hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05224
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APLF | Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | UniProt NCBI |
| WRN | Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2) | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | UniProt NCBI |
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4082 | 1.50819606993e-05 | 0.5 | WRN XRCC6 | XRCC6-XRCC5-WRN complex |
| CORUM:5235 | 3.01612206104e-05 | 0.5 | WRN XRCC6 | WRN-Ku70-Ku80-PARP1 complex |
| REAC:R-HSA-5693532 | 0.000966811034897 | 0.75 | WRN XRCC6 PARP2 | DNA Double-Strand Break Repair |
| MIRNA:hsa-miR-196a-3p | 0.0021509544318 | 0.75 | PARP2 APLF XRCC6 | hsa-miR-196a-3p |
| GO:0006302 | 0.00272272763799 | 1.0 | PARP2 WRN APLF XRCC6 | double-strand break repair |
| REAC:R-HSA-73894 | 0.00725712676591 | 0.75 | WRN XRCC6 PARP2 | DNA Repair |
| GO:0006281 | 0.042993565242 | 1.0 | PARP2 WRN APLF XRCC6 | DNA repair |
| CORUM:328 | 0.0499140284799 | 0.25 | XRCC6 | Ku antigen complex |
| CORUM:1217 | 0.0499140284799 | 0.25 | WRN | WRN-TRF2 complex |
| CORUM:4081 | 0.0499140284799 | 0.25 | XRCC6 | Ku antigen complex |
| CORUM:7282 | 0.0499140284799 | 0.25 | WRN | FEN1-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC6 | WRN | 0.999 | 0.949 | hein_WMM bioplex (XRCC6) bioplex_WMM boldt youn_WMM hein (XRCC6) boldt_WMM |
| APLF | XRCC6 | 0.872 | 0.804 | bioplex (APLF,XRCC6) bioplex_WMM |
| PARP2 | APLF | 0.543 | 0.644 | bioplex (APLF) bioplex_WMM |
| PARP2 | XRCC6 | 0.088 | 0.352 | bioplex (XRCC6) bioplex_WMM boldt_WMM |
| APLF | WRN | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PARP2 | WRN | 0.008 | 0.044 | bioplex_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_05224 has an average edge precision of 0.48 which is ranked 2639 out of all 6965 complexes.
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