hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05240
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| H2BC13 | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | UniProt NCBI |
| H2BC1 | Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B) | UniProt NCBI |
| BAHD1 | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | UniProt NCBI |
| MIER1 | Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) | UniProt NCBI |
| SRCAP | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0006325 | 0.00448062284804 | 1.0 | SRCAP BAHD1 H2BC13 H2BC1 MIER1 | chromatin organization |
| REAC:R-HSA-171306 | 0.0170965985867 | 0.4 | H2BC13 H2BC1 | Packaging Of Telomere Ends |
| REAC:R-HSA-110331 | 0.019180674733 | 0.4 | H2BC13 H2BC1 | Cleavage of the damaged purine |
| REAC:R-HSA-73927 | 0.019180674733 | 0.4 | H2BC13 H2BC1 | Depurination |
| REAC:R-HSA-110330 | 0.019180674733 | 0.4 | H2BC13 H2BC1 | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-8866654 | 0.0206361227401 | 0.4 | H2BC13 H2BC1 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-73928 | 0.0221443716613 | 0.4 | H2BC13 H2BC1 | Depyrimidination |
| REAC:R-HSA-110328 | 0.0221443716613 | 0.4 | H2BC13 H2BC1 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-110329 | 0.0221443716613 | 0.4 | H2BC13 H2BC1 | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-73929 | 0.0229182830201 | 0.4 | H2BC13 H2BC1 | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-73728 | 0.0253191001807 | 0.4 | H2BC13 H2BC1 | RNA Polymerase I Promoter Opening |
| KEGG:05322 | 0.0267668372004 | 0.4 | H2BC13 H2BC1 | Systemic lupus erythematosus |
| REAC:R-HSA-5334118 | 0.0269854937899 | 0.4 | H2BC13 H2BC1 | DNA methylation |
| REAC:R-HSA-5625886 | 0.0287045163353 | 0.4 | H2BC13 H2BC1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| REAC:R-HSA-427359 | 0.0295837500362 | 0.4 | H2BC13 H2BC1 | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-5693571 | 0.0313816354582 | 0.4 | H2BC13 H2BC1 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-606279 | 0.0341769281663 | 0.4 | H2BC13 H2BC1 | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-2299718 | 0.0341769281663 | 0.4 | H2BC13 H2BC1 | Condensation of Prophase Chromosomes |
| REAC:R-HSA-212300 | 0.0341769281663 | 0.4 | H2BC13 H2BC1 | PRC2 methylates histones and DNA |
| REAC:R-HSA-774815 | 0.0341769281663 | 0.4 | H2BC13 H2BC1 | Nucleosome assembly |
| REAC:R-HSA-8852135 | 0.0370902496619 | 0.4 | H2BC13 H2BC1 | Protein ubiquitination |
| REAC:R-HSA-427389 | 0.0370902496619 | 0.4 | H2BC13 H2BC1 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| REAC:R-HSA-1221632 | 0.0370902496619 | 0.4 | H2BC13 H2BC1 | Meiotic synapsis |
| REAC:R-HSA-5693565 | 0.0380875604325 | 0.4 | H2BC13 H2BC1 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0390979640759 | 0.4 | H2BC13 H2BC1 | DNA Double Strand Break Response |
| REAC:R-HSA-2559586 | 0.0411580285567 | 0.4 | H2BC13 H2BC1 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-157579 | 0.0432704002666 | 0.4 | H2BC13 H2BC1 | Telomere Maintenance |
| REAC:R-HSA-9616222 | 0.0454350363854 | 0.4 | H2BC13 H2BC1 | Transcriptional regulation of granulopoiesis |
| GO:0051276 | 0.046479053704 | 1.0 | SRCAP BAHD1 H2BC13 H2BC1 MIER1 | chromosome organization |
| REAC:R-HSA-912446 | 0.0476518941102 | 0.4 | H2BC13 H2BC1 | Meiotic recombination |
| MIRNA:hsa-miR-4507 | 0.0482780268961 | 0.4 | H2BC13 H2BC1 | hsa-miR-4507 |
| MIRNA:hsa-miR-6839-3p | 0.0482780268961 | 0.4 | H2BC13 H2BC1 | hsa-miR-6839-3p |
| REAC:R-HSA-73884 | 0.0499209306556 | 0.4 | H2BC13 H2BC1 | Base Excision Repair |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MIER1 | H2BC1 | 0.999 | 0.949 | bioplex (H2BC1) bioplex_WMM |
| H2BC1 | BAHD1 | 0.998 | 0.942 | bioplex (H2BC1) bioplex_WMM |
| H2BC1 | H2BC13 | 0.94 | 0.852 | bioplex (H2BC1) bioplex_WMM |
| H2BC1 | SRCAP | 0.514 | 0.632 | bioplex (H2BC1) bioplex_WMM |
| MIER1 | BAHD1 | 0.01 | 0.121 | bioplex_WMM WMM_only |
| BAHD1 | H2BC13 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| BAHD1 | SRCAP | 0.008 | 0.067 | bioplex_WMM WMM_only |
| MIER1 | H2BC13 | 0.008 | 0.014 | bioplex_WMM WMM_only |
| MIER1 | SRCAP | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| H2BC13 | SRCAP | 0.007 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05240 has an average edge precision of 0.368 which is ranked 3669 out of all 6965 complexes.
Related Complexes