hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05215
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | UniProt NCBI |
| EEF1AKNMT | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | UniProt NCBI |
| SUMO3 | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) | UniProt NCBI |
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | UniProt NCBI |
| DIS3L2 | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065676 | 0.000134922692372 | 0.4 | SUMO3 SAE1 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 0.000283261545489 | 0.4 | SUMO3 SAE1 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 0.000606744453221 | 0.4 | SUMO3 SAE1 | Processing and activation of SUMO |
| CORUM:5756 | 0.0499494897235 | 0.2 | SAE1 | SUA1-UBA2 complex |
| CORUM:7186 | 0.0499494897235 | 0.2 | GCLC | Glutamate-cysteine ligase |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SAE1 | EEF1AKNMT | 0.179 | 0.438 | bioplex_WMM fraction |
| SAE1 | SUMO3 | 0.056 | 0.313 | hein_WMM bioplex_WMM hein (SUMO3) gupta_WMM fraction |
| SUMO3 | DIS3L2 | 0.036 | 0.263 | fraction |
| GCLC | SAE1 | 0.031 | 0.238 | fraction |
| EEF1AKNMT | SUMO3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05215 has an average edge precision of 0.251 which is ranked 5367 out of all 6965 complexes.
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