hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05213
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSP90AA1 | Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | UniProt NCBI |
| ABCF1 | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2112 | 2.01342304124e-05 | 0.666666666667 | HSP90AB1 HSP90AA1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 3.35555483123e-05 | 0.666666666667 | HSP90AB1 HSP90AA1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5269 | 5.03310689057e-05 | 0.666666666667 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 8 |
| REAC:R-HSA-5336415 | 6.69449800487e-05 | 0.666666666667 | HSP90AB1 HSP90AA1 | Uptake and function of diphtheria toxin |
| CORUM:5268 | 9.39429153233e-05 | 0.666666666667 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5212 | 9.39429153233e-05 | 0.666666666667 | HSP90AB1 HSP90AA1 | Kinase maturation complex 2 |
| CORUM:5286 | 0.000150966163965 | 0.666666666667 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5266 | 0.000305232445119 | 0.666666666667 | HSP90AB1 HSP90AA1 | TNF-alpha/NF-kappa B signaling complex 6 |
| CORUM:5199 | 0.000402468266231 | 0.666666666667 | HSP90AB1 HSP90AA1 | Kinase maturation complex 1 |
| REAC:R-HSA-3371511 | 0.000441698392473 | 0.666666666667 | HSP90AB1 HSP90AA1 | HSF1 activation |
| REAC:R-HSA-3371568 | 0.000521983812065 | 0.666666666667 | HSP90AB1 HSP90AA1 | Attenuation phase |
| KEGG:04612 | 0.000639364098387 | 0.666666666667 | HSP90AB1 HSP90AA1 | Antigen processing and presentation |
| REAC:R-HSA-9613829 | 0.000702607572674 | 0.666666666667 | HSP90AB1 HSP90AA1 | Chaperone Mediated Autophagy |
| REAC:R-HSA-399954 | 0.000802944115303 | 0.666666666667 | HSP90AB1 HSP90AA1 | Sema3A PAK dependent Axon repulsion |
| KEGG:04657 | 0.00107823602574 | 0.666666666667 | HSP90AB1 HSP90AA1 | IL-17 signaling pathway |
| REAC:R-HSA-5339562 | 0.00140483748394 | 0.666666666667 | HSP90AB1 HSP90AA1 | Uptake and actions of bacterial toxins |
| KEGG:04914 | 0.00144586300556 | 0.666666666667 | HSP90AB1 HSP90AA1 | Progesterone-mediated oocyte maturation |
| KEGG:04659 | 0.00163069203961 | 0.666666666667 | HSP90AB1 HSP90AA1 | Th17 cell differentiation |
| REAC:R-HSA-3371571 | 0.00169234301901 | 0.666666666667 | HSP90AB1 HSP90AA1 | HSF1-dependent transactivation |
| KEGG:05215 | 0.00178652468712 | 0.666666666667 | HSP90AB1 HSP90AA1 | Prostate cancer |
| KEGG:04915 | 0.00328773385609 | 0.666666666667 | HSP90AB1 HSP90AA1 | Estrogen signaling pathway |
| KEGG:05418 | 0.00345163215546 | 0.666666666667 | HSP90AB1 HSP90AA1 | Fluid shear stress and atherosclerosis |
| KEGG:04217 | 0.00510487583083 | 0.666666666667 | HSP90AB1 HSP90AA1 | Necroptosis |
| KEGG:04141 | 0.00544616782939 | 0.666666666667 | HSP90AB1 HSP90AA1 | Protein processing in endoplasmic reticulum |
| KEGG:04621 | 0.00551574183542 | 0.666666666667 | HSP90AB1 HSP90AA1 | NOD-like receptor signaling pathway |
| WP:WP2884 | 0.00582733399611 | 0.666666666667 | HSP90AB1 HSP90AA1 | NRF2 pathway |
| REAC:R-HSA-3371497 | 0.008858224502 | 0.666666666667 | HSP90AB1 HSP90AA1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| REAC:R-HSA-2029482 | 0.011426592715 | 0.666666666667 | HSP90AB1 HSP90AA1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-373755 | 0.011426592715 | 0.666666666667 | HSP90AB1 HSP90AA1 | Semaphorin interactions |
| GO:0030911 | 0.0135228859698 | 0.666666666667 | HSP90AB1 HSP90AA1 | TPR domain binding |
| REAC:R-HSA-8852276 | 0.0190186686906 | 0.666666666667 | HSP90AB1 HSP90AA1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| KEGG:04151 | 0.0198175756043 | 0.666666666667 | HSP90AB1 HSP90AA1 | PI3K-Akt signaling pathway |
| GO:0030235 | 0.020283420769 | 0.666666666667 | HSP90AB1 HSP90AA1 | nitric-oxide synthase regulator activity |
| GO:0044294 | 0.020283420769 | 0.666666666667 | HSP90AB1 HSP90AA1 | dendritic growth cone |
| GO:1902949 | 0.020283420769 | 0.666666666667 | HSP90AB1 HSP90AA1 | positive regulation of tau-protein kinase activity |
| GO:1905323 | 0.020283420769 | 0.666666666667 | HSP90AB1 HSP90AA1 | telomerase holoenzyme complex assembly |
| REAC:R-HSA-2029480 | 0.0210835773835 | 0.666666666667 | HSP90AB1 HSP90AA1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-3371556 | 0.0238137546255 | 0.666666666667 | HSP90AB1 HSP90AA1 | Cellular response to heat stress |
| CORUM:6402 | 0.0249904952816 | 0.333333333333 | HSP90AA1 | NMNAT2-HSP90 complex |
| GO:0044292 | 0.0283955176165 | 0.666666666667 | HSP90AB1 HSP90AA1 | dendrite terminus |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | HSP90AB1 HSP90AA1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP2882 | 0.0314358751755 | 0.666666666667 | HSP90AB1 HSP90AA1 | Nuclear Receptors Meta-Pathway |
| REAC:R-HSA-9612973 | 0.0350118981581 | 0.666666666667 | HSP90AB1 HSP90AA1 | Autophagy |
| WP:WP4172 | 0.0388642175144 | 0.666666666667 | HSP90AB1 HSP90AA1 | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | HSP90AB1 HSP90AA1 | Pathways in cancer |
| GO:1902947 | 0.0486736709081 | 0.666666666667 | HSP90AB1 HSP90AA1 | regulation of tau-protein kinase activity |
| CORUM:4158 | 0.0499776345577 | 0.333333333333 | HSP90AA1 | HSP90-FKBP38-CAM-Ca(2+) complex |
| CORUM:5716 | 0.0499776345577 | 0.333333333333 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
| CORUM:6591 | 0.0499776345577 | 0.333333333333 | HSP90AA1 | Hsp90-p23 complex |
| CORUM:6706 | 0.0499776345577 | 0.333333333333 | HSP90AB1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSP90AA1 | HSP90AB1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (HSP90AA1) Malo fraction boldt_WMM treiber_WMM |
| ABCF1 | HSP90AB1 | 0.043 | 0.268 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| ABCF1 | HSP90AA1 | 0.015 | 0.15 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05213 has an average edge precision of 0.456 which is ranked 2834 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSP90AA1 | HuMAP2_04367 HuMAP2_05213 HuMAP2_06797 |
| HSP90AB1 | HuMAP2_04367 HuMAP2_04784 HuMAP2_05213 HuMAP2_06797 |
| ABCF1 | HuMAP2_02097 HuMAP2_03090 HuMAP2_04156 HuMAP2_05213 |