hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05246
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERLIN1 | Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1) | UniProt NCBI |
| ERLIN2 | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | UniProt NCBI |
| DUSP3 | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | UniProt NCBI |
| RNF170 | E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6476 | 6.75231048499e-10 | 0.75 | ERLIN1 ERLIN2 RNF170 | erlin1/2-RNF170 complex |
| HP:0003487 | 0.00367883182322 | 0.75 | ERLIN1 ERLIN2 RNF170 | Babinski sign |
| HP:0031828 | 0.00367883182322 | 0.75 | ERLIN1 ERLIN2 RNF170 | Abnormal superficial reflex |
| HP:0007256 | 0.0133967549828 | 0.75 | ERLIN1 ERLIN2 RNF170 | Abnormal pyramidal sign |
| REAC:R-HSA-5678895 | 0.0177060142151 | 0.5 | ERLIN1 ERLIN2 | Defective CFTR causes cystic fibrosis |
| GO:0045541 | 0.0270421395626 | 0.5 | ERLIN1 ERLIN2 | negative regulation of cholesterol biosynthetic process |
| GO:0090206 | 0.0270421395626 | 0.5 | ERLIN1 ERLIN2 | negative regulation of cholesterol metabolic process |
| GO:0106119 | 0.0270421395626 | 0.5 | ERLIN1 ERLIN2 | negative regulation of sterol biosynthetic process |
| REAC:R-HSA-5619084 | 0.0284687652941 | 0.5 | ERLIN1 ERLIN2 | ABC transporter disorders |
| HP:0002064 | 0.0335949626331 | 0.5 | ERLIN1 ERLIN2 | Spastic gait |
| HP:0006380 | 0.0335949626331 | 0.5 | ERLIN1 ERLIN2 | Knee flexion contracture |
| REAC:R-HSA-382556 | 0.0483568152087 | 0.5 | ERLIN1 ERLIN2 | ABC-family proteins mediated transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERLIN1 | ERLIN2 | 0.53 | 0.635 | hein_WMM bioplex (ERLIN1,ERLIN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RNF170 | ERLIN1 | 0.061 | 0.339 | bioplex (RNF170) bioplex_WMM |
| RNF170 | ERLIN2 | 0.035 | 0.261 | bioplex (RNF170) bioplex_WMM |
| ERLIN1 | DUSP3 | 0.034 | 0.258 | bioplex (ERLIN1) bioplex_WMM |
| ERLIN2 | DUSP3 | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05246 has an average edge precision of 0.299 which is ranked 4607 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ERLIN1 | HuMAP2_00297 HuMAP2_00520 HuMAP2_04947 HuMAP2_05246 |
| ERLIN2 | HuMAP2_00297 HuMAP2_00520 HuMAP2_04947 HuMAP2_05246 HuMAP2_05982 |
| DUSP3 | HuMAP2_04947 HuMAP2_05246 |
| RNF170 | HuMAP2_00297 HuMAP2_04947 HuMAP2_05246 |