hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05221

Confidence: Medium

Genename	Protein Name	Links
LUM	Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican)	UniProt NCBI
SLC9A3R2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)	UniProt NCBI
PTPRJ	Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)	UniProt NCBI
PBK	Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)	UniProt NCBI
DAG1	Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]	UniProt NCBI
LGALS9C	Galectin-9C (Gal-9C) (Galectin-9-like protein B)	UniProt NCBI
LGALS9	Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)	UniProt NCBI
LRRC40	Leucine-rich repeat-containing protein 40	UniProt NCBI
LGALS9B	Galectin-9B (Gal-9B) (Galectin-9-like protein A)	UniProt NCBI
MET	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016936	1.08982291228e-05	0.3	LGALS9C LGALS9 LGALS9B	galactoside binding
GO:2001181	0.000217734118711	0.3	LGALS9C LGALS9 LGALS9B	positive regulation of interleukin-10 secretion
GO:2000562	0.000217734118711	0.3	LGALS9C LGALS9 LGALS9B	negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2001179	0.000380900357231	0.3	LGALS9C LGALS9 LGALS9B	regulation of interleukin-10 secretion
GO:0046642	0.000609225680053	0.3	LGALS9C LGALS9 LGALS9B	negative regulation of alpha-beta T cell proliferation
GO:0035739	0.000913516286731	0.3	LGALS9C LGALS9 LGALS9B	CD4-positive, alpha-beta T cell proliferation
GO:2000561	0.000913516286731	0.3	LGALS9C LGALS9 LGALS9B	regulation of CD4-positive, alpha-beta T cell proliferation
GO:0072608	0.000913516286731	0.3	LGALS9C LGALS9 LGALS9B	interleukin-10 secretion
GO:0032733	0.00737429365883	0.3	LGALS9C LGALS9 LGALS9B	positive regulation of interleukin-10 production
GO:2000515	0.00884603119732	0.3	LGALS9C LGALS9 LGALS9B	negative regulation of CD4-positive, alpha-beta T cell activation
GO:0046633	0.0105009568253	0.3	LGALS9C LGALS9 LGALS9B	alpha-beta T cell proliferation
GO:0046640	0.0105009568253	0.3	LGALS9C LGALS9 LGALS9B	regulation of alpha-beta T cell proliferation
GO:0032689	0.0123497091753	0.3	LGALS9C LGALS9 LGALS9B	negative regulation of interferon-gamma production
REAC:R-HSA-6807004	0.0160241277857	0.2	PTPRJ MET	Negative regulation of MET activity
GO:0046636	0.0166711727856	0.3	LGALS9C LGALS9 LGALS9B	negative regulation of alpha-beta T cell activation
GO:2000778	0.0166711727856	0.3	LGALS9C LGALS9 LGALS9B	positive regulation of interleukin-6 secretion
WP:WP3945	0.0204801297149	0.2	LGALS9C LGALS9B	TYROBP Causal Network
GO:0032653	0.0316085885479	0.3	LGALS9C LGALS9 LGALS9B	regulation of interleukin-10 production
GO:0042130	0.0353891288682	0.3	LGALS9C LGALS9 LGALS9B	negative regulation of T cell proliferation
GO:0032613	0.0438273782088	0.3	LGALS9C LGALS9 LGALS9B	interleukin-10 production
KEGG:04520	0.0446775175102	0.2	PTPRJ MET	Adherens junction
GO:0072604	0.0485060473678	0.3	LGALS9C LGALS9 LGALS9B	interleukin-6 secretion

Edges

Protein 1	Protein 2	Score	Precision	Evidence
LGALS9B	LGALS9	1.0	0.949	bioplex (LGALS9) bioplex_WMM
PBK	LGALS9	0.984	0.899	bioplex (PBK) bioplex_WMM
DAG1	LGALS9	0.92	0.844	bioplex (LGALS9) bioplex_WMM
LGALS9	LGALS9C	0.912	0.835	bioplex (LGALS9C) bioplex_WMM
LGALS9	SLC9A3R2	0.243	0.468	bioplex (LGALS9) bioplex_WMM
LUM	LGALS9	0.116	0.387	bioplex (LGALS9) bioplex_WMM
LGALS9	PTPRJ	0.033	0.246	bioplex (LGALS9) bioplex_WMM
LUM	LRRC40	0.028	0.228	bioplex (LUM) bioplex_WMM boldt boldt_WMM
LGALS9	MET	0.025	0.211	bioplex (LGALS9) bioplex_WMM
DAG1	MET	0.009	0.1	bioplex_WMM WMM_only
LUM	LGALS9B	0.009	0.101	bioplex_WMM WMM_only
DAG1	PTPRJ	0.009	0.095	bioplex_WMM WMM_only
LUM	PTPRJ	0.009	0.098	bioplex_WMM WMM_only
LUM	SLC9A3R2	0.008	0.095	bioplex_WMM WMM_only
LGALS9B	PTPRJ	0.008	0.096	bioplex_WMM WMM_only
LGALS9B	SLC9A3R2	0.008	0.089	bioplex_WMM WMM_only
LUM	MET	0.008	0.089	bioplex_WMM WMM_only
LGALS9B	MET	0.008	0.084	bioplex_WMM WMM_only
PTPRJ	SLC9A3R2	0.008	0.082	bioplex_WMM WMM_only
MET	PTPRJ	0.008	0.065	bioplex_WMM WMM_only
MET	SLC9A3R2	0.008	0.054	bioplex_WMM WMM_only
LUM	DAG1	0.008	0.034	bioplex_WMM WMM_only
DAG1	LGALS9B	0.008	0.022	bioplex_WMM WMM_only
DAG1	SLC9A3R2	0.007	0.011	bioplex_WMM WMM_only
LRRC40	SLC9A3R2	0.007	0.004	bioplex_WMM WMM_only
LRRC40	DAG1	0.007	0.004	gupta_WMM WMM_only
DAG1	LGALS9C	0.005	0.01	bioplex (LGALS9C) bioplex_WMM
PBK	LGALS9B	0.0	0.003	bioplex (PBK) bioplex_WMM

Images

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Complex HuMAP2_05221 has an average edge precision of 0.222 which is ranked 5830 out of all 6965 complexes.

Related Complexes

Genename	Complexes
LUM	HuMAP2_02015 HuMAP2_03100 HuMAP2_05128 HuMAP2_05221
SLC9A3R2	HuMAP2_05221
PTPRJ	HuMAP2_04174 HuMAP2_05221
PBK	HuMAP2_03015 HuMAP2_05221
DAG1	HuMAP2_03015 HuMAP2_05221
LGALS9C	HuMAP2_03015 HuMAP2_05221
LGALS9	HuMAP2_03015 HuMAP2_05221
LRRC40	HuMAP2_02015 HuMAP2_03100 HuMAP2_05128 HuMAP2_05221 HuMAP2_06577
LGALS9B	HuMAP2_03015 HuMAP2_05221
MET	HuMAP2_03390 HuMAP2_04703 HuMAP2_05155 HuMAP2_05221

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05221