 CCNE1 CCND3 CDKN1A CCND2 CCNE2 CDKN2C | cyclin-dependent protein serine/threonine kinase regulator activity |
| REAC:R-HSA-69231 | 7.1906599862e-13 | 0.5 | CDKN1B CCND1 CCND3 CDKN1C CDKN1A CCND2 CDKN2C | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 7.1906599862e-13 | 0.5 | CDKN1B CCND1 CCND3 CDKN1C CDKN1A CCND2 CDKN2C | G1 Phase |
| KEGG:04115 | 3.43503940977e-12 | 0.5 | CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | p53 signaling pathway |
| WP:WP2261 | 2.83745266002e-11 | 0.5 | CDKN1B CCND1 CCNE1 CDKN1A CDK2 CCND2 CDKN2C | Signaling Pathways in Glioblastoma |
| GO:0019887 | 3.25132964601e-11 | 0.642857142857 | CDKN1B CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | protein kinase regulator activity |
| GO:0000307 | 3.54106861765e-11 | 0.5 | CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | cyclin-dependent protein kinase holoenzyme complex |
| WP:WP2446 | 4.35220519934e-11 | 0.5 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCNE2 | Retinoblastoma Gene in Cancer |
| KEGG:05169 | 6.67614864139e-11 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | Epstein-Barr virus infection |
| WP:WP1545 | 7.08126416337e-11 | 0.357142857143 | CCNE1 CCND1 CCND3 CDKN1B CDKN1A | miRNAs involved in DNA damage response |
| WP:WP4658 | 8.20307149208e-11 | 0.5 | CDKN1B CDK2 CCNE1 CDKN1C CDKN1A CCND1 CCNE2 | Small cell lung cancer |
| KEGG:05203 | 8.30253212195e-11 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | Viral carcinogenesis |
| KEGG:05166 | 1.21142492472e-10 | 0.571428571429 | CDKN2C CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | Human T-cell leukemia virus 1 infection |
| GO:0019207 | 1.29380391164e-10 | 0.642857142857 | CDKN1B CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | kinase regulator activity |
| REAC:R-HSA-6804116 | 1.6591219589e-10 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| GO:0044772 | 4.49636519502e-10 | 0.785714285714 | CCND1 CDKN1B CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 CDKN2C | mitotic cell cycle phase transition |
| KEGG:05162 | 5.09034451617e-10 | 0.5 | CDKN1B CDK2 CCNE1 CCND3 CCND1 CCND2 CCNE2 | Measles |
| REAC:R-HSA-69278 | 5.1286842643e-10 | 0.714285714286 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | Cell Cycle, Mitotic |
| REAC:R-HSA-8849470 | 6.19462860954e-10 | 0.285714285714 | CDK2 CCND1 CDKN1B CCNE1 | PTK6 Regulates Cell Cycle |
| GO:0044770 | 9.10485465628e-10 | 0.785714285714 | CCND1 CDKN1B CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 CDKN2C | cell cycle phase transition |
| KEGG:04934 | 1.01218860096e-09 | 0.5 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 CDKN2C | Cushing syndrome |
| GO:0071900 | 1.08419393323e-09 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of protein serine/threonine kinase activity |
| KEGG:04218 | 1.23430908718e-09 | 0.5 | CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | Cellular senescence |
| GO:2000045 | 1.88753582011e-09 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CDKN2C | regulation of G1/S transition of mitotic cell cycle |
| REAC:R-HSA-187577 | 2.21263755832e-09 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | SCF(Skp2)-mediated degradation of p27/p21 |
| REAC:R-HSA-1640170 | 3.07979295982e-09 | 0.714285714286 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | Cell Cycle |
| WP:WP4172 | 3.38606458447e-09 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | PI3K-Akt Signaling Pathway |
| GO:0000278 | 3.51021769102e-09 | 0.857142857143 | CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | mitotic cell cycle |
| KEGG:04151 | 3.54763249348e-09 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | PI3K-Akt signaling pathway |
| GO:1902806 | 3.89362624216e-09 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CDKN2C | regulation of cell cycle G1/S phase transition |
| KEGG:05165 | 4.85166951278e-09 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | Human papillomavirus infection |
| KEGG:05215 | 6.30980986557e-09 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | Prostate cancer |
| KEGG:05222 | 7.21981882561e-09 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | Small cell lung cancer |
| GO:1902554 | 9.32516346114e-09 | 0.5 | CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | serine/threonine protein kinase complex |
| REAC:R-HSA-69202 | 1.70135913755e-08 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | Cyclin E associated events during G1/S transition |
| GO:0006468 | 1.79693240152e-08 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | protein phosphorylation |
| REAC:R-HSA-69656 | 1.97317857302e-08 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | Cyclin A:Cdk2-associated events at S phase entry |
| GO:0051338 | 2.15879831817e-08 | 0.785714285714 | MAPK15 CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of transferase activity |
| GO:1902911 | 3.2706466608e-08 | 0.5 | CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | protein kinase complex |
| CORUM:1656 | 3.51680443324e-08 | 0.214285714286 | CDK2 CDKN1B CCNE1 | p27-cyclinE-CDK2 complex |
| GO:1903047 | 4.54941643689e-08 | 0.785714285714 | CCND1 CDKN1B CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 CDKN2C | mitotic cell cycle process |
| KEGG:05226 | 6.21452449935e-08 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | Gastric cancer |
| WP:WP2877 | 7.0029154589e-08 | 0.428571428571 | CDKN2C CDK2 CCNE1 CDKN1A CCND1 CDKN1B | Vitamin D Receptor Pathway |
| HP:0006744 | 7.98700049338e-08 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Adrenocortical carcinoma |
| KEGG:05200 | 1.15066553652e-07 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | Pathways in cancer |
| GO:0045859 | 1.20016388544e-07 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of protein kinase activity |
| REAC:R-HSA-6791312 | 1.39491258785e-07 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | TP53 Regulates Transcription of Cell Cycle Genes |
| CORUM:311 | 1.40594241297e-07 | 0.214285714286 | CDK2 CDKN1A CCND1 | Cell cycle kinase complex CDK2 |
| KEGG:05206 | 1.85521280857e-07 | 0.428571428571 | CDKN1B CCND1 CCNE1 CDKN1A CCND2 CCNE2 | MicroRNAs in cancer |
| HP:0003072 | 1.8858156397e-07 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Hypercalcemia |
| GO:0016310 | 2.24557079864e-07 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | phosphorylation |
| REAC:R-HSA-69206 | 2.83381384891e-07 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | G1/S Transition |
| GO:0043549 | 3.12297019461e-07 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of kinase activity |
| CORUM:313 | 3.51290867842e-07 | 0.214285714286 | CCND1 CDKN1A CCND3 | Cell cycle kinase complex CDK5 |
| GO:0051726 | 5.69158965659e-07 | 0.785714285714 | CDKN1B CDKN3 CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CCNE2 CDKN2C | regulation of cell cycle |
| REAC:R-HSA-69200 | 6.70855770654e-07 | 0.214285714286 | CDK2 CCNE2 CCNE1 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| GO:0007049 | 7.18957085065e-07 | 0.857142857143 | CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | cell cycle |
| REAC:R-HSA-69563 | 7.2145099328e-07 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-69580 | 7.2145099328e-07 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69615 | 8.40658302999e-07 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-69242 | 9.56385932055e-07 | 0.428571428571 | CDKN1B CDK2 CCNE1 CDKN1A CCND1 CCNE2 | S Phase |
| HP:0100641 | 1.158825564e-06 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Neoplasm of the adrenal cortex |
| REAC:R-HSA-2559586 | 1.80747248168e-06 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | DNA Damage/Telomere Stress Induced Senescence |
| CORUM:3015 | 1.96396081958e-06 | 0.214285714286 | CDK2 CDKN1B CCNE1 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex |
| WP:WP710 | 2.07322194417e-06 | 0.357142857143 | CCND2 CCND3 CCND1 CDKN1B CDKN1A | DNA Damage Response (only ATM dependent) |
| KEGG:04068 | 2.42152600787e-06 | 0.357142857143 | CCND2 CCND1 CDKN1B CDK2 CDKN1A | FoxO signaling pathway |
| REAC:R-HSA-2559583 | 2.61700934653e-06 | 0.428571428571 | CDKN2C CDK2 CCNE1 CDKN1A CCNE2 CDKN1B | Cellular Senescence |
| GO:0004672 | 4.19500393808e-06 | 0.642857142857 | MAPK15 CCND1 CDK3 CCNE1 CCND3 CDKN1A CDK2 CCND2 CCNE2 | protein kinase activity |
| GO:0022402 | 4.78890070707e-06 | 0.785714285714 | CCND1 CDKN1B CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 CDKN2C | cell cycle process |
| HP:0030404 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Glucagonoma |
| HP:0100522 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Thymoma |
| HP:0030688 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Increased glucagon level |
| HP:0030687 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormal glucagon level |
| HP:0008291 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pituitary corticotropic cell adenoma |
| HP:0012197 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Insulinoma |
| HP:0011761 | 5.15958462144e-06 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pituitary null cell adenoma |
| GO:0007346 | 5.75690892759e-06 | 0.642857142857 | CDKN1B CDK2 CCNE1 CCND3 CDKN1C CDKN1A CCND1 CCND2 CDKN2C | regulation of mitotic cell cycle |
| HP:0100634 | 6.61411764018e-06 | 0.285714285714 | CCND1 CDKN2C CDKN1B CDKN1A | Neuroendocrine neoplasm |
| HP:0100631 | 8.94148250005e-06 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Neoplasm of the adrenal gland |
| HP:0030405 | 1.0313451964e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pancreatic endocrine tumor |
| HP:0008261 | 1.0313451964e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pancreatic islet cell adenoma |
| HP:0008208 | 1.0313451964e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Parathyroid hyperplasia |
| GO:1901990 | 1.08960033368e-05 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CDKN2C | regulation of mitotic cell cycle phase transition |
| HP:0004363 | 1.14106826842e-05 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Abnormal circulating calcium concentration |
| REAC:R-HSA-212436 | 1.33870882691e-05 | 0.642857142857 | CDKN1B CDK2 CCNE1 CCND3 ZNF2 CDKN1A CCND1 CCND2 CCNE2 | Generic Transcription Pathway |
| HP:0100568 | 1.34480524567e-05 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Neoplasm of the endocrine system |
| MIRNA:hsa-miR-503-5p | 1.34827533229e-05 | 0.428571428571 | CCND1 CCNE1 CCND3 CDKN1A CCND2 CCNE2 | hsa-miR-503-5p |
| GO:0090068 | 1.69082075297e-05 | 0.5 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 | positive regulation of cell cycle process |
| HP:0100521 | 1.80385410749e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Neoplasm of the thymus |
| HP:0007449 | 1.80385410749e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Confetti-like hypopigmented macules |
| HP:0011760 | 1.80385410749e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pituitary growth hormone cell adenoma |
| HP:0006767 | 1.80385410749e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pituitary prolactin cell adenoma |
| HP:0010927 | 1.83892061423e-05 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Abnormal blood inorganic cation concentration |
| GO:1901987 | 1.891081699e-05 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CDKN2C | regulation of cell cycle phase transition |
| GO:0016773 | 1.89590624905e-05 | 0.642857142857 | MAPK15 CCND1 CDK3 CCNE1 CCND3 CDKN1A CDK2 CCND2 CCNE2 | phosphotransferase activity, alcohol group as acceptor |
| GO:0006796 | 1.92428451641e-05 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | phosphate-containing compound metabolic process |
| REAC:R-HSA-8848021 | 1.97765014848e-05 | 0.285714285714 | CDK2 CCND1 CDKN1B CCNE1 | Signaling by PTK6 |
| REAC:R-HSA-9006927 | 1.97765014848e-05 | 0.285714285714 | CDK2 CCND1 CDKN1B CCNE1 | Signaling by Non-Receptor Tyrosine Kinases |
| GO:0006793 | 2.19577984993e-05 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | phosphorus metabolic process |
| WP:WP2032 | 2.31207308788e-05 | 0.285714285714 | CCNE1 CDK2 CDKN1B CCND3 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| GO:0061695 | 2.41022634416e-05 | 0.5 | CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | transferase complex, transferring phosphorus-containing groups |
| HP:0012029 | 2.88456745376e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormal urine hormone level |
| HP:0012030 | 2.88456745376e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Increased urinary cortisol level |
| HP:0002044 | 2.88456745376e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Zollinger-Ellison syndrome |
| HP:0008256 | 2.88456745376e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Adrenocortical adenoma |
| GO:0097134 | 3.30579616724e-05 | 0.214285714286 | CDK2 CCNE2 CCNE1 | cyclin E1-CDK2 complex |
| REAC:R-HSA-73857 | 3.44637538954e-05 | 0.642857142857 | CDKN1B CDK2 CCNE1 CCND3 ZNF2 CDKN1A CCND1 CCND2 CCNE2 | RNA Polymerase II Transcription |
| HP:0100007 | 3.78795495629e-05 | 0.285714285714 | CCND1 CDKN2C CDKN1B CDKN1A | Neoplasm of the peripheral nervous system |
| GO:0016301 | 4.00916035919e-05 | 0.642857142857 | MAPK15 CCND1 CDK3 CCNE1 CCND3 CDKN1A CDK2 CCND2 CCNE2 | kinase activity |
| HP:0100570 | 4.32445379223e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Carcinoid tumor |
| CORUM:5560 | 4.36435430165e-05 | 0.142857142857 | CDK2 CCNE1 | CDK2-CCNE1 complex |
| GO:0050790 | 4.4874859907e-05 | 0.785714285714 | MAPK15 CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of catalytic activity |
| GO:0001932 | 4.81281074837e-05 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of protein phosphorylation |
| HP:0001031 | 6.17436813154e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Subcutaneous lipoma |
| HP:0008283 | 6.17436813154e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Fasting hyperinsulinemia |
| KEGG:01522 | 6.33107856213e-05 | 0.285714285714 | CCND1 CDKN2C CDKN1B CDKN1A | Endocrine resistance |
| GO:0045787 | 8.4800985906e-05 | 0.5 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 | positive regulation of cell cycle |
| HP:0020073 | 8.48505208484e-05 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Hypopigmented macule |
| REAC:R-HSA-74160 | 8.84501803431e-05 | 0.642857142857 | CDKN1B CDK2 CCNE1 CCND3 ZNF2 CDKN1A CCND1 CCND2 CCNE2 | Gene expression (Transcription) |
| GO:0030234 | 9.05916821826e-05 | 0.642857142857 | CDKN1B CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | enzyme regulator activity |
| REAC:R-HSA-8934593 | 0.000113226716384 | 0.214285714286 | CCND2 CCND3 CCND1 | Regulation of RUNX1 Expression and Activity |
| GO:0019901 | 0.000113912727737 | 0.571428571429 | CDKN1B CCND1 CCNE1 CCND3 CDKN1A CCND2 CCNE2 CDKN2C | protein kinase binding |
| CORUM:1634 | 0.000130860292961 | 0.142857142857 | CCND1 CDKN1A | CyclinD1-CDK4-p21 complex |
| HP:0003118 | 0.000146911292241 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Increased circulating cortisol level |
| HP:0012334 | 0.000146911292241 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Extrahepatic cholestasis |
| GO:0042325 | 0.000150389760646 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of phosphorylation |
| KEGG:04630 | 0.00020700416654 | 0.285714285714 | CCND2 CCND1 CDKN1A CCND3 | JAK-STAT signaling pathway |
| GO:0016772 | 0.000211332036067 | 0.642857142857 | MAPK15 CCND1 CDK3 CCNE1 CCND3 CDKN1A CDK2 CCND2 CCNE2 | transferase activity, transferring phosphorus-containing groups |
| HP:0002897 | 0.00023346356002 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Parathyroid adenoma |
| HP:0100733 | 0.00023346356002 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Neoplasm of the parathyroid gland |
| REAC:R-HSA-2262752 | 0.000254033308438 | 0.428571428571 | CDKN2C CDK2 CCNE1 CDKN1A CCNE2 CDKN1B | Cellular responses to stress |
| WP:WP3981 | 0.000256343482254 | 0.214285714286 | CCND1 CDKN1B CDKN1A | miRNA regulation of prostate cancer signaling pathways |
| CORUM:312 | 0.00026157999168 | 0.142857142857 | CCND1 CDKN1A | Cell cycle kinase complex CDK4 |
| CORUM:5101 | 0.00026157999168 | 0.142857142857 | CDKN1A CCND3 | CyclinD3-CDK4-CDK6-p21 complex |
| HP:0000854 | 0.000287180540568 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Thyroid adenoma |
| HP:0003165 | 0.000287180540568 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Elevated circulating parathyroid hormone level |
| GO:0019900 | 0.000307889518416 | 0.571428571429 | CDKN1B CCND1 CCNE1 CCND3 CDKN1A CCND2 CCNE2 CDKN2C | kinase binding |
| HP:0010929 | 0.000312325586567 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Abnormal blood cation concentration |
| HP:0011732 | 0.000318524840399 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Abnormality of adrenal morphology |
| GO:1900087 | 0.000360785878699 | 0.285714285714 | CCND2 CCND1 CCND3 CCNE1 | positive regulation of G1/S transition of mitotic cell cycle |
| WP:WP3941 | 0.000364255169475 | 0.214285714286 | CDKN1C CDKN1B CDKN1A | Oxidative Damage |
| GO:0036211 | 0.000376924958966 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | protein modification process |
| GO:0006464 | 0.000376924958966 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | cellular protein modification process |
| HP:0002894 | 0.000378445025335 | 0.285714285714 | CCND1 CDKN2C CDKN1B CDKN1A | Neoplasm of the pancreas |
| GO:0019220 | 0.000408884293121 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of phosphate metabolic process |
| GO:0051174 | 0.000412211903562 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of phosphorus metabolic process |
| HP:0000845 | 0.00041799941853 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Growth hormone excess |
| HP:0011766 | 0.00041799941853 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of the parathyroid morphology |
| WP:WP2516 | 0.000427958594217 | 0.214285714286 | CDK2 CDKN1A CCNE1 | ATM Signaling Pathway |
| REAC:R-HSA-1538133 | 0.000484348943321 | 0.214285714286 | CDK2 CCNE2 CCNE1 | G0 and Early G1 |
| HP:0000843 | 0.000496099236372 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Hyperparathyroidism |
| GO:0031399 | 0.000515780508377 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of protein modification process |
| GO:0007050 | 0.000532206701283 | 0.428571428571 | CDKN1B CDK2 CDKN3 CDKN1A CCND1 CDKN2C | cell cycle arrest |
| WP:WP2586 | 0.000536688745275 | 0.214285714286 | CDK2 CDKN1B CDKN1A | Aryl Hydrocarbon Receptor |
| KEGG:05161 | 0.000553350167484 | 0.285714285714 | CCNE1 CDK2 CDKN1A CCNE2 | Hepatitis B |
| HP:0003111 | 0.00056015086804 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Abnormal blood ion concentration |
| WP:WP1971 | 0.000576620554298 | 0.214285714286 | CDK2 CDKN1B CDKN1A | Integrated Cancer Pathway |
| GO:2000134 | 0.000581417662377 | 0.357142857143 | CDK2 CCND1 CDKN2C CDKN1B CDKN1A | negative regulation of G1/S transition of mitotic cell cycle |
| KEGG:05202 | 0.000582130189757 | 0.285714285714 | CCND2 CDKN2C CDKN1B CDKN1A | Transcriptional misregulation in cancer |
| REAC:R-HSA-2559582 | 0.000582889654502 | 0.285714285714 | CDK2 CDKN2C CDKN1B CDKN1A | Senescence-Associated Secretory Phenotype (SASP) |
| HP:0004398 | 0.000583322718944 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Peptic ulcer |
| GO:1902807 | 0.00061613120339 | 0.357142857143 | CDK2 CCND1 CDKN2C CDKN1B CDKN1A | negative regulation of cell cycle G1/S phase transition |
| WP:WP3998 | 0.00061846923653 | 0.214285714286 | CCND2 CDKN2C CCND1 | Prader-Willi and Angelman Syndrome |
| HP:0032367 | 0.000639942765799 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Abnormal growth hormone level |
| CORUM:310 | 0.000653247592095 | 0.142857142857 | CCND1 CDKN1A | Cell cycle kinase complex CDC2 |
| REAC:R-HSA-8953897 | 0.000731070949813 | 0.428571428571 | CDKN2C CDK2 CCNE1 CDKN1A CCNE2 CDKN1B | Cellular responses to external stimuli |
| WP:WP3611 | 0.000755950482683 | 0.214285714286 | CCND1 CDKN1A CCNE1 | Photodynamic therapy-induced AP-1 survival signaling. |
| HP:0010615 | 0.000787124202209 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Angiofibromas |
| HP:0006476 | 0.000787124202209 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of the pancreatic islet cells |
| HP:0100633 | 0.000787124202209 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Esophagitis |
| HP:0000825 | 0.000787124202209 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Hyperinsulinemic hypoglycemia |
| GO:0043412 | 0.000787716100442 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | macromolecule modification |
| GO:0010564 | 0.00085628882421 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CDKN2C | regulation of cell cycle process |
| HP:0012093 | 0.00090469117326 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of endocrine pancreas physiology |
| HP:0001732 | 0.000921930386677 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Abnormality of the pancreas |
| GO:0065009 | 0.00100294862744 | 0.785714285714 | MAPK15 CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of molecular function |
| GO:1902808 | 0.00111437881698 | 0.285714285714 | CCND2 CCND1 CCND3 CCNE1 | positive regulation of cell cycle G1/S phase transition |
| REAC:R-HSA-69620 | 0.00113062251855 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | Cell Cycle Checkpoints |
| HP:0002717 | 0.00132596742744 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Adrenal overactivity |
| HP:0011792 | 0.00133269112336 | 0.357142857143 | CDKN1C CCND1 CDKN2C CDKN1B CDKN1A | Neoplasm by histology |
| HP:0002893 | 0.00149088659116 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Pituitary adenoma |
| HP:0032148 | 0.00166886750352 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Episodic pain |
| HP:0002574 | 0.00166886750352 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Episodic abdominal pain |
| MIRNA:hsa-miR-196a-5p | 0.0017022610551 | 0.357142857143 | CCND2 CCND1 CDKN1B CCNE2 CDKN1A | hsa-miR-196a-5p |
| WP:WP2572 | 0.00183498747391 | 0.214285714286 | CDKN1C CDKN1B CDKN1A | Primary Focal Segmental Glomerulosclerosis FSGS |
| HP:0100530 | 0.00206596252697 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormal calcium-phosphate regulating hormone level |
| HP:0011731 | 0.00206596252697 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of circulating cortisol level |
| KEGG:05220 | 0.00218939585455 | 0.214285714286 | CCND1 CDKN1B CDKN1A | Chronic myeloid leukemia |
| HP:0012111 | 0.00228604785297 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of circulating glucocorticoid level |
| GO:1990234 | 0.00264207483304 | 0.571428571429 | CDKN1B CDK2 CCNE1 CCND3 CDKN1A CCND1 CCND2 CCNE2 | transferase complex |
| GO:0004861 | 0.00276765042703 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| HP:0040277 | 0.00277171390187 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Neoplasm of the pituitary gland |
| HP:0011750 | 0.00277171390187 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Neoplasm of the anterior pituitary |
| HP:0001012 | 0.00277171390187 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Multiple lipomas |
| REAC:R-HSA-3700989 | 0.00289037340351 | 0.357142857143 | CCNE1 CDK2 CDKN1B CCNE2 CDKN1A | Transcriptional Regulation by TP53 |
| WP:WP4336 | 0.00348622816412 | 0.214285714286 | CCND2 CCND3 CCND1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| GO:0008283 | 0.00355142334343 | 0.642857142857 | MAPK15 CDKN1B CDKN3 CDK3 CDKN1C CDKN1A CDK2 CCND2 CDKN2C | cell population proliferation |
| WP:WP53 | 0.00389181519846 | 0.142857142857 | CDK2 CCNE1 | ID signaling pathway |
| MIRNA:hsa-miR-195-5p | 0.00394553114232 | 0.428571428571 | CCND1 CCNE1 CCND3 CDKN1A CCND2 CCNE2 | hsa-miR-195-5p |
| GO:0045930 | 0.00427041554475 | 0.428571428571 | CDKN2C CCND1 CDKN1C CDKN1A CDK2 CDKN1B | negative regulation of mitotic cell cycle |
| HP:0200013 | 0.00427372510078 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Neoplasm of fatty tissue |
| HP:0012031 | 0.00427372510078 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Lipomatous tumor |
| WP:WP673 | 0.00450864759866 | 0.214285714286 | CCND1 CDKN1B CDKN1A | ErbB Signaling Pathway |
| WP:WP4258 | 0.00483308697841 | 0.214285714286 | CCND2 CCND3 CCND1 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| WP:WP138 | 0.00500089053752 | 0.214285714286 | CCND1 CDKN1A CCNE1 | Androgen receptor signaling pathway |
| WP:WP2431 | 0.00517246893741 | 0.214285714286 | CDK2 CDKN1B CCND1 | Spinal Cord Injury |
| HP:0001001 | 0.00539143972189 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of subcutaneous fat tissue |
| GO:0098772 | 0.00548696476596 | 0.642857142857 | CDKN1B CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | molecular function regulator |
| HP:0004375 | 0.00559173408326 | 0.285714285714 | CCND1 CDKN2C CDKN1B CDKN1A | Neoplasm of the nervous system |
| HP:0000777 | 0.00580294705829 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of the thymus |
| GO:0045786 | 0.00585333622609 | 0.5 | CDKN1B CDKN3 CCND1 CDKN1C CDKN1A CDK2 CDKN2C | negative regulation of cell cycle |
| MIRNA:hsa-miR-4524b-5p | 0.00606579807102 | 0.285714285714 | CCND2 CCND1 CCNE2 CCNE1 | hsa-miR-4524b-5p |
| MIRNA:hsa-miR-4524a-5p | 0.00606579807102 | 0.285714285714 | CCND2 CCND1 CCNE2 CCNE1 | hsa-miR-4524a-5p |
| GO:0004860 | 0.00644260262255 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | protein kinase inhibitor activity |
| KEGG:04114 | 0.0065820698427 | 0.214285714286 | CDK2 CCNE2 CCNE1 | Oocyte meiosis |
| WP:WP399 | 0.00668566008136 | 0.214285714286 | CCND2 CCND3 CCND1 | Wnt Signaling Pathway and Pluripotency |
| MIRNA:hsa-miR-146a-5p | 0.00680951682332 | 0.285714285714 | CCND2 CCND1 CDKN1A CDKN3 | hsa-miR-146a-5p |
| HP:0000834 | 0.00695901401201 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Abnormality of the adrenal glands |
| GO:1901992 | 0.00872181655801 | 0.285714285714 | CCND2 CCND1 CCND3 CCNE1 | positive regulation of mitotic cell cycle phase transition |
| GO:0019210 | 0.00872181655801 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | kinase inhibitor activity |
| WP:WP428 | 0.00895047358668 | 0.214285714286 | CCND2 CCND3 CCND1 | Wnt Signaling |
| REAC:R-HSA-69017 | 0.00923610675298 | 0.214285714286 | CDK2 CCNE2 CCNE1 | CDK-mediated phosphorylation and removal of Cdc6 |
| GO:0044267 | 0.0102189494922 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | cellular protein metabolic process |
| MIRNA:hsa-miR-15b-5p | 0.0103532736022 | 0.428571428571 | CCND1 CCNE1 CCND3 CDKN1A CCND2 CCNE2 | hsa-miR-15b-5p |
| HP:0010614 | 0.0104742778885 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Fibroma |
| GO:0140096 | 0.0112221133071 | 0.714285714286 | MAPK15 CCND1 CDK3 CCNE1 CCND3 CDKN3 CDKN1A CDK2 CCND2 CCNE2 | catalytic activity, acting on a protein |
| GO:0031571 | 0.0115546674255 | 0.285714285714 | CDK2 CCND1 CDKN1B CDKN1A | mitotic G1 DNA damage checkpoint |
| GO:0044819 | 0.0115546674255 | 0.285714285714 | CDK2 CCND1 CDKN1B CDKN1A | mitotic G1/S transition checkpoint |
| HP:0012316 | 0.0117694313437 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Fibrous tissue neoplasm |
| GO:0044783 | 0.0123588651547 | 0.285714285714 | CDK2 CCND1 CDKN1B CDKN1A | G1 DNA damage checkpoint |
| HP:0011767 | 0.0124548409874 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of the parathyroid physiology |
| MIRNA:hsa-miR-892b | 0.0129527960215 | 0.214285714286 | CDK2 CCNE1 CCND1 | hsa-miR-892b |
| MIRNA:hsa-miR-497-5p | 0.0131043647265 | 0.357142857143 | CCNE1 CCND2 CCND1 CCND3 CCNE2 | hsa-miR-497-5p |
| KEGG:05160 | 0.0133803659922 | 0.214285714286 | CDK2 CDKN1A CCND1 | Hepatitis C |
| WP:WP205 | 0.0135483736716 | 0.142857142857 | CCND1 CDKN1B | IL-7 Signaling Pathway |
| MIRNA:hsa-miR-203a-5p | 0.0141508449145 | 0.214285714286 | CCND2 CDKN1B CDKN1A | hsa-miR-203a-5p |
| MIRNA:hsa-miR-424-5p | 0.0144813451797 | 0.357142857143 | CCNE1 CCND2 CCND1 CCND3 CCNE2 | hsa-miR-424-5p |
| HP:0100031 | 0.0146679065289 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Neoplasm of the thyroid gland |
| KEGG:04390 | 0.0151942329623 | 0.214285714286 | CCND2 CCND3 CCND1 | Hippo signaling pathway |
| GO:0032268 | 0.0156639078973 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of cellular protein metabolic process |
| GO:0042127 | 0.0165523962607 | 0.571428571429 | MAPK15 CDKN1B CDKN3 CDK2 CDKN1C CDKN1A CCND2 CDKN2C | regulation of cell population proliferation |
| KEGG:04310 | 0.0168219118682 | 0.214285714286 | CCND2 CCND3 CCND1 | Wnt signaling pathway |
| HP:0007378 | 0.0174165196422 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Neoplasm of the gastrointestinal tract |
| WP:WP34 | 0.0175669592019 | 0.142857142857 | CCND2 CDKN1B | Ovarian Infertility Genes |
| HP:0011747 | 0.0177834746851 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Abnormality of the anterior pituitary |
| GO:1901989 | 0.0180936587739 | 0.285714285714 | CCND2 CCND1 CCND3 CCNE1 | positive regulation of cell cycle phase transition |
| REAC:R-HSA-69052 | 0.0181692817497 | 0.214285714286 | CDK2 CCNE2 CCNE1 | Switching of origins to a post-replicative state |
| GO:0045737 | 0.0183795545963 | 0.214285714286 | CCND2 CCND3 CCND1 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| REAC:R-HSA-198323 | 0.0188288105354 | 0.142857142857 | CDKN1B CDKN1A | AKT phosphorylates targets in the cytosol |
| HP:0000828 | 0.0189064868532 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Abnormality of the parathyroid gland |
| MIRNA:hsa-miR-646 | 0.01943077596 | 0.285714285714 | CCND2 CCND1 CCNE2 CCNE1 | hsa-miR-646 |
| GO:0060255 | 0.0211469658132 | 0.928571428571 | MAPK15 CDKN1B ZNF2 CDK2 CCNE1 CCND3 CDKN1C CDKN3 CDKN1A CCND1 CCND2 CCNE2 CDKN2C | regulation of macromolecule metabolic process |
| MIRNA:hsa-miR-95-3p | 0.022823187435 | 0.142857142857 | CCND1 CDKN1A | hsa-miR-95-3p |
| HP:0004386 | 0.026090620311 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Gastrointestinal inflammation |
| HP:0010514 | 0.026090620311 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Hyperpituitarism |
| HP:0012503 | 0.0263870847301 | 0.285714285714 | CDKN1C CDKN2C CDKN1B CDKN1A | Abnormality of the pituitary gland |
| GO:0019538 | 0.0275648321364 | 0.928571428571 | MAPK15 CCND1 CDKN1B CDKN3 CDK3 CCNE1 CCND3 CDKN1C CDKN1A CDK2 CCND2 CCNE2 CDKN2C | protein metabolic process |
| REAC:R-HSA-9617828 | 0.0280944449975 | 0.142857142857 | CDKN1B CDKN1A | FOXO-mediated transcription of cell cycle genes |
| KEGG:05219 | 0.0284948915127 | 0.142857142857 | CCND1 CDKN1A | Bladder cancer |
| KEGG:05216 | 0.0284948915127 | 0.142857142857 | CCND1 CDKN1A | Thyroid cancer |
| GO:0051246 | 0.0285840229663 | 0.714285714286 | CDKN1B CDKN3 CCND1 CCNE1 CCND3 CDKN1C CDKN1A CCND2 CCNE2 CDKN2C | regulation of protein metabolic process |
| GO:1904030 | 0.0317503511278 | 0.214285714286 | CDKN1C CDKN1B CDKN1A | negative regulation of cyclin-dependent protein kinase activity |
| GO:1904031 | 0.0317503511278 | 0.214285714286 | CCND2 CCND3 CCND1 | positive regulation of cyclin-dependent protein kinase activity |
| MIRNA:hsa-miR-16-1-3p | 0.0324132007039 | 0.214285714286 | CCND2 CCNE1 CCND1 | hsa-miR-16-1-3p |
| MIRNA:hsa-miR-708-5p | 0.0334871906601 | 0.214285714286 | CCND1 CDKN1A CCND3 | hsa-miR-708-5p |
| MIRNA:hsa-miR-3616-3p | 0.0345842311958 | 0.214285714286 | CCND2 CDKN1B CDKN1A | hsa-miR-3616-3p |
| KEGG:04510 | 0.0350883777295 | 0.214285714286 | CCND2 CCND3 CCND1 | Focal adhesion |
| REAC:R-HSA-9634638 | 0.0352867003479 | 0.142857142857 | CCND1 CDKN1B | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| GO:1901991 | 0.0358496555546 | 0.357142857143 | CDK2 CCND1 CDKN2C CDKN1B CDKN1A | negative regulation of mitotic cell cycle phase transition |
| WP:WP2828 | 0.0366733081208 | 0.142857142857 | CCND1 CDKN1A | Bladder Cancer |
| WP:WP2371 | 0.0366733081208 | 0.142857142857 | CCNE2 CCNE1 | Parkinsons Disease Pathway |
| KEGG:04340 | 0.0403228683416 | 0.142857142857 | CCND2 CCND1 | Hedgehog signaling pathway |
| WP:WP4249 | 0.0408788252207 | 0.142857142857 | CCND2 CCND1 | Hedgehog Signaling Pathway |
| GO:1905178 | 0.0410249304355 | 0.142857142857 | CDKN1B CDKN1A | regulation of cardiac muscle tissue regeneration |
| GO:0097135 | 0.0410249304355 | 0.142857142857 | CDK2 CCNE2 | cyclin E2-CDK2 complex |
| GO:1905179 | 0.0410249304355 | 0.142857142857 | CDKN1B CDKN1A | negative regulation of cardiac muscle tissue regeneration |
| REAC:R-HSA-69239 | 0.0420223802119 | 0.214285714286 | CDK2 CCNE2 CCNE1 | Synthesis of DNA |
| HP:0010785 | 0.0453999173521 | 0.214285714286 | CDKN1C CDKN1B CCND1 | Gonadal neoplasm |
| HP:0030448 | 0.0453999173521 | 0.214285714286 | CDKN2C CDKN1B CDKN1A | Soft tissue sarcoma |
| WP:WP306 | 0.0469828487906 | 0.214285714286 | CCND2 CCND3 CCND1 | Focal Adhesion |
| GO:1901988 | 0.049099119723 | 0.357142857143 | CDK2 CCND1 CDKN2C CDKN1B CDKN1A | negative regulation of cell cycle phase transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCNE1 | CDK2 | 1.0 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CDKN1B | CDK2 | 0.999 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) gupta_WMM |
| CDKN1A | CCND3 | 0.999 | 0.949 | hein_WMM bioplex (CCND3) bioplex_WMM hein (CDKN1A) |
| CDK2 | CDKN1C | 0.998 | 0.941 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CDKN1A | CCNE2 | 0.996 | 0.927 | hein_WMM bioplex (CCNE2) bioplex_WMM hein (CDKN1A) |
| CDK2 | CCNE2 | 0.992 | 0.915 | hein_WMM bioplex (CCNE2,CDK2) bioplex_WMM hein (CDK2) |
| CDK2 | CDKN1A | 0.971 | 0.882 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2,CDKN1A) |
| CDKN1B | CCND3 | 0.93 | 0.846 | hein_WMM bioplex (CCND3) bioplex_WMM |
| CCND3 | CDKN1C | 0.747 | 0.741 | hein_WMM bioplex (CCND3) bioplex_WMM |
| CDK2 | CDK3 | 0.555 | 0.647 | bioplex (CDK2,CDK3) bioplex_WMM youn_WMM gupta_WMM |
| CDKN1A | CCND2 | 0.463 | 0.6 | bioplex (CCND2) bioplex_WMM |
| CDK2 | CDKN3 | 0.458 | 0.597 | bioplex (CDK2) bioplex_WMM |
| CCND3 | ZNF2 | 0.445 | 0.589 | bioplex (CCND3) bioplex_WMM |
| CDK2 | CCND3 | 0.356 | 0.539 | hein_WMM bioplex (CCND3) bioplex_WMM hein (CDK2) |
| CDK2 | MAPK15 | 0.331 | 0.521 | bioplex (CDK2) bioplex_WMM |
| CDKN2C | CCND3 | 0.145 | 0.409 | bioplex (CCND3) bioplex_WMM |
| CDKN1B | CCND1 | 0.133 | 0.406 | hein_WMM bioplex (CCND1) bioplex_WMM hein (CCND1) |
| CDKN1B | CCND2 | 0.119 | 0.393 | bioplex (CCND2) bioplex_WMM |
| CCND2 | CDKN1C | 0.111 | 0.381 | bioplex (CCND2) bioplex_WMM |
| CCND1 | CDKN1C | 0.099 | 0.359 | hein_WMM bioplex (CCND1) bioplex_WMM |
| CCND1 | CDKN1A | 0.065 | 0.347 | hein_WMM bioplex (CCND1) bioplex_WMM |
| CDKN1B | CDKN1C | 0.036 | 0.267 | hein_WMM bioplex_WMM WMM_only |
| CDKN2C | CCND1 | 0.035 | 0.261 | bioplex (CCND1) bioplex_WMM |
| CDKN1B | CDKN1A | 0.029 | 0.232 | hein_WMM bioplex_WMM WMM_only |
| CDKN1A | CDKN1C | 0.029 | 0.233 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CCNE2 | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CDKN1B | 0.015 | 0.152 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CDKN1A | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| CDK3 | CDKN3 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| CDKN1C | CDKN3 | 0.01 | 0.131 | bioplex_WMM WMM_only |
| CDKN1B | CCNE2 | 0.01 | 0.126 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CDKN1C | 0.01 | 0.117 | hein_WMM bioplex_WMM WMM_only |
| CDKN1C | CCNE2 | 0.01 | 0.12 | hein_WMM bioplex_WMM WMM_only |
| CDKN1B | CDKN3 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| CDKN1A | CDKN3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| CDKN1B | CDKN2C | 0.009 | 0.101 | bioplex_WMM WMM_only |
| MAPK15 | CDKN3 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| CDKN2C | CDKN1A | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CDKN2C | CDKN1C | 0.009 | 0.099 | bioplex_WMM WMM_only |
| CCND3 | CCNE2 | 0.009 | 0.099 | hein_WMM WMM_only |
| CCND2 | CCND3 | 0.008 | 0.096 | bioplex_WMM WMM_only |
| CCNE2 | MAPK15 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| CCNE1 | MAPK15 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| CCNE2 | CDKN3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CDK3 | MAPK15 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| CCNE1 | CDKN3 | 0.008 | 0.08 | bioplex_WMM WMM_only |
| CDKN1C | ZNF2 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| CDKN1C | MAPK15 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| CCNE1 | CCND1 | 0.008 | 0.062 | hein_WMM WMM_only |
| CDKN2C | ZNF2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| CDKN1B | MAPK15 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| CDKN1B | ZNF2 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| CDKN1A | MAPK15 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CDKN1A | ZNF2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CDKN2C | CCND2 | 0.008 | 0.045 | bioplex_WMM WMM_only |
| CDK2 | ZNF2 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| CCNE1 | CDK3 | 0.008 | 0.024 | bioplex (CDK3) bioplex_WMM |
| CCND1 | CCNE2 | 0.008 | 0.023 | hein_WMM WMM_only |
| CCNE1 | CCND3 | 0.008 | 0.023 | hein_WMM WMM_only |
| CCND1 | CCND3 | 0.007 | 0.002 | hein_WMM WMM_only |
| CDK2 | CDKN2C | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CDK3 | CDKN1A | 0.003 | 0.011 | bioplex (CDK3) bioplex_WMM |
| CDK2 | CCND1 | 0.003 | 0.011 | hein_WMM bioplex (CCND1) bioplex_WMM hein (CDK2) |
| CDK2 | CCND2 | 0.0 | 0.01 | bioplex (CCND2) bioplex_WMM |
| CDKN1B | CDK3 | 0.0 | 0.01 | bioplex (CDK3) bioplex_WMM |
| CDK3 | CCNE2 | 0.0 | 0.009 | bioplex (CDK3) bioplex_WMM |
| CDK3 | CDKN1C | 0.0 | 0.008 | bioplex (CDK3) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_05212 has an average edge precision of 0.267 which is ranked 5098 out of all 6965 complexes.
Related Complexes